| Name |
Atrioventricular block, complete (av_block_3) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
ca8012a0-8cab-47ee-bc87-8717817d32f8 |
| Definition |
An atrioventricular block that is characterized by bradycardia, hypotension, hemodynamic instability and complete dissociation between P waves and QRS complexes on electrocardiogram caused when conduction fails to propagate from atria to ventricles. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1831 |
| Female (%) |
531 (29%) |
| Male (%) |
1300 (71%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
3.3 (2.08,4.52) |
| Male |
6.86 (4.94,8.78) |
Incidence stratified by sex
| Female |
0.77 (0.54,1.0) |
| Male |
2.17 (1.75,2.59) |
Incidence stratified by age
| Ages 40-44 |
0.4 (0.01,0.8) |
| Ages 45-49 |
0.37 (0.05,0.7) |
| Ages 50-54 |
0.44 (0.11,0.77) |
| Ages 55-59 |
1.14 (0.67,1.62) |
| Ages 60-64 |
1.31 (0.87,1.74) |
| Ages 65-69 |
3.77 (2.92,4.62) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
4 (2,7) |
6 (4,8) |
23 (20,27) |
| CALIBER |
3 (2,3) |
7 (7,8) |
23 (22,25) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
3(0,9) |
5(2,11) |
20(15,28) |
| Low |
0(NaN,NaN) |
5(2,11) |
24(18,32) |
| Medium |
5(1,13) |
6(3,13) |
26(19,35) |
| High |
7(2,15) |
5(2,11) |
22(15,30) |
| Most deprived |
5(2,11) |
7(3,13) |
24(16,33) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
4(2,6) |
6(4,9) |
23(20,27) |
| Scotland |
7(2,18) |
0(NaN,NaN) |
13(7,22) |
| Wales |
3(0,17) |
12(4,26) |
39(26,57) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153996, Events=147
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.93 (0.63, 1.37) |
0.695 |
| BMI |
obese |
1 (0.64, 1.55) |
0.987 |
| BMI |
underweight |
0 (0, Inf) |
0.994 |
| smoking |
previous |
1.24 (0.87, 1.76) |
0.231 |
| smoking |
current |
1.53 (0.9, 2.59) |
0.116 |
| hypertension |
yes |
1.65 (1.18, 2.3) |
0.00322 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
I44.2 |
Atrioventricular block, complete |
| 41204 |
Diagnoses - secondary ICD10 |
I44.2 |
Atrioventricular block, complete |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I44.2 |
Atrioventricular block, complete |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I44.2 |
Atrioventricular block, complete |
| 42040 |
GP clinical event records |
3293.00 |
ECG:complete sinu-atrial block |
| 42040 |
GP clinical event records |
3298.00 |
ECG: complete A-V block |
| 42040 |
GP clinical event records |
G560.00 |
Complete atrioventricular block |
| 42040 |
GP clinical event records |
G560.11 |
Third degree atrioventricular block |