| Name |
Barrett’s oesophagus (barretts) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
f78dc26c-95cf-4ce7-8023-22daff4e24e1 |
| Definition |
Barrett’s Oesophagus is the term used for a pre-cancerous condition where the normal cells lining the oesophagus, also known as the gullet or food pipe, have been replaced with abnormal cells. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
8133 |
| Female (%) |
3115 (38%) |
| Male (%) |
5018 (62%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
37.48 (33.37,41.6) |
| Male |
75.46 (69.11,81.8) |
Incidence stratified by sex
| Female |
6.43 (5.77,7.09) |
| Male |
12.08 (11.09,13.07) |
Incidence stratified by age
| Ages 40-44 |
3.32 (2.19,4.46) |
| Ages 45-49 |
4.69 (3.53,5.85) |
| Ages 50-54 |
6.49 (5.23,7.75) |
| Ages 55-59 |
9.26 (7.9,10.63) |
| Ages 60-64 |
11.98 (10.64,13.31) |
| Ages 65-69 |
12.61 (11.04,14.18) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
37 (31,44) |
83 (76,91) |
139 (132,147) |
| CALIBER |
30 (29,31) |
68 (66,71) |
122 (119,126) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
20(11,33) |
89(73,108) |
124(108,140) |
| Low |
26(15,41) |
68(54,84) |
129(113,146) |
| Medium |
43(29,61) |
81(66,98) |
141(124,159) |
| High |
37(25,52) |
82(67,99) |
140(122,159) |
| Most deprived |
52(39,68) |
95(79,114) |
169(150,191) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
36(30,43) |
88(80,96) |
145(136,154) |
| Scotland |
48(30,72) |
81(63,103) |
118(97,140) |
| Wales |
29(12,57) |
40(24,62) |
114(90,143) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154022, Events=131
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.27 (0.78, 2.07) |
0.333 |
| BMI |
obese |
2.62 (1.63, 4.22) |
6.84e-05 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.3 (0.9, 1.9) |
0.166 |
| smoking |
current |
1.71 (0.99, 2.95) |
0.0544 |
| hypertension |
yes |
1.97 (1.38, 2.82) |
0.000171 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1139 |
oesophagitis/barretts oesophagus |
| 41202 |
Diagnoses - main ICD10 |
K22.7 |
Barrett’s oesophagus |
| 41204 |
Diagnoses - secondary ICD10 |
K22.7 |
Barrett’s oesophagus |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K22.7 |
Barrett’s oesophagus |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K22.7 |
Barrett’s oesophagus |
| 42040 |
GP clinical event records |
J101611 |
Barrett’s oesophagus |
| 42040 |
GP clinical event records |
J102500 |
Barrett’s ulcer of oesophagus |
| 42040 |
GP clinical event records |
J10y600 |
Barrett’s oesophagus |
| 42040 |
GP clinical event records |
Xa9Bz |
Barrett’s oesophagus |