Anterior and Intermediate Uveitis

Metadata

Name	Anterior and Intermediate Uveitis (ant_uveitis)
Category	Eye
Sex
Adult	Yes
UUID	5ca8d7a1-4a84-497e-a7b4-b2e5285a14c1
Definition	Inflammation of the iris and anterior chamber of the eye.

Ontologies

Disease Ontology (DOID)	DOID_1407
GWAS Catalogue	EFO_1000811
MeSH	D014606
SNOMED-CT	410692006

Key Summary Statistics

Cases from any source

Total	2787
Female (%)	1478 (53%)
Male (%)	1309 (47%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	57.64 (52.55,62.74)
Male	71.12 (64.95,77.28)

Incidence stratified by sex

Female	3.11 (2.65,3.57)
Male	2.42 (1.97,2.86)

Incidence stratified by age

Ages 40-44	2.02 (1.13,2.91)
Ages 45-49	2.69 (1.81,3.56)
Ages 50-54	2.99 (2.14,3.85)
Ages 55-59	2.83 (2.07,3.58)
Ages 60-64	3.33 (2.62,4.03)
Ages 65-69	2.38 (1.7,3.06)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	61 (54,69)	85 (78,92)	87 (81,93)
CALIBER	75 (73,78)	105 (102,108)	123 (120,127)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	44(30,62)	75(61,92)	90(77,104)
Low	63(46,84)	81(67,98)	92(79,106)
Medium	69(52,90)	81(66,98)	86(73,100)
High	65(49,84)	92(76,109)	87(73,102)
Most deprived	64(49,81)	95(79,113)	79(66,95)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	56(48,65)	75(68,83)	82(75,88)
Scotland	74(52,102)	105(85,128)	103(85,125)
Wales	95(63,137)	147(116,184)	119(94,148)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=144148, Events=6009

Factor	Level	Hazard Ratio	P value
BMI	overweight	11.38 (9.13, 14.19)	5.4799999999999994e-104
BMI	obese	105.81 (85.37, 131.15)	0.0
BMI	underweight	0.72 (0.1, 5.2)	0.748
smoking	previous	1.24 (1.17, 1.31)	3.31e-14
smoking	current	1.26 (1.16, 1.36)	8.24e-08
hypertension	yes	2.26 (2.13, 2.39)	1.3899999999999998e-180

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1530	iritis
41202	Diagnoses - main ICD10	H20.0	Acute and subacute iridocyclitis
41202	Diagnoses - main ICD10	H20.1	Chronic iridocyclitis
41202	Diagnoses - main ICD10	H20.2	Lens-induced iridocyclitis
41202	Diagnoses - main ICD10	H20.8	Other iridocyclitis
41202	Diagnoses - main ICD10	H20.9	Iridocyclitis, unspecified
41202	Diagnoses - main ICD10	H22.0	Iridocyclitis in infectious and parasitic diseases classified elsewhere
41202	Diagnoses - main ICD10	H22.1	Iridocyclitis in other diseases classified elsewhere
41202	Diagnoses - main ICD10	H30.2	Posterior cyclitis
41204	Diagnoses - secondary ICD10	H20.0	Acute and subacute iridocyclitis
41204	Diagnoses - secondary ICD10	H20.1	Chronic iridocyclitis
41204	Diagnoses - secondary ICD10	H20.2	Lens-induced iridocyclitis
41204	Diagnoses - secondary ICD10	H20.8	Other iridocyclitis
41204	Diagnoses - secondary ICD10	H20.9	Iridocyclitis, unspecified
41204	Diagnoses - secondary ICD10	H22.0	Iridocyclitis in infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	H22.1	Iridocyclitis in other diseases classified elsewhere
41204	Diagnoses - secondary ICD10	H30.2	Posterior cyclitis
40001	Underlying (primary) cause of death: ICD10	H20.0	Acute and subacute iridocyclitis
40001	Underlying (primary) cause of death: ICD10	H20.1	Chronic iridocyclitis
40001	Underlying (primary) cause of death: ICD10	H20.2	Lens-induced iridocyclitis
40001	Underlying (primary) cause of death: ICD10	H20.8	Other iridocyclitis
40001	Underlying (primary) cause of death: ICD10	H20.9	Iridocyclitis, unspecified
40001	Underlying (primary) cause of death: ICD10	H22.0	Iridocyclitis in infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	H22.1	Iridocyclitis in other diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	H30.2	Posterior cyclitis
40002	Contributory (secondary) causes of death: ICD10	H20.0	Acute and subacute iridocyclitis
40002	Contributory (secondary) causes of death: ICD10	H20.1	Chronic iridocyclitis
40002	Contributory (secondary) causes of death: ICD10	H20.2	Lens-induced iridocyclitis
40002	Contributory (secondary) causes of death: ICD10	H20.8	Other iridocyclitis
40002	Contributory (secondary) causes of death: ICD10	H20.9	Iridocyclitis, unspecified
40002	Contributory (secondary) causes of death: ICD10	H22.0	Iridocyclitis in infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	H22.1	Iridocyclitis in other diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	H30.2	Posterior cyclitis
42040	GP clinical event records	1486.00	H/O: iritis
42040	GP clinical event records	A173300	Tuberculous chronic iridocyclitis
42040	GP clinical event records	A532200	Herpes zoster iridocyclitis
42040	GP clinical event records	A544400	Herpes simplex iridocyclitis
42040	GP clinical event records	A984100	Gonococcal iridocyclitis
42040	GP clinical event records	C34y300	Gouty iritis
42040	GP clinical event records	F432300	Posterior cyclitis
42040	GP clinical event records	F432311	Pars planitis
42040	GP clinical event records	F440000	Unspecified acute iridocyclitis
42040	GP clinical event records	F440100	Unspecified subacute iridocyclitis
42040	GP clinical event records	F440200	Primary iridocyclitis
42040	GP clinical event records	F440300	Recurrent iridocyclitis
42040	GP clinical event records	F440400	Secondary infected iridocyclitis
42040	GP clinical event records	F440500	Secondary noninfected iridocyclitis
42040	GP clinical event records	F440600	Hypopyon
42040	GP clinical event records	F440700	Diabetic iritis
42040	GP clinical event records	F440.00	Acute and subacute iridocyclitis
42040	GP clinical event records	F440.11	Iritis - acute
42040	GP clinical event records	F440z00	Acute or subacute iritis NOS
42040	GP clinical event records	F441000	Unspecified chronic iridocyclitis
42040	GP clinical event records	F441100	Chronic iridocyclitis due to disease EC
42040	GP clinical event records	F441200	Chronic anterior uveitis
42040	GP clinical event records	F441.00	Chronic iridocyclitis
42040	GP clinical event records	F441.11	Chronic iritis
42040	GP clinical event records	F441z00	Chronic iridocyclitis NOS
42040	GP clinical event records	F442000	Fuchs’ heterochromic cyclitis
42040	GP clinical event records	F442100	Glaucomatocyclitic crises
42040	GP clinical event records	F442200	Lens-induced iridocyclitis
42040	GP clinical event records	F442.00	Certain types of iridocyclitis
42040	GP clinical event records	F442z00	Certain types of cyclitis NOS
42040	GP clinical event records	F443000	Anterior uveitis
42040	GP clinical event records	F443100	Iritis
42040	GP clinical event records	F443.00	Unspecified iridocyclitis
42040	GP clinical event records	F443.11	Uveitis NOS
42040	GP clinical event records	F44..12	Iridocyclitis
42040	GP clinical event records	XaF43	Posterior cyclitis
42040	GP clinical event records	XE167	Acute and subacute iridocyclitis
42040	GP clinical event records	XE16A	Unspecified iridocyclitis
42040	GP clinical event records	XaBM3	Chronic anterior uveitis
42040	GP clinical event records	X00be	Anterior uveitis