Disorders of autonomic nervous system

Metadata

Name	Disorders of autonomic nervous system (autonomic_neuro)
Category	Neurological
Sex
Adult	Yes
UUID	aa0b8a93-a1e4-4311-82e7-660d690c80a6
Definition	Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.

Ontologies

Disease Ontology (DOID)	DOID_11504
GWAS Catalogue	EFO_0003100
MeSH	D001342
SNOMED-CT	277879009
FinnGen	G6_AUTONOM

Key Summary Statistics

Cases from any source

Total	1454
Female (%)	747 (51%)
Male (%)	707 (49%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	17.68 (14.85,20.51)
Male	16.24 (13.29,19.19)

Incidence stratified by sex

Female	1.88 (1.53,2.24)
Male	1.77 (1.39,2.15)

Incidence stratified by age

Ages 40-44	1.21 (0.52,1.89)
Ages 45-49	1.04 (0.49,1.58)
Ages 50-54	1.65 (1.02,2.28)
Ages 55-59	2.13 (1.48,2.79)
Ages 60-64	2.08 (1.52,2.63)
Ages 65-69	2.21 (1.56,2.87)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	15 (11,19)	27 (24,32)	32 (28,36)
CALIBER	24 (22,25)	34 (32,35)	46 (44,48)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	11(5,21)	15(9,23)	28(21,37)
Low	11(5,21)	23(15,32)	29(22,37)
Medium	13(6,24)	29(21,40)	29(22,38)
High	16(9,26)	22(15,32)	31(23,41)
Most deprived	21(13,32)	47(36,60)	43(33,55)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	15(11,20)	28(24,33)	31(27,36)
Scotland	12(5,25)	26(17,39)	30(20,42)
Wales	20(7,44)	24(13,41)	40(27,58)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153420, Events=132

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.98 (0.66, 1.47)	0.928
BMI	obese	1.08 (0.69, 1.7)	0.735
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	1.16 (0.78, 1.73)	0.462
smoking	current	2.27 (1.45, 3.57)	0.000355
hypertension	yes	1.19 (0.76, 1.85)	0.449

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	G90	Disorders of autonomic nervous system
41202	Diagnoses - main ICD10	G99.0	Autonomic neuropathy in endocrine and metabolic diseases
41202	Diagnoses - main ICD10	G99.1	Other disorders of autonomic nervous system in other diseases classified elsewhere
41202	Diagnoses - main ICD10	M89.0	Algoneurodystrophy
41204	Diagnoses - secondary ICD10	G90	Disorders of autonomic nervous system
41204	Diagnoses - secondary ICD10	G99.0	Autonomic neuropathy in endocrine and metabolic diseases
41204	Diagnoses - secondary ICD10	G99.1	Other disorders of autonomic nervous system in other diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M89.0	Algoneurodystrophy
40001	Underlying (primary) cause of death: ICD10	G90	Disorders of autonomic nervous system
40001	Underlying (primary) cause of death: ICD10	G99.0	Autonomic neuropathy in endocrine and metabolic diseases
40001	Underlying (primary) cause of death: ICD10	G99.1	Other disorders of autonomic nervous system in other diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	M89.0	Algoneurodystrophy
40002	Contributory (secondary) causes of death: ICD10	G90	Disorders of autonomic nervous system
40002	Contributory (secondary) causes of death: ICD10	G99.0	Autonomic neuropathy in endocrine and metabolic diseases
40002	Contributory (secondary) causes of death: ICD10	G99.1	Other disorders of autonomic nervous system in other diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M89.0	Algoneurodystrophy
42040	GP clinical event records	2BE3.00	O/E - Horner’s syndrome
42040	GP clinical event records	F170000	Carotid sinus syndrome
42040	GP clinical event records	F170100	Cervical sympathetic paralysis
42040	GP clinical event records	F170.00	Idiopathic peripheral autonomic neuropathy
42040	GP clinical event records	F170z00	Idiopathic peripheral autonomic neuropathy NOS
42040	GP clinical event records	F171000	Autonomic neuropathy due to amyloid
42040	GP clinical event records	F171100	Autonomic neuropathy due to diabetes
42040	GP clinical event records	F171.00	Peripheral autonomic neuropathy disease EC
42040	GP clinical event records	F171z00	Peripheral autonomic neuropathy due to disease NOS
42040	GP clinical event records	F172.00	[X] Horners syndrome
42040	GP clinical event records	F173.00	Shoulder-hand syndrome
42040	GP clinical event records	F175.00	Autonomic dysreflexia
42040	GP clinical event records	F17..00	Autonomic nervous system disorders
42040	GP clinical event records	F17z.00	Autonomic nervous system disorder NOS
42040	GP clinical event records	F17z.11	Horner’s syndrome
42040	GP clinical event records	F17z.12	Autonomic failure
42040	GP clinical event records	F347.00	Complex regional pain syndrome type II
42040	GP clinical event records	F369.00	Complex regional pain syndrome
42040	GP clinical event records	FyuAC00	[X]Autonomic neuropathy/endocrine+metabolic diseases CE
42040	GP clinical event records	FyuAD00	[X]Other disordrs/autonomic nervous system/other diseases CE
42040	GP clinical event records	N337100	Sudek’s atrophy
42040	GP clinical event records	N337111	Reflex sympathetic dystrophy
42040	GP clinical event records	N337200	Algodystrophy of hand
42040	GP clinical event records	N337300	Algodystrophy of knee
42040	GP clinical event records	N337400	Algodystrophy of foot
42040	GP clinical event records	N337.00	Algoneurodystrophy
42040	GP clinical event records	N337.11	Algodystrophy
42040	GP clinical event records	N337.12	Reflex sympathetic dystrophy
42040	GP clinical event records	N337z00	Algoneurodystrophy NOS
42040	GP clinical event records	N33C.00	Complex regional pain syndrome type I
42040	GP clinical event records	P2x2.00	Familial dysautonomia
42040	GP clinical event records	P2x5.00	Riley - Day syndrome
42040	GP clinical event records	Xa0y5	Complex regional pain syndrome
42040	GP clinical event records	F344.	Complex regional pain syndrome type II
42040	GP clinical event records	X00CM	Shoulder-hand syndrome
42040	GP clinical event records	N337.	Complex regional pain syndrome type I
42040	GP clinical event records	P2x5.	Familial dysautonomia
42040	GP clinical event records	XE15R	Autonomic nervous system disorder NOS
42040	GP clinical event records	XaYP0	Autonomic dysreflexia