| Name |
Atrioventricular block, second degree (av_block_2) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
2d9dfc35-e6ad-4321-94e0-99da8fd9bae3 |
| Definition |
An atrioventricular block that is characterized by progressive prolongation of the PR interval on consecutive beats followed by a blocked P wave on electrocardiogram or intermittently non-conducted P waves not preceded by PR changes on electrocardiogram caused by a conduction block between the atria and the ventricles through the atrioventricular node. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1452 |
| Female (%) |
475 (33%) |
| Male (%) |
977 (67%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
2.12 (1.14,3.1) |
| Male |
5.18 (3.51,6.85) |
Incidence stratified by sex
| Female |
0.72 (0.5,0.94) |
| Male |
2.23 (1.81,2.66) |
Incidence stratified by age
| Ages 40-44 |
0.5 (0.06,0.94) |
| Ages 45-49 |
0.82 (0.33,1.3) |
| Ages 50-54 |
0.51 (0.16,0.86) |
| Ages 55-59 |
1.14 (0.67,1.62) |
| Ages 60-64 |
1.61 (1.12,2.1) |
| Ages 65-69 |
2.96 (2.21,3.72) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
5 (3,8) |
8 (6,11) |
17 (15,20) |
| CALIBER |
3 (2,3) |
6 (5,7) |
17 (16,18) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
4(1,13) |
6(2,12) |
17(12,24) |
| Low |
8(2,18) |
7(3,14) |
15(10,22) |
| Medium |
0(NaN,NaN) |
11(6,19) |
22(15,29) |
| High |
6(2,13) |
7(3,14) |
15(10,22) |
| Most deprived |
7(3,14) |
9(5,16) |
18(12,26) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
5(3,8) |
9(7,12) |
18(15,21) |
| Scotland |
6(1,17) |
5(1,12) |
16(9,25) |
| Wales |
0(NaN,NaN) |
6(1,18) |
17(8,30) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154060, Events=218
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.89 (0.65, 1.23) |
0.488 |
| BMI |
obese |
1.16 (0.82, 1.63) |
0.404 |
| BMI |
underweight |
0 (0, Inf) |
0.989 |
| smoking |
previous |
1.75 (1.31, 2.35) |
0.000182 |
| smoking |
current |
2.37 (1.58, 3.55) |
3.07e-05 |
| hypertension |
yes |
1 (0.74, 1.36) |
0.997 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
I44.1 |
Atrioventricular block, second degree |
| 41204 |
Diagnoses - secondary ICD10 |
I44.1 |
Atrioventricular block, second degree |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I44.1 |
Atrioventricular block, second degree |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I44.1 |
Atrioventricular block, second degree |
| 42040 |
GP clinical event records |
3295.00 |
ECG: partial A-V block - 2:1 |
| 42040 |
GP clinical event records |
3296.00 |
ECG: partial A-V block - 3:1 |
| 42040 |
GP clinical event records |
3297.00 |
ECG: Wenckebach phenomenon |
| 42040 |
GP clinical event records |
3297.11 |
Electrocardiogram: Mobitz type 1 second degree AV block |
| 42040 |
GP clinical event records |
329H.00 |
Electrocardiogram: Mobitz type 2 second degree AV block |
| 42040 |
GP clinical event records |
G561200 |
Mobitz type II atrioventricular block |
| 42040 |
GP clinical event records |
G561300 |
Mobitz type I (Wenckebach) atrioventricular block |
| 42040 |
GP clinical event records |
G561311 |
Mobitz type 1 second degree atrioventricular block |
| 42040 |
GP clinical event records |
G561400 |
Second degree atrioventricular block |
| 42040 |
GP clinical event records |
XaXGh |
Electrocardiogram: Mobitz type 2 second degree atrioventricular block |
| 42040 |
GP clinical event records |
X202a |
Second degree atrioventricular block |