| Name |
Autoimmune liver disease (autoimm_liver) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
09f3e096-cdcd-4fe6-aa54-b16f1278643a |
| Definition |
An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body’s immune system attacking the liver cells. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
899 |
| Female (%) |
724 (81%) |
| Male (%) |
175 (19%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
14.97 (12.37,17.57) |
| Male |
4.9 (3.28,6.52) |
Incidence stratified by sex
| Female |
1.69 (1.35,2.03) |
| Male |
0.32 (0.16,0.48) |
Incidence stratified by age
| Ages 40-44 |
0.5 (0.06,0.94) |
| Ages 45-49 |
1.04 (0.49,1.58) |
| Ages 50-54 |
0.82 (0.38,1.27) |
| Ages 55-59 |
1.3 (0.79,1.81) |
| Ages 60-64 |
1.15 (0.74,1.57) |
| Ages 65-69 |
1.21 (0.72,1.69) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
8 (5,11) |
14 (11,17) |
20 (18,23) |
| CALIBER |
5 (5,6) |
10 (9,11) |
15 (14,16) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
8(3,18) |
15(9,23) |
15(10,21) |
| Low |
9(4,19) |
9(5,16) |
21(15,28) |
| Medium |
11(5,21) |
11(6,18) |
19(14,27) |
| High |
3(1,9) |
16(10,24) |
25(18,33) |
| Most deprived |
8(3,15) |
18(12,26) |
23(16,31) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
6(4,9) |
12(10,16) |
21(18,25) |
| Scotland |
15(6,30) |
20(12,32) |
14(8,22) |
| Wales |
9(2,26) |
16(7,31) |
23(13,37) |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1506 |
primary biliary cirrhosis |
| 41202 |
Diagnoses - main ICD10 |
K74.3 |
Primary biliary cirrhosis |
| 41202 |
Diagnoses - main ICD10 |
K75.4 |
Autoimmune hepatitis |
| 41204 |
Diagnoses - secondary ICD10 |
K74.3 |
Primary biliary cirrhosis |
| 41204 |
Diagnoses - secondary ICD10 |
K75.4 |
Autoimmune hepatitis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K74.3 |
Primary biliary cirrhosis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K75.4 |
Autoimmune hepatitis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K74.3 |
Primary biliary cirrhosis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K75.4 |
Autoimmune hepatitis |
| 42040 |
GP clinical event records |
J614111 |
Autoimmune chronic active hepatitis |
| 42040 |
GP clinical event records |
J616000 |
Primary biliary cirrhosis |
| 42040 |
GP clinical event records |
J63B.00 |
Autoimmune hepatitis |
| 42040 |
GP clinical event records |
J661700 |
Primary sclerosing cholangitis |
| 42040 |
GP clinical event records |
XaJTk |
Autoimmune hepatitis |