Metadata

Name Alcohol Problems (alc_problems)
Category Psychiatric
Sex
Adult Yes
UUID 4c136293-9a6d-4106-b7d4-b9aa67b1fe38
Definition Regular consumption of alcohol above recommended levels

Ontologies

Disease Ontology (DOID) DOID_0050741
GWAS Catalogue MONDO_0007079
MeSH D019973
SNOMED-CT 7200002
FinnGen F5_ALCOHOL_DEPENDENCE

Key Summary Statistics

Cases from any source

Total 18528
Female (%) 5994 (32%)
Male (%) 12534 (68%)

Year first recorded

alc_problems year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced alc_problems cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of alc_problems

Baseline prevalence stratified by sex

Female 67.43 (61.92,72.93)
Male 223.01 (212.18,233.84)

Incidence stratified by sex

Female 39.02 (37.38,40.66)
Male 79.91 (77.32,82.51)

Incidence stratified by age

Ages 40-44 50.41 (45.95,54.87)
Ages 45-49 56.66 (52.59,60.73)
Ages 50-54 59.99 (56.11,63.87)
Ages 55-59 58.99 (55.51,62.48)
Ages 60-64 58.29 (55.32,61.27)
Ages 65-69 56.38 (53.04,59.73)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB alc_problems prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 414 (394,434) 489 (472,507) 453 (439,467)
CALIBER 436 (431,441) 467 (461,474) 434 (428,441)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 365(322,412) 347(315,381) 359(333,387)
Low 338(296,385) 367(334,403) 351(325,379)
Medium 324(284,368) 431(395,469) 416(386,446)
High 391(350,435) 517(478,558) 478(445,513)
Most deprived 581(536,630) 762(715,811) 707(665,750)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 421(399,444) 474(455,493) 437(422,453)
Scotland 511(449,580) 737(680,798) 731(679,786)
Wales 173(128,228) 220(181,266) 195(163,232)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=152960, Events=163

Factor Level Hazard Ratio P value
BMI overweight 1.3 (0.88, 1.92) 0.185
BMI obese 1.75 (1.16, 2.63) 0.00738
BMI underweight 0 (0, Inf) 0.991
smoking previous 1.02 (0.7, 1.49) 0.904
smoking current 3.45 (2.37, 5.02) 8.66e-11
hypertension yes 1.36 (0.94, 1.95) 0.101

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1408 alcohol dependency
20002 Non-cancer illness code, self-reported 1604 alcoholic liver disease / alcoholic cirrhosis
41202 Diagnoses - main ICD10 F10.1 Mental and behavioural disorders due to use of alcohol - Harmful use
41202 Diagnoses - main ICD10 F10.2 Mental and behavioural disorders due to use of alcohol - Dependence syndrome
41202 Diagnoses - main ICD10 F10.3 Mental and behavioural disorders due to use of alcohol - Withdrawal state
41202 Diagnoses - main ICD10 F10.4 Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium
41202 Diagnoses - main ICD10 F10.5 Mental and behavioural disorders due to use of alcohol - Psychotic disorder
41202 Diagnoses - main ICD10 F10.6 Mental and behavioural disorders due to use of alcohol - Amnesic syndrome
41202 Diagnoses - main ICD10 F10.7 Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder
41202 Diagnoses - main ICD10 F10.8 Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders
41202 Diagnoses - main ICD10 F10.9 Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder
41202 Diagnoses - main ICD10 E24.4 Alcohol-induced pseudo-Cushing’s syndrome
41202 Diagnoses - main ICD10 G31.2 Degeneration of nervous system due to alcohol
41202 Diagnoses - main ICD10 G62.1 Alcoholic polyneuropathy
41202 Diagnoses - main ICD10 G72.1 Alcoholic myopathy
41202 Diagnoses - main ICD10 I42.6 Alcoholic cardiomyopathy
41202 Diagnoses - main ICD10 K29.2 Alcoholic gastritis
41202 Diagnoses - main ICD10 K70 Alcoholic liver disease
41202 Diagnoses - main ICD10 K85.2 Alcohol-induced acute pancreatitis
41202 Diagnoses - main ICD10 K86.0 Alcohol-induced chronic pancreatitis
41202 Diagnoses - main ICD10 Z50.2 Alcohol rehabilitation
41202 Diagnoses - main ICD10 Z71.4 Alcohol abuse counselling and surveillance
41204 Diagnoses - secondary ICD10 F10.1 Mental and behavioural disorders due to use of alcohol - Harmful use
41204 Diagnoses - secondary ICD10 F10.2 Mental and behavioural disorders due to use of alcohol - Dependence syndrome
41204 Diagnoses - secondary ICD10 F10.3 Mental and behavioural disorders due to use of alcohol - Withdrawal state
41204 Diagnoses - secondary ICD10 F10.4 Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium
41204 Diagnoses - secondary ICD10 F10.5 Mental and behavioural disorders due to use of alcohol - Psychotic disorder
41204 Diagnoses - secondary ICD10 F10.6 Mental and behavioural disorders due to use of alcohol - Amnesic syndrome
41204 Diagnoses - secondary ICD10 F10.7 Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder
41204 Diagnoses - secondary ICD10 F10.8 Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders
41204 Diagnoses - secondary ICD10 F10.9 Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder
41204 Diagnoses - secondary ICD10 E24.4 Alcohol-induced pseudo-Cushing’s syndrome
41204 Diagnoses - secondary ICD10 G31.2 Degeneration of nervous system due to alcohol
41204 Diagnoses - secondary ICD10 G62.1 Alcoholic polyneuropathy
41204 Diagnoses - secondary ICD10 G72.1 Alcoholic myopathy
41204 Diagnoses - secondary ICD10 I42.6 Alcoholic cardiomyopathy
41204 Diagnoses - secondary ICD10 K29.2 Alcoholic gastritis
41204 Diagnoses - secondary ICD10 K70 Alcoholic liver disease
41204 Diagnoses - secondary ICD10 K85.2 Alcohol-induced acute pancreatitis
41204 Diagnoses - secondary ICD10 K86.0 Alcohol-induced chronic pancreatitis
41204 Diagnoses - secondary ICD10 Z50.2 Alcohol rehabilitation
41204 Diagnoses - secondary ICD10 Z71.4 Alcohol abuse counselling and surveillance
40001 Underlying (primary) cause of death: ICD10 F10.1 Mental and behavioural disorders due to use of alcohol - Harmful use
40001 Underlying (primary) cause of death: ICD10 F10.2 Mental and behavioural disorders due to use of alcohol - Dependence syndrome
40001 Underlying (primary) cause of death: ICD10 F10.3 Mental and behavioural disorders due to use of alcohol - Withdrawal state
40001 Underlying (primary) cause of death: ICD10 F10.4 Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium
40001 Underlying (primary) cause of death: ICD10 F10.5 Mental and behavioural disorders due to use of alcohol - Psychotic disorder
40001 Underlying (primary) cause of death: ICD10 F10.6 Mental and behavioural disorders due to use of alcohol - Amnesic syndrome
40001 Underlying (primary) cause of death: ICD10 F10.7 Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder
40001 Underlying (primary) cause of death: ICD10 F10.8 Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders
40001 Underlying (primary) cause of death: ICD10 F10.9 Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder
40001 Underlying (primary) cause of death: ICD10 E24.4 Alcohol-induced pseudo-Cushing’s syndrome
40001 Underlying (primary) cause of death: ICD10 G31.2 Degeneration of nervous system due to alcohol
40001 Underlying (primary) cause of death: ICD10 G62.1 Alcoholic polyneuropathy
40001 Underlying (primary) cause of death: ICD10 G72.1 Alcoholic myopathy
40001 Underlying (primary) cause of death: ICD10 I42.6 Alcoholic cardiomyopathy
40001 Underlying (primary) cause of death: ICD10 K29.2 Alcoholic gastritis
40001 Underlying (primary) cause of death: ICD10 K70 Alcoholic liver disease
40001 Underlying (primary) cause of death: ICD10 K85.2 Alcohol-induced acute pancreatitis
40001 Underlying (primary) cause of death: ICD10 K86.0 Alcohol-induced chronic pancreatitis
40001 Underlying (primary) cause of death: ICD10 Z50.2 Alcohol rehabilitation
40001 Underlying (primary) cause of death: ICD10 Z71.4 Alcohol abuse counselling and surveillance
40002 Contributory (secondary) causes of death: ICD10 F10.1 Mental and behavioural disorders due to use of alcohol - Harmful use
40002 Contributory (secondary) causes of death: ICD10 F10.2 Mental and behavioural disorders due to use of alcohol - Dependence syndrome
40002 Contributory (secondary) causes of death: ICD10 F10.3 Mental and behavioural disorders due to use of alcohol - Withdrawal state
40002 Contributory (secondary) causes of death: ICD10 F10.4 Mental and behavioural disorders due to use of alcohol - Withdrawal state with delirium
40002 Contributory (secondary) causes of death: ICD10 F10.5 Mental and behavioural disorders due to use of alcohol - Psychotic disorder
40002 Contributory (secondary) causes of death: ICD10 F10.6 Mental and behavioural disorders due to use of alcohol - Amnesic syndrome
40002 Contributory (secondary) causes of death: ICD10 F10.7 Mental and behavioural disorders due to use of alcohol - Residual and late-onset psychotic disorder
40002 Contributory (secondary) causes of death: ICD10 F10.8 Mental and behavioural disorders due to use of alcohol - Other mental and behavioural disorders
40002 Contributory (secondary) causes of death: ICD10 F10.9 Mental and behavioural disorders due to use of alcohol - Unspecified mental and behavioural disorder
40002 Contributory (secondary) causes of death: ICD10 E24.4 Alcohol-induced pseudo-Cushing’s syndrome
40002 Contributory (secondary) causes of death: ICD10 G31.2 Degeneration of nervous system due to alcohol
40002 Contributory (secondary) causes of death: ICD10 G62.1 Alcoholic polyneuropathy
40002 Contributory (secondary) causes of death: ICD10 G72.1 Alcoholic myopathy
40002 Contributory (secondary) causes of death: ICD10 I42.6 Alcoholic cardiomyopathy
40002 Contributory (secondary) causes of death: ICD10 K29.2 Alcoholic gastritis
40002 Contributory (secondary) causes of death: ICD10 K70 Alcoholic liver disease
40002 Contributory (secondary) causes of death: ICD10 K85.2 Alcohol-induced acute pancreatitis
40002 Contributory (secondary) causes of death: ICD10 K86.0 Alcohol-induced chronic pancreatitis
40002 Contributory (secondary) causes of death: ICD10 Z50.2 Alcohol rehabilitation
40002 Contributory (secondary) causes of death: ICD10 Z71.4 Alcohol abuse counselling and surveillance
42040 GP clinical event records 136S.00 Hazardous alcohol use
42040 GP clinical event records 136T.00 Harmful alcohol use
42040 GP clinical event records 136W.00 Alcohol misuse
42040 GP clinical event records 13Y8.00 Alcoholics anonymous
42040 GP clinical event records 1462.00 H/O: alcoholism
42040 GP clinical event records 1B1c.00 Alcohol induced hallucinations
42040 GP clinical event records 66e0.00 Alcohol abuse monitoring
42040 GP clinical event records 66e..00 Alcohol disorder monitoring
42040 GP clinical event records 7P22100 Delivery of rehabilitation for alcohol addiction
42040 GP clinical event records 8BA8.00 Alcohol detoxification
42040 GP clinical event records 8CAv.00 Advised to contact primary care alcohol worker
42040 GP clinical event records 8G32.00 Aversion therapy - alcoholism
42040 GP clinical event records 8H35.00 Admitted to alcohol detoxification centre
42040 GP clinical event records 8H7p.00 Referral to community alcohol team
42040 GP clinical event records 8HkG.00 Referral to specialist alcohol treatment service
42040 GP clinical event records 8HkJ.00 Referral to alcohol brief intervention service
42040 GP clinical event records 9k12.00 Alcohol misuse - enhanced service completed
42040 GP clinical event records 9k1..00 Alcohol misuse - enhanced services administration
42040 GP clinical event records 9k1A.00 Brief intervention for excessive alcohol consumptn completed
42040 GP clinical event records 9k1B.00 Extended intervention for excessive alcohol consumptn complt
42040 GP clinical event records 9NN2.00 Under care of community alcohol team
42040 GP clinical event records C150500 Alcohol-induced pseudo-Cushing’s syndrome
42040 GP clinical event records C251.11 Wernicke’s encephalopathy
42040 GP clinical event records C253.00 Wernicke’s encephalopathy
42040 GP clinical event records E010.00 Alcohol withdrawal delirium
42040 GP clinical event records E010.11 DTs - delirium tremens
42040 GP clinical event records E010.12 Delirium tremens
42040 GP clinical event records E011000 Korsakov’s alcoholic psychosis
42040 GP clinical event records E011100 Korsakov’s alcoholic psychosis with peripheral neuritis
42040 GP clinical event records E011200 Wernicke-Korsakov syndrome
42040 GP clinical event records E011.00 Alcohol amnestic syndrome
42040 GP clinical event records E011z00 Alcohol amnestic syndrome NOS
42040 GP clinical event records E012000 Chronic alcoholic brain syndrome
42040 GP clinical event records E012.00 Other alcoholic dementia
42040 GP clinical event records E012.11 Alcoholic dementia NOS
42040 GP clinical event records E013.00 Alcohol withdrawal hallucinosis
42040 GP clinical event records E015.00 Alcoholic paranoia
42040 GP clinical event records E01..00 Alcoholic psychoses
42040 GP clinical event records E01y000 Alcohol withdrawal syndrome
42040 GP clinical event records E01y.00 Other alcoholic psychosis
42040 GP clinical event records E01yz00 Other alcoholic psychosis NOS
42040 GP clinical event records E01z.00 Alcoholic psychosis NOS
42040 GP clinical event records E230000 Acute alcoholic intoxication, unspecified, in alcoholism
42040 GP clinical event records E230100 Continuous acute alcoholic intoxication in alcoholism
42040 GP clinical event records E230200 Episodic acute alcoholic intoxication in alcoholism
42040 GP clinical event records E230300 Acute alcoholic intoxication in remission, in alcoholism
42040 GP clinical event records E230.00 Acute alcoholic intoxication in alcoholism
42040 GP clinical event records E230.11 Alcohol dependence with acute alcoholic intoxication
42040 GP clinical event records E230z00 Acute alcoholic intoxication in alcoholism NOS
42040 GP clinical event records E231000 Unspecified chronic alcoholism
42040 GP clinical event records E231100 Continuous chronic alcoholism
42040 GP clinical event records E231200 Episodic chronic alcoholism
42040 GP clinical event records E231300 Chronic alcoholism in remission
42040 GP clinical event records E231.00 Chronic alcoholism
42040 GP clinical event records E231.11 Dipsomania
42040 GP clinical event records E231z00 Chronic alcoholism NOS
42040 GP clinical event records E23..00 Alcohol dependence syndrome
42040 GP clinical event records E23..11 Alcoholism
42040 GP clinical event records E23..12 Alcohol problem drinking
42040 GP clinical event records E23z.00 Alcohol dependence syndrome NOS
42040 GP clinical event records Eu10100 [X]Mental and behav dis due to use of alcohol: harmful use
42040 GP clinical event records Eu10200 [X]Mental and behav dis due to use alcohol: dependence syndr
42040 GP clinical event records Eu10211 [X]Alcohol addiction
42040 GP clinical event records Eu10212 [X]Chronic alcoholism
42040 GP clinical event records Eu10213 [X]Dipsomania
42040 GP clinical event records Eu10300 [X]Mental and behav dis due to use alcohol: withdrawal state
42040 GP clinical event records Eu10400 [X]Men & behav dis due alcohl: withdrawl state with delirium
42040 GP clinical event records Eu10411 [X]Delirium tremens, alcohol induced
42040 GP clinical event records Eu10500 [X]Mental & behav dis due to use alcohol: psychotic disorder
42040 GP clinical event records Eu10511 [X]Alcoholic hallucinosis
42040 GP clinical event records Eu10512 [X]Alcoholic jealousy
42040 GP clinical event records Eu10513 [X]Alcoholic paranoia
42040 GP clinical event records Eu10514 [X]Alcoholic psychosis NOS
42040 GP clinical event records Eu10600 [X]Mental and behav dis due to use alcohol: amnesic syndrome
42040 GP clinical event records Eu10611 [X]Korsakov’s psychosis, alcohol induced
42040 GP clinical event records Eu10700 [X]Men & behav dis due alcoh: resid & late-onset psychot dis
42040 GP clinical event records Eu10711 [X]Alcoholic dementia NOS
42040 GP clinical event records Eu10712 [X]Chronic alcoholic brain syndrome
42040 GP clinical event records Eu10800 [X]Alcohol withdrawal-induced seizure
42040 GP clinical event records Eu10.00 [X]Mental and behavioural disorders due to use of alcohol
42040 GP clinical event records Eu10y00 [X]Men & behav dis due to use alcohol: oth men & behav dis
42040 GP clinical event records Eu10z00 [X]Ment & behav dis due use alcohol: unsp ment & behav dis
42040 GP clinical event records F11x000 Cerebral degeneration due to alcoholism
42040 GP clinical event records F11x011 Alcoholic encephalopathy
42040 GP clinical event records F144000 Cerebellar ataxia due to alcoholism
42040 GP clinical event records F25B.00 Alcohol-induced epilepsy
42040 GP clinical event records F375.00 Alcoholic polyneuropathy
42040 GP clinical event records F394100 Alcoholic myopathy
42040 GP clinical event records G555.00 Alcoholic cardiomyopathy
42040 GP clinical event records G852300 Oesophageal varices in alcoholic cirrhosis of the liver
42040 GP clinical event records J153.00 Alcoholic gastritis
42040 GP clinical event records J610.00 Alcoholic fatty liver
42040 GP clinical event records J611.00 Acute alcoholic hepatitis
42040 GP clinical event records J612000 Alcoholic fibrosis and sclerosis of liver
42040 GP clinical event records J612.00 Alcoholic cirrhosis of liver
42040 GP clinical event records J613000 Alcoholic hepatic failure
42040 GP clinical event records J613.00 Alcoholic liver damage unspecified
42040 GP clinical event records J617000 Chronic alcoholic hepatitis
42040 GP clinical event records J617.00 Alcoholic hepatitis
42040 GP clinical event records J670800 Alcohol-induced acute pancreatitis
42040 GP clinical event records J671000 Alcohol-induced chronic pancreatitis
42040 GP clinical event records Z191100 Alcohol withdrawal regime
42040 GP clinical event records Z191200 Planned reduction of alcohol consumption
42040 GP clinical event records Z191211 Alcohol reduction programme
42040 GP clinical event records Z191.00 Alcohol detoxification
42040 GP clinical event records Z4B1.00 Alcoholism counselling
42040 GP clinical event records ZV11300 [V]Personal history of alcoholism
42040 GP clinical event records ZV11311 [V]Problems related to lifestyle alcohol use
42040 GP clinical event records ZV57A00 [V]Alcohol rehabilitation
42040 GP clinical event records ZV6D600 [V]Alcohol abuse counselling and surveillance
42040 GP clinical event records XE0b4 Alcoholic cirrhosis of liver
42040 GP clinical event records XaPmB Advised to contact primary care alcohol worker
42040 GP clinical event records X709V Alcoholic myopathy
42040 GP clinical event records X308v Alcohol-induced chronic pancreatitis
42040 GP clinical event records XE1ZE [X]Mental and behavioural disorders due to use of alcohol: dependence syndrome
42040 GP clinical event records XE1ZE [X]Mental and behavioural disorders due to use of alcohol: dependence syndrome
42040 GP clinical event records XaJni Alcohol disorder monitoring
42040 GP clinical event records XaPPv Brief intervention for excessive alcohol consumption completed
42040 GP clinical event records XaPPy Extended intervention for excessive alcohol consumption completed
42040 GP clinical event records XaLrN Alcohol abuse monitoring
42040 GP clinical event records XaKvB Harmful alcohol use
42040 GP clinical event records XaKvA Hazardous alcohol use
42040 GP clinical event records XE1ZG [X]Mental and behavioural disorders due to use of alcohol: residual and late-onset psychotic disorder
42040 GP clinical event records XE1ZF [X]Mental and behavioural disorders due to use of alcohol: psychotic disorder
42040 GP clinical event records XE1ZF [X]Mental and behavioural disorders due to use of alcohol: psychotic disorder
42040 GP clinical event records XE1ZF [X]Mental and behavioural disorders due to use of alcohol: psychotic disorder
42040 GP clinical event records XaLsx Delivery of rehabilitation for alcohol addiction
42040 GP clinical event records XaBE3 Chronic alcoholic hepatitis
42040 GP clinical event records XaIPn Referral to community alcohol team
42040 GP clinical event records XaORR Referral to specialist alcohol treatment service
42040 GP clinical event records X308j Alcohol-induced acute pancreatitis
42040 GP clinical event records X006u Alcohol-induced epilepsy
42040 GP clinical event records XaC1d Oesophageal varices in alcoholic cirrhosis of the liver
42040 GP clinical event records XaIN4 Under care of community alcohol team
42040 GP clinical event records XaPna Referral to alcohol brief intervention service
42040 GP clinical event records XE1YQ Chronic alcoholism
42040 GP clinical event records X40MG Alcohol-induced pseudo-Cushing’s syndrome
42040 GP clinical event records XaLWu [X]Alcohol withdrawal-induced seizure
42040 GP clinical event records XE110 Other and unspecified thiamine (vitamin B1) deficiency states
42040 GP clinical event records X3073 Alcoholic hepatic failure
42040 GP clinical event records X3072 Alcoholic fibrosis and sclerosis of liver
42040 GP clinical event records XaKV2 Alcohol induced hallucinations
42040 GP clinical event records X306r Alcoholic hepatitis
42040 GP clinical event records XE1Xu Other alcoholic dementia