| Name |
Actinic keratosis (actinic_keratosis) |
| Category |
Skin |
| Sex |
|
| Adult |
Yes |
| UUID |
aa9a574f-39cb-44f0-bea8-dd0a92d8a577 |
| Definition |
Actinic keratosis (AK) is the most common precancer that forms on skin damaged by chronic exposure to ultraviolet (UV) rays from the sun and/or indoor tanning. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
16197 |
| Female (%) |
7041 (43%) |
| Male (%) |
9156 (57%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
156.07 (147.73,164.41) |
| Male |
238.13 (226.95,249.31) |
Incidence stratified by sex
| Female |
32.9 (31.39,34.41) |
| Male |
60.76 (58.5,63.03) |
Incidence stratified by age
| Ages 40-44 |
10.4 (8.39,12.41) |
| Ages 45-49 |
17.44 (15.2,19.68) |
| Ages 50-54 |
26.15 (23.61,28.69) |
| Ages 55-59 |
39.73 (36.87,42.58) |
| Ages 60-64 |
62.67 (59.56,65.78) |
| Ages 65-69 |
83.03 (78.89,87.16) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
101 (92,112) |
296 (283,310) |
696 (679,714) |
| CALIBER |
56 (54,58) |
64 (61,66) |
75 (72,77) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
139(113,169) |
347(316,382) |
803(763,844) |
| Low |
116(92,145) |
358(325,392) |
764(725,804) |
| Medium |
108(86,134) |
317(287,350) |
730(691,770) |
| High |
92(73,115) |
287(259,318) |
635(597,674) |
| Most deprived |
69(54,87) |
178(156,202) |
508(473,545) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
104(93,115) |
311(295,326) |
717(697,737) |
| Scotland |
73(51,101) |
154(128,182) |
313(280,349) |
| Wales |
126(89,174) |
396(343,454) |
1068(992,1148) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153513, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.85 (1.14, 2.99) |
0.0128 |
| BMI |
obese |
1.9 (1.12, 3.22) |
0.0174 |
| BMI |
underweight |
0 (0, Inf) |
0.993 |
| smoking |
previous |
0.82 (0.53, 1.27) |
0.367 |
| smoking |
current |
1.79 (1.09, 2.95) |
0.0215 |
| hypertension |
yes |
1.55 (1.01, 2.37) |
0.0432 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
L57.0 |
Actinic keratosis |
| 41204 |
Diagnoses - secondary ICD10 |
L57.0 |
Actinic keratosis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L57.0 |
Actinic keratosis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L57.0 |
Actinic keratosis |
| 42040 |
GP clinical event records |
7G09800 |
Cryotherapy to actinic keratosis |
| 42040 |
GP clinical event records |
M222.00 |
Senile keratoma |
| 42040 |
GP clinical event records |
M226.00 |
Solar keratosis |
| 42040 |
GP clinical event records |
M226.11 |
Actinic keratosis |
| 42040 |
GP clinical event records |
XaREo |
Cryotherapy to actinic keratosis |