Infection of anal and rectal regions

Metadata

Name	Infection of anal and rectal regions (anorectal)
Category	Infections
Sex
Adult	Yes
UUID	908b9c1e-7768-4d02-829f-7dbb3a3b3848
Definition	Infection of anal and rectal regions

Ontologies

SNOMED-CT

371568002

Key Summary Statistics

Cases from any source

Total	2362
Female (%)	837 (35%)
Male (%)	1525 (65%)

Year first recorded

Cases linked in all UK Biobank sources

*All 941 cases from Hospital EHR*

Incidence & prevalence

Baseline prevalence stratified by sex

Female	17.56 (14.75,20.38)
Male	39.06 (34.48,43.63)

Incidence stratified by sex

Female	1.27 (0.97,1.56)
Male	2.47 (2.02,2.92)

Incidence stratified by age

Ages 40-44	3.13 (2.03,4.23)
Ages 45-49	2.53 (1.68,3.38)
Ages 50-54	1.91 (1.22,2.59)
Ages 55-59	1.15 (0.67,1.63)
Ages 60-64	1.58 (1.09,2.06)
Ages 65-69	1.56 (1.01,2.11)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	53 (46,60)	48 (43,54)	32 (28,36)
CALIBER	57 (55,59)	49 (47,52)	37 (35,39)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	50(35,70)	43(32,56)	28(21,36)
Low	37(24,55)	35(26,47)	22(16,30)
Medium	53(38,72)	41(30,54)	27(20,36)
High	56(41,74)	49(38,63)	39(30,50)
Most deprived	63(49,80)	72(58,88)	46(36,58)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	50(43,58)	45(40,52)	32(28,36)
Scotland	80(57,110)	67(51,87)	38(27,52)
Wales	37(19,67)	46(29,69)	24(14,39)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.18 (0.74, 1.86)	0.489
BMI	obese	1.91 (1.2, 3.06)	0.00685
BMI	underweight	0 (0, Inf)	0.995
smoking	previous	1.29 (0.88, 1.87)	0.189
smoking	current	1.41 (0.81, 2.45)	0.23
hypertension	yes	1.93 (1.34, 2.77)	0.000403

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	A51.1	Primary anal syphilis
41202	Diagnoses - main ICD10	A54.6	Gonococcal infection of anus and rectum
41202	Diagnoses - main ICD10	A56.3	Chlamydial infection of anus and rectum
41202	Diagnoses - main ICD10	A60.1	Herpesviral infection of perianal skin and rectum
41202	Diagnoses - main ICD10	A60.9	Anogenital herpesviral infection, unspecified
41202	Diagnoses - main ICD10	A63.0	Anogenital (venereal) warts
41202	Diagnoses - main ICD10	K61	Abscess of anal and rectal regions
41204	Diagnoses - secondary ICD10	A51.1	Primary anal syphilis
41204	Diagnoses - secondary ICD10	A54.6	Gonococcal infection of anus and rectum
41204	Diagnoses - secondary ICD10	A56.3	Chlamydial infection of anus and rectum
41204	Diagnoses - secondary ICD10	A60.1	Herpesviral infection of perianal skin and rectum
41204	Diagnoses - secondary ICD10	A60.9	Anogenital herpesviral infection, unspecified
41204	Diagnoses - secondary ICD10	A63.0	Anogenital (venereal) warts
41204	Diagnoses - secondary ICD10	K61	Abscess of anal and rectal regions
40001	Underlying (primary) cause of death: ICD10	A51.1	Primary anal syphilis
40001	Underlying (primary) cause of death: ICD10	A54.6	Gonococcal infection of anus and rectum
40001	Underlying (primary) cause of death: ICD10	A56.3	Chlamydial infection of anus and rectum
40001	Underlying (primary) cause of death: ICD10	A60.1	Herpesviral infection of perianal skin and rectum
40001	Underlying (primary) cause of death: ICD10	A60.9	Anogenital herpesviral infection, unspecified
40001	Underlying (primary) cause of death: ICD10	A63.0	Anogenital (venereal) warts
40001	Underlying (primary) cause of death: ICD10	K61	Abscess of anal and rectal regions
40002	Contributory (secondary) causes of death: ICD10	A51.1	Primary anal syphilis
40002	Contributory (secondary) causes of death: ICD10	A54.6	Gonococcal infection of anus and rectum
40002	Contributory (secondary) causes of death: ICD10	A56.3	Chlamydial infection of anus and rectum
40002	Contributory (secondary) causes of death: ICD10	A60.1	Herpesviral infection of perianal skin and rectum
40002	Contributory (secondary) causes of death: ICD10	A60.9	Anogenital herpesviral infection, unspecified
40002	Contributory (secondary) causes of death: ICD10	A63.0	Anogenital (venereal) warts
40002	Contributory (secondary) causes of death: ICD10	K61	Abscess of anal and rectal regions