Aspiration pneumonitis

Metadata

Name	Aspiration pneumonitis (aspiration_pneumo)
Category	Respiratory
Sex
Adult	Yes
UUID	0b8ffb1c-f4b0-4118-8729-3e0fcfbc84e9
Definition	A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.

Ontologies

Disease Ontology (DOID)	DOID_3240
MeSH	D011015
SNOMED-CT	155597006

Key Summary Statistics

Cases from any source

Total	3113
Female (%)	1098 (35%)
Male (%)	2015 (65%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	1.53 (0.7,2.37)
Male	3.92 (2.47,5.37)

Incidence stratified by sex

Female	1.41 (1.1,1.71)
Male	3.14 (2.63,3.64)

Incidence stratified by age

Ages 40-44	0.6 (0.12,1.09)
Ages 45-49	0.89 (0.39,1.39)
Ages 50-54	1.39 (0.81,1.98)
Ages 55-59	1.61 (1.04,2.18)
Ages 60-64	2.84 (2.19,3.49)
Ages 65-69	4.22 (3.31,5.12)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	6 (4,9)	13 (10,16)	21 (18,24)
CALIBER	13 (12,14)	22 (21,24)	49 (47,51)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	6(2,15)	6(3,13)	16(10,22)
Low	6(2,15)	11(6,18)	16(11,23)
Medium	5(1,13)	15(9,23)	16(11,23)
High	5(1,12)	12(7,20)	23(16,31)
Most deprived	10(5,18)	22(14,31)	38(29,49)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	7(4,10)	14(11,18)	21(17,24)
Scotland	5(1,17)	9(4,19)	27(18,39)
Wales	7(1,27)	11(4,25)	18(9,32)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153513, Events=116

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.85 (1.14, 2.99)	0.0128
BMI	obese	1.9 (1.12, 3.22)	0.0174
BMI	underweight	0 (0, Inf)	0.993
smoking	previous	0.82 (0.53, 1.27)	0.367
smoking	current	1.79 (1.09, 2.95)	0.0215
hypertension	yes	1.55 (1.01, 2.37)	0.0432

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	J69.0	Pneumonitis due to food and vomit
41202	Diagnoses - main ICD10	J69.1	Pneumonitis due to oils and essences
41202	Diagnoses - main ICD10	J69.8	Pneumonitis due to other solids and liquids
41204	Diagnoses - secondary ICD10	J69.0	Pneumonitis due to food and vomit
41204	Diagnoses - secondary ICD10	J69.1	Pneumonitis due to oils and essences
41204	Diagnoses - secondary ICD10	J69.8	Pneumonitis due to other solids and liquids
40001	Underlying (primary) cause of death: ICD10	J69.0	Pneumonitis due to food and vomit
40001	Underlying (primary) cause of death: ICD10	J69.1	Pneumonitis due to oils and essences
40001	Underlying (primary) cause of death: ICD10	J69.8	Pneumonitis due to other solids and liquids
40002	Contributory (secondary) causes of death: ICD10	J69.0	Pneumonitis due to food and vomit
40002	Contributory (secondary) causes of death: ICD10	J69.1	Pneumonitis due to oils and essences
40002	Contributory (secondary) causes of death: ICD10	J69.8	Pneumonitis due to other solids and liquids
42040	GP clinical event records	H470000	Pneumonitis due to inhalation of regurgitated food
42040	GP clinical event records	H470100	Pneumonitis due to inhalation of gastric secretions
42040	GP clinical event records	H470200	Pneumonitis due to inhalation of milk
42040	GP clinical event records	H470211	Milk inhalation pneumonitis
42040	GP clinical event records	H470300	Pneumonitis due to inhalation of vomitus
42040	GP clinical event records	H470311	Vomit inhalation pneumonitis
42040	GP clinical event records	H470312	Aspiration pneumonia due to vomit
42040	GP clinical event records	H470.00	Pneumonitis due to inhalation of food or vomitus
42040	GP clinical event records	H470.11	Aspiration pneumonia
42040	GP clinical event records	H470z00	Pneumonitis due to inhalation of food or vomitus NOS
42040	GP clinical event records	H471000	Lipoid pneumonia (exogenous)
42040	GP clinical event records	H471.00	Pneumonitis due to inhalation of oil or essence
42040	GP clinical event records	H471z00	Pneumonitis due to inhalation of oil or essence NOS
42040	GP clinical event records	H47..00	Pneumonitis due to inhalation of solids or liquids
42040	GP clinical event records	H47..11	Aspiration pneumonitis
42040	GP clinical event records	H47y.00	Pneumonitis due to inhalation of other solid or liquid
42040	GP clinical event records	H47yz00	Pneumonitis due to inhalation of solid or liquid NOS
42040	GP clinical event records	H47z.00	Pneumonitis due to inhalation of solid or liquid NOS
42040	GP clinical event records	Hyu4700	[X]Pneumonitis due to inhalation of other solids and liquids
42040	GP clinical event records	SP13100	Other aspiration pneumonia as a complication of care
42040	GP clinical event records	H47yz	Pneumonitis due to inhalation of solid or liquid NOS