Anxiety disorders

Metadata

Name	Anxiety disorders (anxiety)
Category	Psychiatric
Sex
Adult	Yes
UUID	486d9653-9ee7-42e5-ae4e-cd61ae826d92
Definition	A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Ontologies

Disease Ontology (DOID)	DOID_2030
GWAS Catalogue	EFO_0006788
MeSH	D001008
SNOMED-CT	197480006
FinnGen	F5_ALLANXIOUS

Key Summary Statistics

Cases from any source

Total	91720
Female (%)	60308 (66%)
Male (%)	31412 (34%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	2092.2 (2064.83,2119.58)
Male	1335.26 (1310.31,1360.2)

Incidence stratified by sex

Female	51.59 (49.47,53.71)
Male	27.97 (26.35,29.59)

Incidence stratified by age

Ages 40-44	52.37 (47.36,57.37)
Ages 45-49	43.07 (39.16,46.99)
Ages 50-54	39.45 (35.97,42.92)
Ages 55-59	36.82 (33.78,39.86)
Ages 60-64	36.87 (34.29,39.45)
Ages 65-69	40.71 (37.68,43.74)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1087 (1056,1119)	1118 (1093,1144)	1091 (1070,1113)
CALIBER	1704 (1694,	1773 (1761,	1744 (1730,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	923(855,995)	1046(991,1102)	1033(989,1079)
Low	1034(962,1110)	1034(980,1091)	1070(1025,1117)
Medium	1040(969,1114)	1110(1054,1168)	1039(994,1086)
High	1046(981,1115)	1067(1012,1123)	1089(1040,1139)
Most deprived	1305(1236,1376)	1324(1263,1386)	1256(1201,1312)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	1016(982,1050)	1051(1024,1079)	1038(1015,1061)
Scotland	1267(1171,1369)	1302(1228,1378)	1232(1167,1299)
Wales	1592(1453,1741)	1464(1363,1570)	1440(1353,1532)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=152960, Events=163

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.3 (0.88, 1.92)	0.185
BMI	obese	1.75 (1.16, 2.63)	0.00738
BMI	underweight	0 (0, Inf)	0.991
smoking	previous	1.02 (0.7, 1.49)	0.904
smoking	current	3.45 (2.37, 5.02)	8.66e-11
hypertension	yes	1.36 (0.94, 1.95)	0.101

Definition

UK Biobank field id	Description	Code	Value
20544	Mental health problems ever diagnosed by a professional	15	Anxiety, nerves or generalized anxiety disorder
20428	Professional informed about anxiety	1	yes
21062	Ever been offered/sought treatment for anxiety	1	yes
20002	Non-cancer illness code, self-reported	1287	anxiety/panic attacks
41202	Diagnoses - main ICD10	F40	Phobic anxiety disorders
41202	Diagnoses - main ICD10	F41	Other anxiety disorders
41204	Diagnoses - secondary ICD10	F40	Phobic anxiety disorders
41204	Diagnoses - secondary ICD10	F41	Other anxiety disorders
40001	Underlying (primary) cause of death: ICD10	F40	Phobic anxiety disorders
40001	Underlying (primary) cause of death: ICD10	F41	Other anxiety disorders
40002	Contributory (secondary) causes of death: ICD10	F40	Phobic anxiety disorders
40002	Contributory (secondary) causes of death: ICD10	F41	Other anxiety disorders
42040	GP clinical event records	1466.00	H/O: anxiety state
42040	GP clinical event records	146G.00	H/O: agoraphobia
42040	GP clinical event records	1B1H.11	Fear
42040	GP clinical event records	1B1V.00	C/O - panic attack
42040	GP clinical event records	1Bb..00	Specific fear
42040	GP clinical event records	225J.00	O/E - panic attack
42040	GP clinical event records	225K.00	O/E - fearful mood
42040	GP clinical event records	285..00	Neurotic condition, insight present
42040	GP clinical event records	286..00	Poor insight into neurotic condition
42040	GP clinical event records	8G52.00	Antiphobic therapy
42040	GP clinical event records	8G94.00	Anxiety management training
42040	GP clinical event records	8HHp.00	Referral for guided self-help for anxiety
42040	GP clinical event records	9N54.00	Encounter for fear
42040	GP clinical event records	E200000	Anxiety state unspecified
42040	GP clinical event records	E200100	Panic disorder
42040	GP clinical event records	E200111	Panic attack
42040	GP clinical event records	E200200	Generalised anxiety disorder
42040	GP clinical event records	E200300	Anxiety with depression
42040	GP clinical event records	E200400	Chronic anxiety
42040	GP clinical event records	E200500	Recurrent anxiety
42040	GP clinical event records	E200.00	Anxiety states
42040	GP clinical event records	E200z00	Anxiety state NOS
42040	GP clinical event records	E201B00	Compensation neurosis
42040	GP clinical event records	E202000	Phobia unspecified
42040	GP clinical event records	E202100	Agoraphobia with panic attacks
42040	GP clinical event records	E202200	Agoraphobia without mention of panic attacks
42040	GP clinical event records	E202300	Social phobia, fear of eating in public
42040	GP clinical event records	E202400	Social phobia, fear of public speaking
42040	GP clinical event records	E202500	Social phobia, fear of public washing
42040	GP clinical event records	E202600	Acrophobia
42040	GP clinical event records	E202700	Animal phobia
42040	GP clinical event records	E202800	Claustrophobia
42040	GP clinical event records	E202900	Fear of crowds
42040	GP clinical event records	E202A00	Fear of flying
42040	GP clinical event records	E202B00	Cancer phobia
42040	GP clinical event records	E202C00	Dental phobia
42040	GP clinical event records	E202D00	Fear of death
42040	GP clinical event records	E202.00	Phobic disorders
42040	GP clinical event records	E202.11	Social phobic disorders
42040	GP clinical event records	E202.12	Phobic anxiety
42040	GP clinical event records	E202E00	Fear of pregnancy
42040	GP clinical event records	E202z00	Phobic disorder NOS
42040	GP clinical event records	E20..00	Neurotic disorders
42040	GP clinical event records	E20y100	Writer’s cramp neurosis
42040	GP clinical event records	E20y200	Other occupational neurosis
42040	GP clinical event records	E20y300	Psychasthenic neurosis
42040	GP clinical event records	E20y.00	Other neurotic disorders
42040	GP clinical event records	E20yz00	Other neurotic disorder NOS
42040	GP clinical event records	E20z.00	Neurotic disorder NOS
42040	GP clinical event records	Eu34111	[X]Depressive neurosis
42040	GP clinical event records	Eu34113	[X]Neurotic depression
42040	GP clinical event records	Eu34114	[X]Persistant anxiety depression
42040	GP clinical event records	Eu40000	[X]Agoraphobia
42040	GP clinical event records	Eu40011	[X]Agoraphobia without history of panic disorder
42040	GP clinical event records	Eu40012	[X]Panic disorder with agoraphobia
42040	GP clinical event records	Eu40100	[X]Social phobias
42040	GP clinical event records	Eu40112	[X]Social neurosis
42040	GP clinical event records	Eu40200	[X]Specific (isolated) phobias
42040	GP clinical event records	Eu40211	[X]Acrophobia
42040	GP clinical event records	Eu40212	[X]Animal phobias
42040	GP clinical event records	Eu40213	[X]Claustrophobia
42040	GP clinical event records	Eu40214	[X]Simple phobia
42040	GP clinical event records	Eu40300	[X]Needle phobia
42040	GP clinical event records	Eu40.00	[X]Phobic anxiety disorders
42040	GP clinical event records	Eu40y00	[X]Other phobic anxiety disorders
42040	GP clinical event records	Eu40z00	[X]Phobic anxiety disorder, unspecified
42040	GP clinical event records	Eu40z11	[X]Phobia NOS
42040	GP clinical event records	Eu40z12	[X]Phobic state NOS
42040	GP clinical event records	Eu41000	[X]Panic disorder [episodic paroxysmal anxiety]
42040	GP clinical event records	Eu41011	[X]Panic attack
42040	GP clinical event records	Eu41012	[X]Panic state
42040	GP clinical event records	Eu41100	[X]Generalized anxiety disorder
42040	GP clinical event records	Eu41111	[X]Anxiety neurosis
42040	GP clinical event records	Eu41112	[X]Anxiety reaction
42040	GP clinical event records	Eu41113	[X]Anxiety state
42040	GP clinical event records	Eu41200	[X]Mixed anxiety and depressive disorder
42040	GP clinical event records	Eu41211	[X]Mild anxiety depression
42040	GP clinical event records	Eu41300	[X]Other mixed anxiety disorders
42040	GP clinical event records	Eu41.00	[X]Other anxiety disorders
42040	GP clinical event records	Eu41y00	[X]Other specified anxiety disorders
42040	GP clinical event records	Eu41y11	[X]Anxiety hysteria
42040	GP clinical event records	Eu41z00	[X]Anxiety disorder, unspecified
42040	GP clinical event records	Eu41z11	[X]Anxiety NOS
42040	GP clinical event records	Z481.00	Phobia counselling
42040	GP clinical event records	Z4L1.00	Anxiety counselling
42040	GP clinical event records	ZV11200	[V]Personal history of neurosis
42040	GP clinical event records	XE1hk	Neurotic condition, insight present
42040	GP clinical event records	XE1YB	Phobic disorder NOS
42040	GP clinical event records	Xa7lj	Cancer phobia
42040	GP clinical event records	XE1hl	Poor insight into neurotic condition
42040	GP clinical event records	XE1Zj	[X]Other specified anxiety disorders
42040	GP clinical event records	XaIo7	C/O - panic attack
42040	GP clinical event records	XaL0q	Referral for guided self-help for anxiety
42040	GP clinical event records	XE1YE	Neurotic disorder NOS
42040	GP clinical event records	XE1YE	Neurotic disorder NOS
42040	GP clinical event records	XaK2c	H/O: agoraphobia
42040	GP clinical event records	X7627	Specific fear
42040	GP clinical event records	X762G	Fear of flying
42040	GP clinical event records	XaKVA	O/E - panic attack
42040	GP clinical event records	X762T	Fear of death
42040	GP clinical event records	XaKVN	O/E - fearful mood
42040	GP clinical event records	XE1Y7	Panic disorder
42040	GP clinical event records	Ub0qs	Anxiety management training