| Name |
Atrioventricular block, first degree (av_block_1) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
8ee1bbcd-449b-47f3-b3c3-357c8516bbb0 |
| Definition |
An atrioventricular block that is characterized by prolonged PR interval on electrocardiogram caused by delayed conduction from atria to ventricles through the atrioventricular node. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
4000 |
| Female (%) |
1101 (28%) |
| Male (%) |
2899 (72%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
3.06 (1.89,4.24) |
| Male |
10.92 (8.5,13.34) |
Incidence stratified by sex
| Female |
1.9 (1.54,2.26) |
| Male |
6.75 (6.01,7.49) |
Incidence stratified by age
| Ages 40-44 |
0.9 (0.31,1.5) |
| Ages 45-49 |
1.78 (1.07,2.49) |
| Ages 50-54 |
1.71 (1.07,2.36) |
| Ages 55-59 |
2.7 (1.97,3.44) |
| Ages 60-64 |
5.54 (4.63,6.44) |
| Ages 65-69 |
8.66 (7.37,9.96) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
9 (6,13) |
21 (17,24) |
48 (43,53) |
| CALIBER |
5 (5,6) |
13 (12,14) |
36 (34,38) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
12(5,24) |
9(5,17) |
37(29,46) |
| Low |
5(1,14) |
21(14,31) |
50(40,61) |
| Medium |
8(3,18) |
30(21,41) |
38(29,48) |
| High |
10(5,20) |
16(10,25) |
54(44,67) |
| Most deprived |
10(5,18) |
27(19,37) |
65(53,79) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
10(7,14) |
22(18,27) |
52(46,57) |
| Scotland |
6(1,17) |
18(10,30) |
35(25,49) |
| Wales |
7(1,27) |
10(3,23) |
29(18,45) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154060, Events=218
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.89 (0.65, 1.23) |
0.488 |
| BMI |
obese |
1.16 (0.82, 1.63) |
0.404 |
| BMI |
underweight |
0 (0, Inf) |
0.989 |
| smoking |
previous |
1.75 (1.31, 2.35) |
0.000182 |
| smoking |
current |
2.37 (1.58, 3.55) |
3.07e-05 |
| hypertension |
yes |
1 (0.74, 1.36) |
0.997 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
I44.0 |
Atrioventricular block, first degree |
| 41204 |
Diagnoses - secondary ICD10 |
I44.0 |
Atrioventricular block, first degree |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I44.0 |
Atrioventricular block, first degree |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I44.0 |
Atrioventricular block, first degree |
| 42040 |
GP clinical event records |
3294 |
ECG:partial A-V block-long P-R |
| 42040 |
GP clinical event records |
32I3.00 |
ECG: P-R interval prolonged |
| 42040 |
GP clinical event records |
G561100 |
First degree atrioventricular block |
| 42040 |
GP clinical event records |
G561111 |
Prolonged P-R interval |
| 42040 |
GP clinical event records |
XE2QF |
First degree atrioventricular block |