| Name |
Agranulocytosis (agranulocytosis) |
| Category |
Haematological or immunological |
| Sex |
|
| Adult |
Yes |
| UUID |
68bfae22-ef38-4abc-bfe9-91b44d596855 |
| Definition |
Agranulocytosis is a condition in which the absolute neutrophil count (ANC) is less than 100 neutrophils per microlitre of blood. People with this condition are at a very high risk of severe infection. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
8320 |
| Female (%) |
4972 (60%) |
| Male (%) |
3348 (40%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
77.68 (71.77,83.59) |
| Male |
38.78 (34.22,43.34) |
Incidence stratified by sex
| Female |
13.29 (12.33,14.24) |
| Male |
10.18 (9.27,11.09) |
Incidence stratified by age
| Ages 40-44 |
6.57 (4.97,8.17) |
| Ages 45-49 |
7.99 (6.48,9.51) |
| Ages 50-54 |
11.17 (9.51,12.82) |
| Ages 55-59 |
13.48 (11.83,15.12) |
| Ages 60-64 |
13.91 (12.47,15.35) |
| Ages 65-69 |
13.48 (11.86,15.1) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
84 (75,93) |
121 (113,130) |
149 (141,157) |
| CALIBER |
51 (49,53) |
85 (82,87) |
120 (116,123) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
80(61,104) |
122(104,142) |
156(140,175) |
| Low |
72(54,94) |
117(99,137) |
142(126,160) |
| Medium |
77(59,99) |
110(93,130) |
149(132,168) |
| High |
106(86,129) |
115(98,134) |
148(130,167) |
| Most deprived |
80(64,99) |
143(124,164) |
151(132,171) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
81(71,91) |
124(115,134) |
148(139,157) |
| Scotland |
97(72,128) |
98(79,120) |
143(121,166) |
| Wales |
96(65,137) |
134(105,168) |
169(140,203) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153321, Events=259
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.47 (1.07, 2.01) |
0.0165 |
| BMI |
obese |
2.46 (1.81, 3.35) |
1.19e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.998 |
| smoking |
previous |
1.06 (0.81, 1.39) |
0.676 |
| smoking |
current |
0.75 (0.46, 1.22) |
0.25 |
| hypertension |
yes |
0.83 (0.58, 1.19) |
0.31 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1448 |
neutropenia/lymphopenia |
| 41202 |
Diagnoses - main ICD10 |
D70 |
Agranulocytosis |
| 41204 |
Diagnoses - secondary ICD10 |
D70 |
Agranulocytosis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D70 |
Agranulocytosis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D70 |
Agranulocytosis |
| 42040 |
GP clinical event records |
42H2.00 |
Leucopenia - low white count |
| 42040 |
GP clinical event records |
42H2.11 |
Leucopenia |
| 42040 |
GP clinical event records |
42H4.00 |
Agranulocytosis |
| 42040 |
GP clinical event records |
42J2.00 |
Neutropenia |
| 42040 |
GP clinical event records |
D400000 |
Idiopathic agranulocytosis |
| 42040 |
GP clinical event records |
D400011 |
Idiopathic neutropenia |
| 42040 |
GP clinical event records |
D400100 |
Primary splenic neutropenia |
| 42040 |
GP clinical event records |
D400200 |
Agranulocytosis - drug induced |
| 42040 |
GP clinical event records |
D400211 |
Neutropenia - drug induced |
| 42040 |
GP clinical event records |
D400312 |
Neutropenia due to irradiation |
| 42040 |
GP clinical event records |
D400400 |
Agranulocytosis due to infection |
| 42040 |
GP clinical event records |
D400411 |
Neutropenia due to infection |
| 42040 |
GP clinical event records |
D400600 |
Drug-induced neutropenia |
| 42040 |
GP clinical event records |
D400800 |
Acquired neutropenia NEC |
| 42040 |
GP clinical event records |
D400811 |
Acquired agranulocytosis NEC |
| 42040 |
GP clinical event records |
D400900 |
Cyclical neutropenia |
| 42040 |
GP clinical event records |
D400A00 |
Leucopenia |
| 42040 |
GP clinical event records |
D400.00 |
Agranulocytosis |
| 42040 |
GP clinical event records |
D400.11 |
Kostmann’s syndrome |
| 42040 |
GP clinical event records |
D400.12 |
Neutropenia |
| 42040 |
GP clinical event records |
D400y00 |
Other specified agranulocytosis |
| 42040 |
GP clinical event records |
D400z00 |
Agranulocytosis NOS |
| 42040 |
GP clinical event records |
42H4. |
Agranulocytosis |
| 42040 |
GP clinical event records |
42H2. |
Leucopenia |
| 42040 |
GP clinical event records |
XE14G |
Acquired neutropenia NEC |