Hyperkinetic disorders

Metadata

Name	Hyperkinetic disorders (ADHD)
Category	Psychiatric
Sex
Adult	Yes
UUID	f28bc923-da20-4b75-a744-327afcb29cc7
Definition	A mental disorder characterized by inattention, easy distraction, careless mistakes and avoidance of tasks that require sustained mental focus. These behaviors can lead to maladaptive consequences in the affected individual’s life.

Ontologies

Disease Ontology (DOID)	DOID_1094
GWAS Catalogue	EFO_0003888
MeSH	D001289
SNOMED-CT	406506008
FinnGen	KRA_PSY_HYPERKIN

Key Summary Statistics

Cases from any source

Total	58
Female (%)	25 (43%)
Male (%)	33 (57%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	0.59 (0.07,1.11)
Male	0.56 (0.01,1.11)

Incidence stratified by sex

Female	0.07 (0.0,0.14)
Male	0.08 (0.0,0.17)

Incidence stratified by age

Ages 40-44	0.3 (-0.04,0.64)
Ages 45-49	0.15 (-0.06,0.35)
Ages 50-54	0.0 (0.0,0.0)
Ages 55-59	0.05 (-0.05,0.15)
Ages 60-64	0.08 (-0.03,0.18)
Ages 65-69	0.0 (0.0,0.0)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	2 (1,4)	1 (0,2)	1 (0,2)
CALIBER	5 (5,6)	3 (3,4)	–

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	3(0,10)	0(NaN,NaN)	1(0,4)
Low	0(NaN,NaN)	2(0,7)	1(0,3)
Medium	0(NaN,NaN)	1(0,5)	1(0,4)
High	5(1,12)	1(0,4)	1(0,3)
Most deprived	1(0,5)	0(NaN,NaN)	1(0,4)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	2(1,4)	1(0,1)	1(0,2)
Scotland	5(1,17)	1(0,7)	1(0,5)
Wales	0(NaN,NaN)	2(0,12)	2(0,9)

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	F90	Hyperkinetic disorders
41204	Diagnoses - secondary ICD10	F90	Hyperkinetic disorders
40001	Underlying (primary) cause of death: ICD10	F90	Hyperkinetic disorders
40002	Contributory (secondary) causes of death: ICD10	F90	Hyperkinetic disorders
42040	GP clinical event records	6A61.00	Attention deficit hyperactivity disorder annual review
42040	GP clinical event records	8BPT.00	Drug therapy ADHD (attention deficit hyperactivity disorder)
42040	GP clinical event records	9Ngp.00	On drug ther ADHD (attention deficit hyperactivity disorder)
42040	GP clinical event records	E2E0100	Attention deficit with hyperactivity
42040	GP clinical event records	E2E1.00	Hyperkinesis with developmental delay
42040	GP clinical event records	E2E2.00	Hyperkinetic conduct disorder
42040	GP clinical event records	E2E..00	Childhood hyperkinetic syndrome
42040	GP clinical event records	E2E..11	Overactive child syndrome
42040	GP clinical event records	E2Ey.00	Other hyperkinetic manifestation
42040	GP clinical event records	E2Ez.00	Hyperkinetic syndrome NOS
42040	GP clinical event records	Eu84400	[X]Overactive disorder assoc mental retard/stereotype movts
42040	GP clinical event records	Eu90000	[X]Disturbance of activity and attention
42040	GP clinical event records	Eu90011	[X]Attention deficit hyperactivity disorder
42040	GP clinical event records	Eu90100	[X]Hyperkinetic conduct disorder
42040	GP clinical event records	Eu90111	[X]Hyperkinetic disorder associated with conduct disorder
42040	GP clinical event records	Eu90.00	[X]Hyperkinetic disorders
42040	GP clinical event records	Eu90y00	[X]Other hyperkinetic disorders
42040	GP clinical event records	Eu90z00	[X]Hyperkinetic disorder, unspecified
42040	GP clinical event records	Eu90z11	[X]Hyperkinetic reaction of childhood or adolescence NOS
42040	GP clinical event records	Eu90z12	[X]Hyperkinetic syndrome NOS
42040	GP clinical event records	XaVw9	Attention deficit hyperactivity disorder annual review
42040	GP clinical event records	XaaZA	Drug therapy for ADHD (attention deficit hyperactivity disorder)
42040	GP clinical event records	Xaae7	On drug therapy for ADHD (attention deficit hyperactivity disorder)