Metadata
| Name | Alzheimer’s disease (alzheimer) |
| Category | Psychiatric |
| Sex | |
| Adult | Yes |
| UUID | 43a6b12f-72ea-46f3-a025-3c82247cc707 |
| Definition | A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities. |
Ontologies
| Disease Ontology (DOID) | DOID_10652 |
| GWAS Catalogue | MONDO_0004975 |
| MeSH | D000544 |
| SNOMED-CT | 26929004 |
| FinnGen | G6_ALZHEIMER |
Key Summary Statistics
Cases from any source
| Total | 3215 |
| Female (%) | 1660 (52%) |
| Male (%) | 1555 (48%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 1.3 (0.53,2.06) |
| Male | 1.12 (0.34,1.9) |
Incidence stratified by sex
| Female | 3.43 (2.95,3.91) |
| Male | 4.11 (3.53,4.68) |
Incidence stratified by age
| Ages 40-44 | 0.1 (-0.1,0.3) |
| Ages 45-49 | 0.15 (-0.06,0.35) |
| Ages 50-54 | 0.63 (0.24,1.03) |
| Ages 55-59 | 1.71 (1.13,2.3) |
| Ages 60-64 | 4.99 (4.14,5.85) |
| Ages 65-69 | 10.76 (9.32,12.21) |
Period prevalence
Methods
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 1 (0,2) | 8 (6,10) | 41 (37,46) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 1(0,7) | 7(3,14) | 41(32,51) |
| Low | 0(NaN,NaN) | 6(3,12) | 36(28,46) |
| Medium | 0(NaN,NaN) | 10(5,17) | 41(32,51) |
| High | 1(0,6) | 9(5,16) | 38(30,49) |
| Most deprived | 1(0,6) | 6(3,12) | 52(41,64) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 1(0,3) | 8(6,11) | 39(35,44) |
| Scotland | 0(NaN,NaN) | 8(3,17) | 53(41,69) |
| Wales | 3(0,17) | 3(0,12) | 44(30,63) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=152960, Events=163
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.3 (0.88, 1.92) | 0.185 |
| BMI | obese | 1.75 (1.16, 2.63) | 0.00738 |
| BMI | underweight | 0 (0, Inf) | 0.991 |
| smoking | previous | 1.02 (0.7, 1.49) | 0.904 |
| smoking | current | 3.45 (2.37, 5.02) | 8.66e-11 |
| hypertension | yes | 1.36 (0.94, 1.95) | 0.101 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 41202 | Diagnoses - main ICD10 | F00 | Dementia in Alzheimer’s disease |
| 41202 | Diagnoses - main ICD10 | G30 | Alzheimer’s disease |
| 41204 | Diagnoses - secondary ICD10 | F00 | Dementia in Alzheimer’s disease |
| 41204 | Diagnoses - secondary ICD10 | G30 | Alzheimer’s disease |
| 40001 | Underlying (primary) cause of death: ICD10 | F00 | Dementia in Alzheimer’s disease |
| 40001 | Underlying (primary) cause of death: ICD10 | G30 | Alzheimer’s disease |
| 40002 | Contributory (secondary) causes of death: ICD10 | F00 | Dementia in Alzheimer’s disease |
| 40002 | Contributory (secondary) causes of death: ICD10 | G30 | Alzheimer’s disease |
| 42040 | GP clinical event records | Eu00000 | [X]Dementia in Alzheimer’s disease with early onset |
| 42040 | GP clinical event records | Eu00011 | [X]Presenile dementia,Alzheimer’s type |
| 42040 | GP clinical event records | Eu00012 | [X]Primary degen dementia, Alzheimer’s type, presenile onset |
| 42040 | GP clinical event records | Eu00013 | [X]Alzheimer’s disease type 2 |
| 42040 | GP clinical event records | Eu00100 | [X]Dementia in Alzheimer’s disease with late onset |
| 42040 | GP clinical event records | Eu00111 | [X]Alzheimer’s disease type 1 |
| 42040 | GP clinical event records | Eu00112 | [X]Senile dementia,Alzheimer’s type |
| 42040 | GP clinical event records | Eu00113 | [X]Primary degen dementia of Alzheimer’s type, senile onset |
| 42040 | GP clinical event records | Eu00200 | [X]Dementia in Alzheimer’s dis, atypical or mixed type |
| 42040 | GP clinical event records | Eu00.00 | [X]Dementia in Alzheimer’s disease |
| 42040 | GP clinical event records | Eu00z00 | [X]Dementia in Alzheimer’s disease, unspecified |
| 42040 | GP clinical event records | Eu00z11 | [X]Alzheimer’s dementia unspec |
| 42040 | GP clinical event records | F110000 | Alzheimer’s disease with early onset |
| 42040 | GP clinical event records | F110100 | Alzheimer’s disease with late onset |
| 42040 | GP clinical event records | F110.00 | Alzheimer’s disease |
| 42040 | GP clinical event records | Fyu3000 | [X]Other Alzheimer’s disease |
| 42040 | GP clinical event records | XaIKB | Alzheimer’s disease with early onset |
| 42040 | GP clinical event records | XaIKC | Alzheimer’s disease with late onset |