Allergic and chronic rhinitis

Metadata

Name	Allergic and chronic rhinitis (allergic_rhinitis)
Category	Respiratory
Sex
Adult	Yes
UUID	791075ad-ad39-4309-bfae-6af9ec5d02e3
Definition	Allergic rhinitis is inflammation of the inside of the nose caused by an allergen, such as pollen, dust, mould or flakes of skin from certain animals.

Ontologies

Disease Ontology (DOID)	DOID_4481
GWAS Catalogue	EFO_0005854
MeSH	D065631
SNOMED-CT	61582004
FinnGen	ALLERG_RHINITIS

Key Summary Statistics

Cases from any source

Total	142237
Female (%)	82436 (58%)
Male (%)	59801 (42%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	3007.76 (2976.9,3038.62)
Male	2630.19 (2597.91,2662.48)

Incidence stratified by sex

Female	39.65 (37.69,41.62)
Male	40.4 (38.28,42.52)

Incidence stratified by age

Ages 40-44	36.59 (31.93,41.25)
Ages 45-49	36.97 (32.97,40.96)
Ages 50-54	34.2 (30.72,37.69)
Ages 55-59	38.06 (34.76,41.35)
Ages 60-64	45.22 (42.2,48.24)
Ages 65-69	42.57 (39.28,45.87)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1367 (1332,1404)	1320 (1292,1348)	1296 (1273,1320)
CALIBER	1602 (1591,1612)	1517 (1506,1529)	1492 (1480,1504)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	1419(1333,1509)	1398(1334,1464)	1323(1272,1375)
Low	1390(1304,1480)	1368(1305,1434)	1352(1301,1404)
Medium	1333(1253,1418)	1345(1283,1409)	1260(1210,1312)
High	1393(1317,1472)	1274(1214,1336)	1266(1214,1321)
Most deprived	1318(1249,1389)	1224(1166,1284)	1271(1216,1328)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	1336(1297,1376)	1326(1295,1358)	1317(1291,1344)
Scotland	1297(1198,1402)	1128(1059,1201)	969(911,1030)
Wales	1847(1696,2007)	1581(1476,1692)	1582(1490,1679)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153513, Events=116

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.85 (1.14, 2.99)	0.0128
BMI	obese	1.9 (1.12, 3.22)	0.0174
BMI	underweight	0 (0, Inf)	0.993
smoking	previous	0.82 (0.53, 1.27)	0.367
smoking	current	1.79 (1.09, 2.95)	0.0215
hypertension	yes	1.55 (1.01, 2.37)	0.0432

Definition

UK Biobank field id	Description	Code	Value
6152	Blood clot, DVT, bronchitis, emphysema, asthma, rhinitis, eczema, allergy diagnosed by doctor	9	Hayfever, allergic rhinitis or eczema
20002	Non-cancer illness code, self-reported	1387	hayfever/allergic rhinitis
20002	Non-cancer illness code, self-reported	1668	allergy to house dust mite
41202	Diagnoses - main ICD10	J30.1	Allergic rhinitis due to pollen
41202	Diagnoses - main ICD10	J30.2	Other seasonal allergic rhinitis
41202	Diagnoses - main ICD10	J30.3	Other allergic rhinitis
41202	Diagnoses - main ICD10	J30.4	Allergic rhinitis, unspecified
41202	Diagnoses - main ICD10	J31.0	Chronic rhinitis
41204	Diagnoses - secondary ICD10	J30.1	Allergic rhinitis due to pollen
41204	Diagnoses - secondary ICD10	J30.2	Other seasonal allergic rhinitis
41204	Diagnoses - secondary ICD10	J30.3	Other allergic rhinitis
41204	Diagnoses - secondary ICD10	J30.4	Allergic rhinitis, unspecified
41204	Diagnoses - secondary ICD10	J31.0	Chronic rhinitis
40001	Underlying (primary) cause of death: ICD10	J30.1	Allergic rhinitis due to pollen
40001	Underlying (primary) cause of death: ICD10	J30.2	Other seasonal allergic rhinitis
40001	Underlying (primary) cause of death: ICD10	J30.3	Other allergic rhinitis
40001	Underlying (primary) cause of death: ICD10	J30.4	Allergic rhinitis, unspecified
40001	Underlying (primary) cause of death: ICD10	J31.0	Chronic rhinitis
40002	Contributory (secondary) causes of death: ICD10	J30.1	Allergic rhinitis due to pollen
40002	Contributory (secondary) causes of death: ICD10	J30.2	Other seasonal allergic rhinitis
40002	Contributory (secondary) causes of death: ICD10	J30.3	Other allergic rhinitis
40002	Contributory (secondary) causes of death: ICD10	J30.4	Allergic rhinitis, unspecified
40002	Contributory (secondary) causes of death: ICD10	J31.0	Chronic rhinitis
42040	GP clinical event records	14B1.00	H/O: hay fever
42040	GP clinical event records	H120000	Chronic simple rhinitis
42040	GP clinical event records	H120100	Chronic catarrhal rhinitis
42040	GP clinical event records	H120200	Chronic hypertrophic rhinitis
42040	GP clinical event records	H120300	Chronic atrophic rhinitis
42040	GP clinical event records	H120400	Chronic infective rhinitis
42040	GP clinical event records	H120500	Chronic ulcerative rhinitis
42040	GP clinical event records	H120600	Chronic membranous rhinitis
42040	GP clinical event records	H120700	Chronic fibrinous rhinitis
42040	GP clinical event records	H120.00	Chronic rhinitis
42040	GP clinical event records	H120z00	Chronic rhinitis NOS
42040	GP clinical event records	H13..11	Chronic rhinosinusitis
42040	GP clinical event records	H170.00	Allergic rhinitis due to pollens
42040	GP clinical event records	H170.11	Hay fever - pollens
42040	GP clinical event records	H170.12	Pollinosis
42040	GP clinical event records	H171000	Allergy to animal
42040	GP clinical event records	H171100	Dog allergy
42040	GP clinical event records	H171.00	Allergic rhinitis due to other allergens
42040	GP clinical event records	H171.11	Cat allergy
42040	GP clinical event records	H171.12	Dander (animal) allergy
42040	GP clinical event records	H171.13	Feather allergy
42040	GP clinical event records	H171.14	Hay fever - other allergen
42040	GP clinical event records	H171.15	House dust allergy
42040	GP clinical event records	H171.16	House dust mite allergy
42040	GP clinical event records	H172.00	Allergic rhinitis due to unspecified allergen
42040	GP clinical event records	H172.11	Hay fever - unspecified allergen
42040	GP clinical event records	H17..00	Allergic rhinitis
42040	GP clinical event records	H17..11	Perennial rhinitis
42040	GP clinical event records	H17..12	Allergic rhinosinusitis
42040	GP clinical event records	H17z.00	Allergic rhinitis NOS
42040	GP clinical event records	H18..00	Vasomotor rhinitis
42040	GP clinical event records	H330011	Hay fever with asthma
42040	GP clinical event records	H330.13	Hay fever with asthma
42040	GP clinical event records	Hyu2000	[X]Other seasonal allergic rhinitis
42040	GP clinical event records	Hyu2100	[X]Other allergic rhinitis
42040	GP clinical event records	XE0Y7	Allergic rhinitis due to unspecified allergen
42040	GP clinical event records	XE0Y6	Allergic rhinitis due to other allergens
42040	GP clinical event records	XE0Xy	Chronic catarrhal rhinitis
42040	GP clinical event records	XE2QI	Allergic rhinitis due to pollens
42040	GP clinical event records	XE2QI	Allergic rhinitis due to pollens
42040	GP clinical event records	XaIpW	Allergy to animal
42040	GP clinical event records	XE0Xx	Chronic rhinitis
42040	GP clinical event records	XE0Xx	Chronic rhinitis
42040	GP clinical event records	XE0Y5	Allergic rhinitis
42040	GP clinical event records	XE0YR	Extrinsic asthma without status asthmaticus
22126	Doctor diagnosed hayfever or allergic rhinitis	1	yes
22166	Recent medication for hayfever or allergic rhinitis	1	yes