| Name |
Anal fissure (anal_fissure) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
5b765325-09fa-4020-aa56-7664ff0813b4 |
| Definition |
A painful linear tear at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
8883 |
| Female (%) |
4434 (50%) |
| Male (%) |
4449 (50%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
191.55 (182.33,200.77) |
| Male |
211.53 (200.98,222.08) |
Incidence stratified by sex
| Female |
9.61 (8.8,10.43) |
| Male |
12.56 (11.54,13.58) |
Incidence stratified by age
| Ages 40-44 |
14.65 (12.24,17.05) |
| Ages 45-49 |
13.98 (11.95,16.0) |
| Ages 50-54 |
11.44 (9.75,13.13) |
| Ages 55-59 |
11.38 (9.85,12.9) |
| Ages 60-64 |
9.38 (8.19,10.57) |
| Ages 65-69 |
8.35 (7.07,9.63) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
332 (315,350) |
294 (281,308) |
255 (245,266) |
| CALIBER |
314 (309,318) |
300 (295,305) |
266 (260,271) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
331(290,375) |
272(244,302) |
255(233,279) |
| Low |
361(319,408) |
283(255,314) |
264(241,287) |
| Medium |
303(266,345) |
309(280,341) |
240(218,263) |
| High |
331(295,371) |
301(272,332) |
246(223,271) |
| Most deprived |
331(296,367) |
304(275,335) |
275(249,302) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
346(326,366) |
307(292,323) |
265(254,278) |
| Scotland |
207(169,250) |
218(188,252) |
179(154,207) |
| Wales |
392(324,470) |
295(250,346) |
267(230,309) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153979, Events=141
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.41 (0.92, 2.17) |
0.113 |
| BMI |
obese |
1.52 (0.95, 2.43) |
0.0832 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
0.89 (0.63, 1.27) |
0.531 |
| smoking |
current |
0.83 (0.44, 1.56) |
0.561 |
| hypertension |
yes |
1.5 (1.06, 2.12) |
0.0207 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1504 |
anal fissure |
| 41202 |
Diagnoses - main ICD10 |
K60.0 |
Acute anal fissure |
| 41202 |
Diagnoses - main ICD10 |
K60.1 |
Chronic anal fissure |
| 41202 |
Diagnoses - main ICD10 |
K60.2 |
Anal fissure, unspecified |
| 41204 |
Diagnoses - secondary ICD10 |
K60.0 |
Acute anal fissure |
| 41204 |
Diagnoses - secondary ICD10 |
K60.1 |
Chronic anal fissure |
| 41204 |
Diagnoses - secondary ICD10 |
K60.2 |
Anal fissure, unspecified |
| 41200 |
Operative procedures - main OPCS4 |
H56.4 |
Excision of anal fissure |
| 41210 |
Operative procedures - secondary OPCS4 |
H56.4 |
H56.4 |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K60.0 |
Acute anal fissure |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K60.1 |
Chronic anal fissure |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K60.2 |
Anal fissure, unspecified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K60.0 |
Acute anal fissure |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K60.1 |
Chronic anal fissure |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K60.2 |
Anal fissure, unspecified |
| 42040 |
GP clinical event records |
7739300.0 |
Excision of anal fissure |
| 42040 |
GP clinical event records |
J530000 |
Acute anal fissure |
| 42040 |
GP clinical event records |
J530100 |
Chronic anal fissure |
| 42040 |
GP clinical event records |
J530.00 |
Anal fissure |
| 42040 |
GP clinical event records |
J530.11 |
Tear of anus - non-traumatic |
| 42040 |
GP clinical event records |
J53..00 |
Anal fissure and fistula |
| 42040 |
GP clinical event records |
J53z.00 |
Anal fissure and fistula NOS |
| 42040 |
GP clinical event records |
J544.00 |
Ano-rectal fissure abscess |