Metadata

Name Benign neoplasm of brain and other parts of central nervous system (benign_brain)
Category Benign neoplasm or Carcinoma in situ
Sex
Adult Yes
UUID 28dce8a8-8e09-48fa-ab55-106d83747f62
Definition A brain or nervous system benign neoplasm that is characterized by lack of malignancy.

Ontologies

Disease Ontology (DOID) DOID_0060090
GWAS Catalogue MONDO_0000648
SNOMED-CT 92048008
FinnGen CD2_BENIGN_BRAIN_CNS

Key Summary Statistics

Cases from any source

Total 3163
Female (%) 1957 (62%)
Male (%) 1206 (38%)

Year first recorded

benign_brain year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced benign_brain cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of benign_brain

Baseline prevalence stratified by sex

Female 38.66 (34.49,42.84)
Male 26.74 (22.95,30.53)

Incidence stratified by sex

Female 3.25 (2.78,3.72)
Male 2.66 (2.19,3.12)

Incidence stratified by age

Ages 40-44 1.71 (0.9,2.53)
Ages 45-49 2.31 (1.49,3.12)
Ages 50-54 1.91 (1.22,2.59)
Ages 55-59 3.39 (2.57,4.22)
Ages 60-64 2.93 (2.27,3.59)
Ages 65-69 4.59 (3.65,5.53)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB benign_brain prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 34 (28,40) 41 (36,46) 53 (48,58)
CALIBER 22 (21,23) 35 (33,36) 46 (44,48)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 24(14,38) 38(28,50) 49(40,60)
Low 31(19,47) 38(28,50) 57(47,68)
Medium 34(22,50) 49(38,62) 56(46,67)
High 39(27,54) 39(29,51) 52(42,64)
Most deprived 37(27,51) 40(30,52) 50(39,62)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 32(27,39) 40(35,46) 50(45,56)
Scotland 48(31,72) 48(35,65) 67(52,84)
Wales 22(9,46) 34(20,53) 60(43,81)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor Level Hazard Ratio P value
BMI overweight 0.89 (0.68, 1.17) 0.406
BMI obese 1.13 (0.84, 1.51) 0.416
BMI underweight 0 (0, Inf) 0.987
smoking previous 0.95 (0.75, 1.22) 0.699
smoking current 1.05 (0.72, 1.55) 0.789
hypertension yes 1.12 (0.87, 1.45) 0.386

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1659 meningioma / benign meningeal tumour
20002 Non-cancer illness code, self-reported 1238 pituitary adenoma/tumour
41202 Diagnoses - main ICD10 D32 Benign neoplasm of meninges
41202 Diagnoses - main ICD10 D33 Benign neoplasm of brain and other parts of central nervous system
41202 Diagnoses - main ICD10 D35.2 Benign neoplasm: Pituitary gland
41202 Diagnoses - main ICD10 D35.3 Benign neoplasm: Craniopharyngeal duct
41202 Diagnoses - main ICD10 D35.4 Benign neoplasm: Pineal gland
41202 Diagnoses - main ICD10 D35.5 Benign neoplasm: Carotid body
41202 Diagnoses - main ICD10 D35.6 Benign neoplasm: Aortic body and other paraganglia
41204 Diagnoses - secondary ICD10 D32 Benign neoplasm of meninges
41204 Diagnoses - secondary ICD10 D33 Benign neoplasm of brain and other parts of central nervous system
41204 Diagnoses - secondary ICD10 D35.2 Benign neoplasm: Pituitary gland
41204 Diagnoses - secondary ICD10 D35.3 Benign neoplasm: Craniopharyngeal duct
41204 Diagnoses - secondary ICD10 D35.4 Benign neoplasm: Pineal gland
41204 Diagnoses - secondary ICD10 D35.5 Benign neoplasm: Carotid body
41204 Diagnoses - secondary ICD10 D35.6 Benign neoplasm: Aortic body and other paraganglia
40001 Underlying (primary) cause of death: ICD10 D32 Benign neoplasm of meninges
40001 Underlying (primary) cause of death: ICD10 D33 Benign neoplasm of brain and other parts of central nervous system
40001 Underlying (primary) cause of death: ICD10 D35.2 Benign neoplasm: Pituitary gland
40001 Underlying (primary) cause of death: ICD10 D35.3 Benign neoplasm: Craniopharyngeal duct
40001 Underlying (primary) cause of death: ICD10 D35.4 Benign neoplasm: Pineal gland
40001 Underlying (primary) cause of death: ICD10 D35.5 Benign neoplasm: Carotid body
40001 Underlying (primary) cause of death: ICD10 D35.6 Benign neoplasm: Aortic body and other paraganglia
40002 Contributory (secondary) causes of death: ICD10 D32 Benign neoplasm of meninges
40002 Contributory (secondary) causes of death: ICD10 D33 Benign neoplasm of brain and other parts of central nervous system
40002 Contributory (secondary) causes of death: ICD10 D35.2 Benign neoplasm: Pituitary gland
40002 Contributory (secondary) causes of death: ICD10 D35.3 Benign neoplasm: Craniopharyngeal duct
40002 Contributory (secondary) causes of death: ICD10 D35.4 Benign neoplasm: Pineal gland
40002 Contributory (secondary) causes of death: ICD10 D35.5 Benign neoplasm: Carotid body
40002 Contributory (secondary) causes of death: ICD10 D35.6 Benign neoplasm: Aortic body and other paraganglia
42040 GP clinical event records B7F0000 Benign neoplasm of brain, supratentorial
42040 GP clinical event records B7F0.00 Benign neoplasm of brain
42040 GP clinical event records B7F0.11 Cerebral tumour - benign
42040 GP clinical event records B7F1000 Acoustic neuroma
42040 GP clinical event records B7F1.00 Benign neoplasm of cranial nerves
42040 GP clinical event records B7F2000 Cerebral meningioma
42040 GP clinical event records B7F2.00 Benign neoplasm of cerebral meninges
42040 GP clinical event records B7F2z00 Benign neoplasm of cerebral meninges NOS
42040 GP clinical event records B7F3.00 Benign neoplasm of spinal cord
42040 GP clinical event records B7F4000 Spinal meningioma
42040 GP clinical event records B7F4.00 Benign neoplasm of spinal meninges
42040 GP clinical event records B7F4z00 Benign neoplasm of spinal meninges NOS
42040 GP clinical event records B7F..00 Benign neoplasm of brain and other parts of nervous system
42040 GP clinical event records B7FX.00 Benign neoplasm of meninges, unspecified
42040 GP clinical event records B7Fz.00 Benign neoplasm of brain or other nervous system NOS
42040 GP clinical event records B7H2000 Benign neoplasm of pituitary gland
42040 GP clinical event records B7H2100 Benign neoplasm of Rathke’s pouch
42040 GP clinical event records B7H2200 Benign neoplasm of sella turcica
42040 GP clinical event records B7H2300 Benign neoplasm of craniopharyngeal duct
42040 GP clinical event records B7H2.00 Benign neoplasm of pituitary gland and craniopharyngeal duct
42040 GP clinical event records B7H2.11 Pituitary adenoma
42040 GP clinical event records B7H2z00 Benign neoplasm of pituitary and craniopharyngeal duct NOS
42040 GP clinical event records B7H3.00 Benign neoplasm of pineal gland
42040 GP clinical event records B7H4.00 Benign neoplasm of carotid body
42040 GP clinical event records B7H5000 Benign neoplasm of glomus jugulare
42040 GP clinical event records B7H5100 Benign neoplasm of aortic body
42040 GP clinical event records B7H5200 Benign neoplasm of coccygeal body
42040 GP clinical event records B7H5.00 Benign neoplasm of aortic body and other paraganglia
42040 GP clinical event records B7H5z00 Benign neoplasm of aortic body and other paraganglia NOS
42040 GP clinical event records BBb5.00 [M]Choroid plexus papilloma NOS
42040 GP clinical event records BBd0.00 [M]Meningioma NOS
42040 GP clinical event records BBd3.00 [M]Meningotheliomatous meningioma
42040 GP clinical event records BBd3.11 [M]Endotheliomatous meningioma
42040 GP clinical event records BBd4.00 [M]Fibrous meningioma
42040 GP clinical event records BBd5.00 [M]Psammomatous meningioma
42040 GP clinical event records BBd6.00 [M]Angiomatous meningioma
42040 GP clinical event records BBd7.00 [M]Haemangioblastic meningioma
42040 GP clinical event records BBd7.11 [M]Angioblastic meningioma
42040 GP clinical event records BBd8.00 [M]Haemangiopericytic meningioma
42040 GP clinical event records BBd9.00 [M]Transitional meningioma
42040 GP clinical event records BBd..00 [M]Meningiomas
42040 GP clinical event records BBdz.00 [M]Meningioma NOS
42040 GP clinical event records BBe5.11 [M]Acoustic neuroma
42040 GP clinical event records BBdz. [M]Meningioma NOS
42040 GP clinical event records XE2vb Benign neoplasm of pituitary gland and craniopharyngeal duct
42040 GP clinical event records XE2va Benign neoplasm of brain and other parts of nervous system
40006 Type of cancer: ICD10 D32 Benign neoplasm of meninges
40006 Type of cancer: ICD10 D33 Benign neoplasm of brain and other parts of central nervous system
40006 Type of cancer: ICD10 D35.2 Benign neoplasm: Pituitary gland
40006 Type of cancer: ICD10 D35.3 Benign neoplasm: Craniopharyngeal duct
40006 Type of cancer: ICD10 D35.4 Benign neoplasm: Pineal gland
40006 Type of cancer: ICD10 D35.5 Benign neoplasm: Carotid body
40006 Type of cancer: ICD10 D35.6 Benign neoplasm: Aortic body and other paraganglia