Benign neoplasm of colon, rectum, anus and anal canal

Metadata

Name	Benign neoplasm of colon, rectum, anus and anal canal (benign_colon)
Category	Benign neoplasm or Carcinoma in situ
Sex
Adult	Yes
UUID	0c435921-7347-45a5-89d9-f7641c71a89b
Definition	An intestinal benign neoplasm that is located in the colon, rectum, anus or anal canal

Ontologies

Disease Ontology (DOID)	DOID_235
GWAS Catalogue	MONDO_0002278
SNOMED-CT	92170008
FinnGen	CD2_BENIGN_COLORECANI

Key Summary Statistics

Cases from any source

Total	53843
Female (%)	24573 (46%)
Male (%)	29270 (54%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	231.63 (221.51,241.75)
Male	340.46 (327.16,353.76)

Incidence stratified by sex

Female	52.99 (51.06,54.91)
Male	83.38 (80.71,86.06)

Incidence stratified by age

Ages 40-44	21.61 (18.7,24.52)
Ages 45-49	36.2 (32.95,39.45)
Ages 50-54	47.89 (44.41,51.36)
Ages 55-59	68.07 (64.29,71.84)
Ages 60-64	85.84 (82.17,89.51)
Ages 65-69	101.17 (96.57,105.77)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	262 (247,279)	541 (523,560)	904 (884,924)
CALIBER	174 (170,177)	388 (382,394)	706 (697,714)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	242(207,281)	502(464,543)	792(752,832)
Low	233(198,271)	490(452,530)	880(839,923)
Medium	252(217,291)	532(493,574)	845(804,888)
High	267(234,304)	559(519,601)	941(896,989)
Most deprived	300(268,335)	619(578,663)	1101(1049,1154)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	264(246,282)	548(527,568)	910(888,932)
Scotland	262(218,312)	540(492,592)	911(854,971)
Wales	254(199,319)	482(424,546)	835(768,907)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1460	rectal or colon adenoma/polyps
41202	Diagnoses - main ICD10	D12	Benign neoplasm of colon, rectum, anus and anal canal
41202	Diagnoses - main ICD10	K62.0	Anal polyp
41202	Diagnoses - main ICD10	K62.1	Rectal polyp
41202	Diagnoses - main ICD10	K63.5	Polyp of colon
41204	Diagnoses - secondary ICD10	D12	Benign neoplasm of colon, rectum, anus and anal canal
41204	Diagnoses - secondary ICD10	K62.0	Anal polyp
41204	Diagnoses - secondary ICD10	K62.1	Rectal polyp
41204	Diagnoses - secondary ICD10	K63.5	Polyp of colon
40001	Underlying (primary) cause of death: ICD10	D12	Benign neoplasm of colon, rectum, anus and anal canal
40001	Underlying (primary) cause of death: ICD10	K62.0	Anal polyp
40001	Underlying (primary) cause of death: ICD10	K62.1	Rectal polyp
40001	Underlying (primary) cause of death: ICD10	K63.5	Polyp of colon
40002	Contributory (secondary) causes of death: ICD10	D12	Benign neoplasm of colon, rectum, anus and anal canal
40002	Contributory (secondary) causes of death: ICD10	K62.0	Anal polyp
40002	Contributory (secondary) causes of death: ICD10	K62.1	Rectal polyp
40002	Contributory (secondary) causes of death: ICD10	K63.5	Polyp of colon
42040	GP clinical event records	771G400	Colonoscopic polypectomy
42040	GP clinical event records	7722.11	Open operation on rectal polyp
42040	GP clinical event records	7722.12	Open polypectomy of rectum
42040	GP clinical event records	7726111.0	Peranal excision of rectal polyp
42040	GP clinical event records	7726112.0	Peranal polypectomy of rectum
42040	GP clinical event records	7726212.0	Peranal destruction of rectal polyp
42040	GP clinical event records	7731200.0	Excision of anal polyp
42040	GP clinical event records	B713000	Benign neoplasm of hepatic flexure of colon
42040	GP clinical event records	B713100	Benign neoplasm of transverse colon
42040	GP clinical event records	B713200	Benign neoplasm of descending colon
42040	GP clinical event records	B713300	Benign neoplasm of sigmoid colon
42040	GP clinical event records	B713400	Benign neoplasm of caecum
42040	GP clinical event records	B713500	Benign neoplasm of appendix
42040	GP clinical event records	B713600	Benign neoplasm of ascending colon
42040	GP clinical event records	B713700	Benign neoplasm of splenic flexure of colon
42040	GP clinical event records	B713900	Benign neoplasm of ileocaecal valve
42040	GP clinical event records	B713.00	Benign neoplasm of colon
42040	GP clinical event records	B713.11	Colon polyp
42040	GP clinical event records	B713z00	Benign neoplasm of colon NOS
42040	GP clinical event records	B714000	Benign neoplasm of rectosigmoid junction
42040	GP clinical event records	B714100	Benign neoplasm of rectum
42040	GP clinical event records	B714111	Benign papilloma rectum
42040	GP clinical event records	B714200	Benign neoplasm of anal canal
42040	GP clinical event records	B714300	Benign neoplasm of anus NOS
42040	GP clinical event records	B714.00	Benign neoplasm of rectum and anal canal
42040	GP clinical event records	B714z00	Benign neoplasm of rectum or anal canal NOS
42040	GP clinical event records	J570000	Anal polyp
42040	GP clinical event records	J570100	Rectal polyp
42040	GP clinical event records	J570.00	Anal and rectal polyp
42040	GP clinical event records	J570z00	Anal and rectal polyp NOS
42040	GP clinical event records	J578.00	Colonic polyp
42040	GP clinical event records	J578.11	Polyp of colon
42040	GP clinical event records	X78o7	Benign neoplasm of ileocaecal valve
42040	GP clinical event records	X78Oa	Colonic polyp
42040	GP clinical event records	XE0Do	Peranal destruction of lesion of rectum
42040	GP clinical event records	XE0Dn	Peranal excision of lesion of rectum
42040	GP clinical event records	XaD2M	Colonoscopic polypectomy
40006	Type of cancer: ICD10	D12	Benign neoplasm of colon, rectum, anus and anal canal
40006	Type of cancer: ICD10	K62.0	Anal polyp
40006	Type of cancer: ICD10	K62.1	Rectal polyp
40006	Type of cancer: ICD10	K63.5	Polyp of colon