Metadata

Name Autism and Asperger’s syndrome (autism)
Category Psychiatric
Sex
Adult Yes
UUID efc4925b-7fe7-4005-a200-87a338b643bf
Definition Autism is a developmental disorder characterized by difficulties with social interaction and communication, and by restricted and repetitive behavior.

Ontologies

Disease Ontology (DOID) DOID_1249
GWAS Catalogue EFO_0003758
MeSH D001321
SNOMED-CT 408856003
FinnGen F5_AUTISM

Key Summary Statistics

Cases from any source

Total 430
Female (%) 128 (30%)
Male (%) 302 (70%)

Year first recorded

autism year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced autism cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of autism

Baseline prevalence stratified by sex

Female 2.36 (1.32,3.39)
Male 7.7 (5.67,9.73)

Incidence stratified by sex

Female 0.05 (-0.01,0.11)
Male 0.25 (0.11,0.4)

Incidence stratified by age

Ages 40-44 0.5 (0.06,0.94)
Ages 45-49 0.3 (0.01,0.59)
Ages 50-54 0.13 (-0.05,0.3)
Ages 55-59 0.0 (0.0,0.0)
Ages 60-64 0.08 (-0.03,0.18)
Ages 65-69 0.1 (-0.04,0.24)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB autism prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 6 (4,9) 3 (1,4) 1 (1,2)
CALIBER 12 (11,13) 8 (7,8) 4 (3,4)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 4(1,13) 1(0,5) 2(0,5)
Low 3(0,11) 0(NaN,NaN) 1(0,4)
Medium 3(0,11) 1(0,4) 1(0,3)
High 7(2,15) 3(1,8) 1(0,3)
Most deprived 10(5,18) 8(4,14) 3(1,8)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 4(2,7) 2(1,3) 1(0,2)
Scotland 13(5,28) 8(3,17) 4(1,11)
Wales 13(4,34) 2(0,12) 2(0,9)

Definition

UK Biobank field id Description Code Value
41202 Diagnoses - main ICD10 F84.0 Childhood autism
41202 Diagnoses - main ICD10 F84.1 Atypical autism
41202 Diagnoses - main ICD10 F84.5 Asperger’s syndrome
41204 Diagnoses - secondary ICD10 F84.0 Childhood autism
41204 Diagnoses - secondary ICD10 F84.1 Atypical autism
41204 Diagnoses - secondary ICD10 F84.5 Asperger’s syndrome
40001 Underlying (primary) cause of death: ICD10 F84.0 Childhood autism
40001 Underlying (primary) cause of death: ICD10 F84.1 Atypical autism
40001 Underlying (primary) cause of death: ICD10 F84.5 Asperger’s syndrome
40002 Contributory (secondary) causes of death: ICD10 F84.0 Childhood autism
40002 Contributory (secondary) causes of death: ICD10 F84.1 Atypical autism
40002 Contributory (secondary) causes of death: ICD10 F84.5 Asperger’s syndrome
42040 GP clinical event records E140000 Active infantile autism
42040 GP clinical event records E140100 Residual infantile autism
42040 GP clinical event records E140.00 Infantile autism
42040 GP clinical event records E140.11 Kanner’s syndrome
42040 GP clinical event records E140.12 Autism
42040 GP clinical event records E140.13 Childhood autism
42040 GP clinical event records E140z00 Infantile autism NOS
42040 GP clinical event records Eu84000 [X]Childhood autism
42040 GP clinical event records Eu84011 [X]Autistic disorder
42040 GP clinical event records Eu84012 [X]Infantile autism
42040 GP clinical event records Eu84014 [X]Kanner’s syndrome
42040 GP clinical event records Eu84100 [X]Atypical autism
42040 GP clinical event records Eu84112 [X]Mental retardation with autistic features
42040 GP clinical event records Eu84500 [X]Asperger’s syndrome
42040 GP clinical event records Eu84511 [X]Autistic psychopathy
42040 GP clinical event records Eu84z11 [X]Autistic spectrum disorder
20544 Mental health problems ever diagnosed by a professional 14 Autism Aspergers or autistic spectrum disorder