Metadata

Name Bipolar affective disorder and mania (BAD)
Category Psychiatric
Sex
Adult Yes
UUID aca308c8-7c3c-43db-aa66-2194b46fb915
Definition Bipolar disorder causes extreme mood swings that include emotional highs (mania or hypomania) and lows (depression).

Ontologies

Disease Ontology (DOID) DOID_3312
GWAS Catalogue EFO_0000289
MeSH D001714
SNOMED-CT 13746004
FinnGen F5_BIPO

Key Summary Statistics

Cases from any source

Total 4159
Female (%) 2260 (54%)
Male (%) 1899 (46%)

Year first recorded

BAD year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced BAD cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of BAD

Baseline prevalence stratified by sex

Female 68.6 (63.05,74.16)
Male 76.44 (70.05,82.82)

Incidence stratified by sex

Female 1.66 (1.33,2.0)
Male 1.46 (1.12,1.81)

Incidence stratified by age

Ages 40-44 2.23 (1.3,3.16)
Ages 45-49 2.02 (1.26,2.78)
Ages 50-54 1.85 (1.18,2.52)
Ages 55-59 0.78 (0.39,1.18)
Ages 60-64 1.74 (1.23,2.25)
Ages 65-69 1.26 (0.77,1.76)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB BAD prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 51 (44,58) 49 (44,54) 51 (47,56)
CALIBER 66 (64,68) 62 (60,64) 59 (56,61)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 31(19,47) 30(22,41) 37(29,46)
Low 21(12,35) 34(25,45) 39(30,48)
Medium 33(22,49) 40(30,52) 47(38,58)
High 50(36,67) 41(31,54) 59(48,71)
Most deprived 97(79,118) 98(82,116) 81(67,96)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 50(42,58) 50(44,57) 49(44,54)
Scotland 51(33,75) 47(34,63) 65(51,83)
Wales 64(38,100) 35(21,55) 57(41,78)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=152960, Events=163

Factor Level Hazard Ratio P value
BMI overweight 1.3 (0.88, 1.92) 0.185
BMI obese 1.75 (1.16, 2.63) 0.00738
BMI underweight 0 (0, Inf) 0.991
smoking previous 1.02 (0.7, 1.49) 0.904
smoking current 3.45 (2.37, 5.02) 8.66e-11
hypertension yes 1.36 (0.94, 1.95) 0.101

Genetic correlation

Genetic correlation (rg) P value
0.84 9.99e-07

Published study: Stahl (2019)

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1291 mania/bipolar disorder/manic depression
41202 Diagnoses - main ICD10 F30 Manic episode
41202 Diagnoses - main ICD10 F31 Bipolar affective disorder
41204 Diagnoses - secondary ICD10 F30 Manic episode
41204 Diagnoses - secondary ICD10 F31 Bipolar affective disorder
40001 Underlying (primary) cause of death: ICD10 F30 Manic episode
40001 Underlying (primary) cause of death: ICD10 F31 Bipolar affective disorder
40002 Contributory (secondary) causes of death: ICD10 F30 Manic episode
40002 Contributory (secondary) causes of death: ICD10 F31 Bipolar affective disorder
42040 GP clinical event records 146D.00 H/O: manic depressive disorder
42040 GP clinical event records 1S42.00 Manic mood
42040 GP clinical event records 212V.00 Bipolar affective disorder resolved
42040 GP clinical event records E110000 Single manic episode, unspecified
42040 GP clinical event records E110100 Single manic episode, mild
42040 GP clinical event records E110200 Single manic episode, moderate
42040 GP clinical event records E110300 Single manic episode, severe without mention of psychosis
42040 GP clinical event records E110400 Single manic episode, severe, with psychosis
42040 GP clinical event records E110500 Single manic episode in partial or unspecified remission
42040 GP clinical event records E110600 Single manic episode in full remission
42040 GP clinical event records E110.00 Manic disorder, single episode
42040 GP clinical event records E110.11 Hypomanic psychoses
42040 GP clinical event records E110z00 Manic disorder, single episode NOS
42040 GP clinical event records E111000 Recurrent manic episodes, unspecified
42040 GP clinical event records E111100 Recurrent manic episodes, mild
42040 GP clinical event records E111200 Recurrent manic episodes, moderate
42040 GP clinical event records E111300 Recurrent manic episodes, severe without mention psychosis
42040 GP clinical event records E111400 Recurrent manic episodes, severe, with psychosis
42040 GP clinical event records E111500 Recurrent manic episodes, partial or unspecified remission
42040 GP clinical event records E111600 Recurrent manic episodes, in full remission
42040 GP clinical event records E111.00 Recurrent manic episodes
42040 GP clinical event records E111z00 Recurrent manic episode NOS
42040 GP clinical event records E114000 Bipolar affective disorder, currently manic, unspecified
42040 GP clinical event records E114100 Bipolar affective disorder, currently manic, mild
42040 GP clinical event records E114200 Bipolar affective disorder, currently manic, moderate
42040 GP clinical event records E114300 Bipolar affect disord, currently manic, severe, no psychosis
42040 GP clinical event records E114400 Bipolar affect disord, currently manic,severe with psychosis
42040 GP clinical event records E114500 Bipolar affect disord,currently manic, part/unspec remission
42040 GP clinical event records E114600 Bipolar affective disorder, currently manic, full remission
42040 GP clinical event records E114.00 Bipolar affective disorder, currently manic
42040 GP clinical event records E114.11 Manic-depressive - now manic
42040 GP clinical event records E114z00 Bipolar affective disorder, currently manic, NOS
42040 GP clinical event records E115000 Bipolar affective disorder, currently depressed, unspecified
42040 GP clinical event records E115100 Bipolar affective disorder, currently depressed, mild
42040 GP clinical event records E115200 Bipolar affective disorder, currently depressed, moderate
42040 GP clinical event records E115300 Bipolar affect disord, now depressed, severe, no psychosis
42040 GP clinical event records E115400 Bipolar affect disord, now depressed, severe with psychosis
42040 GP clinical event records E115500 Bipolar affect disord, now depressed, part/unspec remission
42040 GP clinical event records E115600 Bipolar affective disorder, now depressed, in full remission
42040 GP clinical event records E115.00 Bipolar affective disorder, currently depressed
42040 GP clinical event records E115.11 Manic-depressive - now depressed
42040 GP clinical event records E115z00 Bipolar affective disorder, currently depressed, NOS
42040 GP clinical event records E116000 Mixed bipolar affective disorder, unspecified
42040 GP clinical event records E116100 Mixed bipolar affective disorder, mild
42040 GP clinical event records E116200 Mixed bipolar affective disorder, moderate
42040 GP clinical event records E116300 Mixed bipolar affective disorder, severe, without psychosis
42040 GP clinical event records E116400 Mixed bipolar affective disorder, severe, with psychosis
42040 GP clinical event records E116500 Mixed bipolar affective disorder, partial/unspec remission
42040 GP clinical event records E116600 Mixed bipolar affective disorder, in full remission
42040 GP clinical event records E116.00 Mixed bipolar affective disorder
42040 GP clinical event records E116z00 Mixed bipolar affective disorder, NOS
42040 GP clinical event records E117000 Unspecified bipolar affective disorder, unspecified
42040 GP clinical event records E117100 Unspecified bipolar affective disorder, mild
42040 GP clinical event records E117200 Unspecified bipolar affective disorder, moderate
42040 GP clinical event records E117300 Unspecified bipolar affective disorder, severe, no psychosis
42040 GP clinical event records E117400 Unspecified bipolar affective disorder,severe with psychosis
42040 GP clinical event records E117500 Unspecified bipolar affect disord, partial/unspec remission
42040 GP clinical event records E117600 Unspecified bipolar affective disorder, in full remission
42040 GP clinical event records E117.00 Unspecified bipolar affective disorder
42040 GP clinical event records E117z00 Unspecified bipolar affective disorder, NOS
42040 GP clinical event records E11..11 Bipolar psychoses
42040 GP clinical event records E11..13 Manic psychoses
42040 GP clinical event records E11y000 Unspecified manic-depressive psychoses
42040 GP clinical event records E11y100 Atypical manic disorder
42040 GP clinical event records E11y300 Other mixed manic-depressive psychoses
42040 GP clinical event records E11y.00 Other and unspecified manic-depressive psychoses
42040 GP clinical event records E11yz00 Other and unspecified manic-depressive psychoses NOS
42040 GP clinical event records Eu30000 [X]Hypomania
42040 GP clinical event records Eu30100 [X]Mania without psychotic symptoms
42040 GP clinical event records Eu30200 [X]Mania with psychotic symptoms
42040 GP clinical event records Eu30211 [X]Mania with mood-congruent psychotic symptoms
42040 GP clinical event records Eu30212 [X]Mania with mood-incongruent psychotic symptoms
42040 GP clinical event records Eu30.00 [X]Manic episode
42040 GP clinical event records Eu30.11 [X]Bipolar disorder, single manic episode
42040 GP clinical event records Eu30y00 [X]Other manic episodes
42040 GP clinical event records Eu30z00 [X]Manic episode, unspecified
42040 GP clinical event records Eu30z11 [X]Mania NOS
42040 GP clinical event records Eu31000 [X]Bipolar affective disorder, current episode hypomanic
42040 GP clinical event records Eu31100 [X]Bipolar affect disorder cur epi manic wout psychotic symp
42040 GP clinical event records Eu31200 [X]Bipolar affect disorder cur epi manic with psychotic symp
42040 GP clinical event records Eu31300 [X]Bipolar affect disorder cur epi mild or moderate depressn
42040 GP clinical event records Eu31400 [X]Bipol aff disord, curr epis sev depress, no psychot symp
42040 GP clinical event records Eu31500 [X]Bipolar affect dis cur epi severe depres with psyc symp
42040 GP clinical event records Eu31600 [X]Bipolar affective disorder, current episode mixed
42040 GP clinical event records Eu31700 [X]Bipolar affective disorder, currently in remission
42040 GP clinical event records Eu31800 [X]Bipolar affective disorder type I
42040 GP clinical event records Eu31900 [X]Bipolar affective disorder type II
42040 GP clinical event records Eu31911 [X]Bipolar II disorder
42040 GP clinical event records Eu31.00 [X]Bipolar affective disorder
42040 GP clinical event records Eu31.11 [X]Manic-depressive illness
42040 GP clinical event records Eu31.12 [X]Manic-depressive psychosis
42040 GP clinical event records Eu31.13 [X]Manic-depressive reaction
42040 GP clinical event records Eu31y00 [X]Other bipolar affective disorders
42040 GP clinical event records Eu31y11 [X]Bipolar II disorder
42040 GP clinical event records Eu31y12 [X]Recurrent manic episodes
42040 GP clinical event records Eu31z00 [X]Bipolar affective disorder, unspecified
42040 GP clinical event records Eu33213 [X]Manic-depress psychosis,depressd,no psychotic symptoms
42040 GP clinical event records Eu33312 [X]Manic-depress psychosis,depressed type+psychotic symptoms
42040 GP clinical event records ZRby100 Profile of mood states, bipolar
42040 GP clinical event records ZV11111 [V]Personal history of manic-depressive psychosis
42040 GP clinical event records ZV11112 [V]Personal history of manic-depressive psychosis
42040 GP clinical event records XaIx7 H/O: manic depressive disorder
42040 GP clinical event records XE1ZV [X]Mania with psychotic symptoms
42040 GP clinical event records XE1ZW [X]Manic episode, unspecified
42040 GP clinical event records XE1ZW [X]Manic episode, unspecified
42040 GP clinical event records XE1Zd [X]Recurrent depressive disorder, current episode severe without psychotic symptoms
42040 GP clinical event records XE1Zd [X]Recurrent depressive disorder, current episode severe without psychotic symptoms
42040 GP clinical event records XE1Xz Manic disorder, single episode
42040 GP clinical event records XE1ZX [X]Other bipolar affective disorders
42040 GP clinical event records XaMwc Bipolar affective disorder resolved
42040 GP clinical event records XE1Ze [X]Recurrent depressive disorder, current episode severe with psychotic symptoms
42040 GP clinical event records Xa3WO Manic mood
20122 Type of bipolar episode 1 Bipolar Type I (Mania)
20122 Type of bipolar episode 2 Bipolar Type II (Hypomania)
20126 Bipolar and major depression status 1 Bipolar I Disorder
20126 Bipolar and major depression status 2 Bipolar II Disorder