Asthma

Metadata

Name	Asthma (asthma)
Category	Respiratory
Sex
Adult	Yes
UUID	018142ee-ed30-416d-97f1-503f4be316c6
Definition	A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Ontologies

Disease Ontology (DOID)	DOID_2841
GWAS Catalogue	EFO_0000270
MeSH	D001249
SNOMED-CT	195967001
FinnGen	J10_ASTHMA

Key Summary Statistics

Cases from any source

Total	78588
Female (%)	45315 (58%)
Male (%)	33273 (42%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	1435.27 (1411.68,1458.87)
Male	1270.58 (1246.16,1295.0)

Incidence stratified by sex

Female	25.83 (24.4,27.26)
Male	23.56 (22.07,25.04)

Incidence stratified by age

Ages 40-44	23.57 (20.27,26.86)
Ages 45-49	21.49 (18.8,24.18)
Ages 50-54	23.42 (20.83,26.0)
Ages 55-59	23.49 (21.15,25.82)
Ages 60-64	26.33 (24.21,28.44)
Ages 65-69	27.84 (25.35,30.33)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1332 (1297,1367)	1226 (1199,1253)	1201 (1179,1224)
CALIBER	1408 (1398,1418)	1333 (1322,1344)	1362 (1351,1374)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	1290(1209,1376)	1136(1079,1196)	1096(1050,1144)
Low	1267(1185,1353)	1169(1110,1229)	1136(1089,1184)
Medium	1263(1184,1345)	1167(1109,1227)	1120(1073,1169)
High	1325(1251,1403)	1252(1193,1313)	1248(1196,1302)
Most deprived	1465(1393,1541)	1400(1338,1465)	1453(1394,1513)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	1336(1297,1376)	1235(1205,1266)	1200(1175,1225)
Scotland	1199(1104,1299)	1131(1062,1203)	1027(967,1089)
Wales	1509(1373,1654)	1290(1195,1391)	1483(1394,1577)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153513, Events=116

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.85 (1.14, 2.99)	0.0128
BMI	obese	1.9 (1.12, 3.22)	0.0174
BMI	underweight	0 (0, Inf)	0.993
smoking	previous	0.82 (0.53, 1.27)	0.367
smoking	current	1.79 (1.09, 2.95)	0.0215
hypertension	yes	1.55 (1.01, 2.37)	0.0432

Definition

UK Biobank field id	Description	Code	Value
22167	Recent medication for asthma	1	Yes
22127	Doctor diagnosed asthma	1	asthma
6152	Blood clot, DVT, bronchitis, emphysema, asthma, rhinitis, eczema, allergy diagnosed by doctor	8	asthma
20002	Non-cancer illness code, self-reported	1111	asthma
41202	Diagnoses - main ICD10	J45	Asthma
41202	Diagnoses - main ICD10	J46	Status asthmaticus
41204	Diagnoses - secondary ICD10	J45	Asthma
41204	Diagnoses - secondary ICD10	J46	Status asthmaticus
40001	Underlying (primary) cause of death: ICD10	J45	Asthma
40001	Underlying (primary) cause of death: ICD10	J46	Status asthmaticus
40002	Contributory (secondary) causes of death: ICD10	J45	Asthma
40002	Contributory (secondary) causes of death: ICD10	J46	Status asthmaticus
42040	GP clinical event records	14B4.00	H/O: asthma
42040	GP clinical event records	173A.00	Exercise induced asthma
42040	GP clinical event records	173c.00	Occupational asthma
42040	GP clinical event records	173d.00	Work aggravated asthma
42040	GP clinical event records	1780.00	Aspirin induced asthma
42040	GP clinical event records	1O2..00	Asthma confirmed
42040	GP clinical event records	2126200.0	Asthma resolved
42040	GP clinical event records	212G.00	Asthma resolved
42040	GP clinical event records	H312000	Chronic asthmatic bronchitis
42040	GP clinical event records	H330000	Extrinsic asthma without status asthmaticus
42040	GP clinical event records	H330011	Hay fever with asthma
42040	GP clinical event records	H330100	Extrinsic asthma with status asthmaticus
42040	GP clinical event records	H330111	Extrinsic asthma with asthma attack
42040	GP clinical event records	H330.00	Extrinsic (atopic) asthma
42040	GP clinical event records	H330.11	Allergic asthma
42040	GP clinical event records	H330.12	Childhood asthma
42040	GP clinical event records	H330.13	Hay fever with asthma
42040	GP clinical event records	H330.14	Pollen asthma
42040	GP clinical event records	H330z00	Extrinsic asthma NOS
42040	GP clinical event records	H331000	Intrinsic asthma without status asthmaticus
42040	GP clinical event records	H331100	Intrinsic asthma with status asthmaticus
42040	GP clinical event records	H331111	Intrinsic asthma with asthma attack
42040	GP clinical event records	H331.00	Intrinsic asthma
42040	GP clinical event records	H331.11	Late onset asthma
42040	GP clinical event records	H331z00	Intrinsic asthma NOS
42040	GP clinical event records	H332.00	Mixed asthma
42040	GP clinical event records	H333.00	Acute exacerbation of asthma
42040	GP clinical event records	H334.00	Brittle asthma
42040	GP clinical event records	H335.00	Chronic asthma with fixed airflow obstruction
42040	GP clinical event records	H33..00	Asthma
42040	GP clinical event records	H33..11	Bronchial asthma
42040	GP clinical event records	H33z000	Status asthmaticus NOS
42040	GP clinical event records	H33z011	Severe asthma attack
42040	GP clinical event records	H33z100	Asthma attack
42040	GP clinical event records	H33z111	Asthma attack NOS
42040	GP clinical event records	H33z200	Late-onset asthma
42040	GP clinical event records	H33z.00	Asthma unspecified
42040	GP clinical event records	H33z.11	Hyperreactive airways disease
42040	GP clinical event records	H33zz00	Asthma NOS
42040	GP clinical event records	H33zz11	Exercise induced asthma
42040	GP clinical event records	H33zz12	Allergic asthma NEC
42040	GP clinical event records	H33zz13	Allergic bronchitis NEC
42040	GP clinical event records	XE0YU	Intrinsic asthma with status asthmaticus
42040	GP clinical event records	XE0YS	Extrinsic asthma with status asthmaticus
42040	GP clinical event records	XE0YV	Status asthmaticus NOS
42040	GP clinical event records	XE0YW	Asthma attack
42040	GP clinical event records	XaKdk	Work aggravated asthma
42040	GP clinical event records	XaIuG	Asthma confirmed
42040	GP clinical event records	XE0YX	Asthma NOS
42040	GP clinical event records	Xaa7B	Chronic asthma with fixed airflow obstruction
42040	GP clinical event records	X1025	Occupational asthma
42040	GP clinical event records	21262	Asthma resolved
42040	GP clinical event records	Ua1AX	Brittle asthma
42040	GP clinical event records	XE0YR	Extrinsic asthma without status asthmaticus