Acne

Metadata

Name	Acne (acne)
Category	Skin
Sex
Adult	Yes
UUID	75a07fdf-d99b-44e6-8f67-94f0d1e73bd2
Definition	Acne is a common skin condition that causes spots and oily skin.

Ontologies

Disease Ontology (DOID)	DOID_6543
GWAS Catalogue	EFO_0003894
MeSH	D000152
SNOMED-CT	11381005
FinnGen	L12_ACNE

Key Summary Statistics

Cases from any source

Total	6076
Female (%)	3929 (65%)
Male (%)	2147 (35%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	270.41 (259.5,281.33)
Male	177.79 (168.1,187.48)

Incidence stratified by sex

Female	2.87 (2.43,3.32)
Male	1.91 (1.51,2.3)

Incidence stratified by age

Ages 40-44	6.91 (5.23,8.59)
Ages 45-49	4.79 (3.6,5.98)
Ages 50-54	2.41 (1.64,3.19)
Ages 55-59	1.27 (0.76,1.78)
Ages 60-64	1.28 (0.85,1.72)
Ages 65-69	1.37 (0.85,1.88)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	488 (467,509)	252 (240,264)	125 (117,132)
CALIBER	633 (626,639)	332 (326,337)	153 (149,157)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	545(493,600)	278(250,307)	121(106,138)
Low	503(453,558)	265(237,294)	125(110,142)
Medium	487(439,538)	253(227,282)	121(106,138)
High	478(435,525)	234(209,261)	131(114,149)
Most deprived	450(410,492)	231(206,258)	125(108,144)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	485(462,509)	248(235,262)	124(116,132)
Scotland	522(461,589)	294(260,332)	137(116,161)
Wales	464(392,547)	219(181,262)	116(92,144)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153513, Events=116

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.85 (1.14, 2.99)	0.0128
BMI	obese	1.9 (1.12, 3.22)	0.0174
BMI	underweight	0 (0, Inf)	0.993
smoking	previous	0.82 (0.53, 1.27)	0.367
smoking	current	1.79 (1.09, 2.95)	0.0215
hypertension	yes	1.55 (1.01, 2.37)	0.0432

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1548	acne/acne vulgaris
41202	Diagnoses - main ICD10	L70.0	Acne vulgaris
41202	Diagnoses - main ICD10	L70.1	Acne conglobata
41202	Diagnoses - main ICD10	L70.2	Acne varioliformis
41202	Diagnoses - main ICD10	L70.3	Acne tropica
41202	Diagnoses - main ICD10	L70.8	Other acne
41202	Diagnoses - main ICD10	L70.9	Acne, unspecified
41204	Diagnoses - secondary ICD10	L70.0	Acne vulgaris
41204	Diagnoses - secondary ICD10	L70.1	Acne conglobata
41204	Diagnoses - secondary ICD10	L70.2	Acne varioliformis
41204	Diagnoses - secondary ICD10	L70.3	Acne tropica
41204	Diagnoses - secondary ICD10	L70.8	Other acne
41204	Diagnoses - secondary ICD10	L70.9	Acne, unspecified
40001	Underlying (primary) cause of death: ICD10	L70.0	Acne vulgaris
40001	Underlying (primary) cause of death: ICD10	L70.1	Acne conglobata
40001	Underlying (primary) cause of death: ICD10	L70.2	Acne varioliformis
40001	Underlying (primary) cause of death: ICD10	L70.3	Acne tropica
40001	Underlying (primary) cause of death: ICD10	L70.8	Other acne
40001	Underlying (primary) cause of death: ICD10	L70.9	Acne, unspecified
40002	Contributory (secondary) causes of death: ICD10	L70.0	Acne vulgaris
40002	Contributory (secondary) causes of death: ICD10	L70.1	Acne conglobata
40002	Contributory (secondary) causes of death: ICD10	L70.2	Acne varioliformis
40002	Contributory (secondary) causes of death: ICD10	L70.3	Acne tropica
40002	Contributory (secondary) causes of death: ICD10	L70.8	Other acne
40002	Contributory (secondary) causes of death: ICD10	L70.9	Acne, unspecified
42040	GP clinical event records	2FG5.00	Acne scar
42040	GP clinical event records	M260000	Acne frontalis
42040	GP clinical event records	M260.00	Acne varioliformis
42040	GP clinical event records	M260z00	Acne varioliformis NOS
42040	GP clinical event records	M260z11	Acne necrotica
42040	GP clinical event records	M261000	Acne vulgaris
42040	GP clinical event records	M261011	Blackhead
42040	GP clinical event records	M261012	Comedo
42040	GP clinical event records	M261100	Acne conglobata
42040	GP clinical event records	M261200	Bromine acne
42040	GP clinical event records	M261300	Chlorine acne
42040	GP clinical event records	M261400	Iodine acne
42040	GP clinical event records	M261500	Colloid acne
42040	GP clinical event records	M261600	Cystic acne
42040	GP clinical event records	M261900	Occupational acne
42040	GP clinical event records	M261A00	Pustular acne
42040	GP clinical event records	M261B00	Steroid acne
42040	GP clinical event records	M261C00	Tropical acne
42040	GP clinical event records	M261F00	Acne fulminans
42040	GP clinical event records	M261G00	Acne agminata
42040	GP clinical event records	M261J00	Acne necrotica
42040	GP clinical event records	M261.00	Other acne
42040	GP clinical event records	M261X00	Acne, unspecified
42040	GP clinical event records	M261z00	Other acne NOS
42040	GP clinical event records	M26y200	Giant comedo
42040	GP clinical event records	Myu6800	[X]Other acne
42040	GP clinical event records	Myu6F00	[X]Acne, unspecified
42040	GP clinical event records	N25..00	SAPHO syndrome Synov, Acne, Pustul, Hyperost, Osteomyelitis
42040	GP clinical event records	X75uJ	Acne scar
42040	GP clinical event records	X50Es	Acne necrotica
42040	GP clinical event records	XE1BN	Acne varioliformis NOS
42040	GP clinical event records	XE1BO	Acne vulgaris
42040	GP clinical event records	X50A8	Acne fulminans
42040	GP clinical event records	X50AF	Giant comedo
42040	GP clinical event records	X50AL	Acne agminata