| Name |
Acute Kidney Injury (AKI) |
| Category |
Genitourinary |
| Sex |
|
| Adult |
Yes |
| UUID |
36f7c398-f3e6-4d8f-a159-76d85f826ebe |
| Definition |
An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
20544 |
| Female (%) |
8011 (39%) |
| Male (%) |
12533 (61%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
9.08 (7.05,11.1) |
| Male |
22.68 (19.19,26.17) |
Incidence stratified by sex
| Female |
11.13 (10.26,12.0) |
| Male |
24.08 (22.68,25.48) |
Incidence stratified by age
| Ages 40-44 |
3.42 (2.27,4.57) |
| Ages 45-49 |
6.02 (4.71,7.33) |
| Ages 50-54 |
9.26 (7.76,10.77) |
| Ages 55-59 |
13.24 (11.61,14.86) |
| Ages 60-64 |
21.68 (19.89,23.47) |
| Ages 65-69 |
35.04 (32.43,37.65) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
33 (27,39) |
72 (65,79) |
157 (149,165) |
| CALIBER |
46 (44,48) |
103 (100,106) |
249 (244,254) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
20(11,33) |
47(36,61) |
110(96,126) |
| Low |
29(18,45) |
50(38,64) |
127(111,144) |
| Medium |
26(16,41) |
56(44,71) |
131(115,149) |
| High |
31(20,45) |
76(61,92) |
173(153,194) |
| Most deprived |
50(37,65) |
126(108,147) |
266(241,293) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
35(28,42) |
73(65,81) |
158(149,167) |
| Scotland |
28(15,47) |
71(54,92) |
150(127,175) |
| Wales |
21(8,45) |
64(44,91) |
154(126,187) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
N17.0 |
Acute renal failure with tubular necrosis |
| 41202 |
Diagnoses - main ICD10 |
N17.1 |
Acute renal failure with acute cortical necrosis |
| 41202 |
Diagnoses - main ICD10 |
N17.2 |
Acute renal failure with medullary necrosis |
| 41202 |
Diagnoses - main ICD10 |
N17.8 |
Other acute renal failure |
| 41202 |
Diagnoses - main ICD10 |
N17.9 |
Acute renal failure, unspecified |
| 41204 |
Diagnoses - secondary ICD10 |
N17.0 |
Acute renal failure with tubular necrosis |
| 41204 |
Diagnoses - secondary ICD10 |
N17.1 |
Acute renal failure with acute cortical necrosis |
| 41204 |
Diagnoses - secondary ICD10 |
N17.2 |
Acute renal failure with medullary necrosis |
| 41204 |
Diagnoses - secondary ICD10 |
N17.8 |
Other acute renal failure |
| 41204 |
Diagnoses - secondary ICD10 |
N17.9 |
Acute renal failure, unspecified |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N17.0 |
Acute renal failure with tubular necrosis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N17.1 |
Acute renal failure with acute cortical necrosis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N17.2 |
Acute renal failure with medullary necrosis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N17.8 |
Other acute renal failure |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N17.9 |
Acute renal failure, unspecified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N17.0 |
Acute renal failure with tubular necrosis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N17.1 |
Acute renal failure with acute cortical necrosis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N17.2 |
Acute renal failure with medullary necrosis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N17.8 |
Other acute renal failure |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N17.9 |
Acute renal failure, unspecified |