| Name |
Alopecia areata (alopecia_areata) |
| Category |
Skin |
| Sex |
|
| Adult |
Yes |
| UUID |
483ef0ba-73a6-462c-b1d2-941b32b41a86 |
| Definition |
Alopecia areata is a common autoimmune disorder that often results in unpredictable hair loss. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1079 |
| Female (%) |
703 (65%) |
| Male (%) |
376 (35%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
35.95 (31.92,39.98) |
| Male |
24.36 (20.74,27.97) |
Incidence stratified by sex
| Female |
1.48 (1.16,1.8) |
| Male |
0.89 (0.62,1.15) |
Incidence stratified by age
| Ages 40-44 |
1.71 (0.9,2.53) |
| Ages 45-49 |
1.94 (1.19,2.68) |
| Ages 50-54 |
1.27 (0.71,1.83) |
| Ages 55-59 |
0.94 (0.5,1.37) |
| Ages 60-64 |
1.04 (0.65,1.43) |
| Ages 65-69 |
0.91 (0.49,1.32) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
43 (37,49) |
38 (34,43) |
32 (28,36) |
| CALIBER |
49 (47,51) |
46 (44,48) |
38 (36,40) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
36(23,53) |
39(29,52) |
32(24,41) |
| Low |
30(18,46) |
32(23,43) |
27(20,35) |
| Medium |
37(25,54) |
43(32,55) |
35(28,45) |
| High |
61(46,80) |
34(25,45) |
29(21,38) |
| Most deprived |
45(33,60) |
44(34,56) |
37(28,48) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
44(37,52) |
42(36,48) |
32(28,36) |
| Scotland |
40(24,62) |
26(17,39) |
34(24,47) |
| Wales |
33(16,61) |
24(13,40) |
27(17,43) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153595, Events=126
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.75 (0.51, 1.1) |
0.143 |
| BMI |
obese |
0.53 (0.31, 0.88) |
0.014 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.05 (0.71, 1.56) |
0.804 |
| smoking |
current |
1.31 (0.76, 2.25) |
0.339 |
| hypertension |
yes |
1.64 (1.09, 2.47) |
0.0186 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1667 |
alopecia |
| 41202 |
Diagnoses - main ICD10 |
L63 |
Alopecia areata |
| 41204 |
Diagnoses - secondary ICD10 |
L63 |
Alopecia areata |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L63 |
Alopecia areata |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L63 |
Alopecia areata |
| 42040 |
GP clinical event records |
M240100 |
Alopecia areata |
| 42040 |
GP clinical event records |
M240111 |
Ophiasis |
| 42040 |
GP clinical event records |
M240B00 |
Alopecia totalis |
| 42040 |
GP clinical event records |
M240K00 |
Alopecia universalis |
| 42040 |
GP clinical event records |
M240U00 |
Ophiasis |
| 42040 |
GP clinical event records |
Myu6200 |
[X]Other alopecia areata |
| 42040 |
GP clinical event records |
X509h |
Alopecia universalis |
| 42040 |
GP clinical event records |
XE1BH |
Alopecia areata |