Benign neoplasm of ovary

Metadata

Name	Benign neoplasm of ovary (benign_ovary)
Category	Benign neoplasm or Carcinoma in situ
Sex
Adult	Yes
UUID	61a688cf-2cc6-443c-8027-9d4f26f088bb
Definition	A female reproductive organ benign neoplasm that is located in the ovary.

Ontologies

Disease Ontology (DOID)	DOID_0060112
SNOMED-CT	92260003
FinnGen	CD2_BENIGN_OVARY

Key Summary Statistics

Cases from any source

Total	11417
Female (%)	11417 (100%)
Male (%)	0 (0%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	352.92 (340.51,365.34)
Male	0.0 (0.0,0.0)

Incidence stratified by sex

Female	14.68 (13.66,15.69)
Male	0.0 (0.0,0.0)

Incidence stratified by age

Ages 40-44	13.32 (11.02,15.62)
Ages 45-49	10.5 (8.75,12.25)
Ages 50-54	8.08 (6.65,9.5)
Ages 55-59	5.74 (4.66,6.82)
Ages 60-64	6.37 (5.4,7.35)
Ages 65-69	7.14 (5.95,8.32)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	290 (275,306)	245 (234,256)	190 (182,199)
CALIBER	678 (668,688)	593 (582,603)	421 (411,430)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	291(254,331)	238(213,264)	184(166,204)
Low	270(235,308)	214(191,239)	189(171,208)
Medium	277(243,315)	239(215,265)	188(169,207)
High	311(278,348)	253(228,279)	179(160,199)
Most deprived	296(265,331)	281(254,309)	215(193,238)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	290(273,309)	243(231,256)	191(181,201)
Scotland	284(242,331)	256(226,289)	194(170,221)
Wales	299(243,364)	242(204,284)	177(148,210)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	D27	Benign neoplasm of ovary
41202	Diagnoses - main ICD10	N83.0	Follicular cyst of ovary
41202	Diagnoses - main ICD10	N83.1	Corpus luteum cyst
41202	Diagnoses - main ICD10	N83.2	Other and unspecified ovarian cysts
41204	Diagnoses - secondary ICD10	D27	Benign neoplasm of ovary
41204	Diagnoses - secondary ICD10	N83.0	Follicular cyst of ovary
41204	Diagnoses - secondary ICD10	N83.1	Corpus luteum cyst
41204	Diagnoses - secondary ICD10	N83.2	Other and unspecified ovarian cysts
40001	Underlying (primary) cause of death: ICD10	D27	Benign neoplasm of ovary
40001	Underlying (primary) cause of death: ICD10	N83.0	Follicular cyst of ovary
40001	Underlying (primary) cause of death: ICD10	N83.1	Corpus luteum cyst
40001	Underlying (primary) cause of death: ICD10	N83.2	Other and unspecified ovarian cysts
40002	Contributory (secondary) causes of death: ICD10	D27	Benign neoplasm of ovary
40002	Contributory (secondary) causes of death: ICD10	N83.0	Follicular cyst of ovary
40002	Contributory (secondary) causes of death: ICD10	N83.1	Corpus luteum cyst
40002	Contributory (secondary) causes of death: ICD10	N83.2	Other and unspecified ovarian cysts
42040	GP clinical event records	7E20300	Ovarian cystectomy
42040	GP clinical event records	7E23300	Open drainage of cyst of ovary
42040	GP clinical event records	7E25200	Endoscopic drainage of cyst of ovary
42040	GP clinical event records	7E25211	Laparoscopic drainage ovarian cyst
42040	GP clinical event records	7E29100	Transvaginal drainage of ovarian cyst
42040	GP clinical event records	7E2B000	Transvaginal ultrasound guided aspiration of ovarian cyst
42040	GP clinical event records	B7A2.00	Benign teratoma of ovary
42040	GP clinical event records	B7A..00	Benign neoplasm of ovary
42040	GP clinical event records	B7A..11	Dermoid cyst of ovary
42040	GP clinical event records	BB81.00	[M]Ovarian cystic, mucinous and serous neoplasms
42040	GP clinical event records	BB81z00	[M]Ovarian cystic, mucinous or serous neoplasm NOS
42040	GP clinical event records	K530.00	Follicular cyst of ovary
42040	GP clinical event records	K530.11	Graafian follicle cyst
42040	GP clinical event records	K531000	Corpus luteum cyst unspecified
42040	GP clinical event records	K531100	Corpus luteum cyst haemorrhage
42040	GP clinical event records	K531200	Corpus luteum cyst rupture
42040	GP clinical event records	K531.00	Corpus luteum cyst
42040	GP clinical event records	K531z00	Corpus luteum cyst NOS
42040	GP clinical event records	K532000	Corpus albicans cyst of the ovary
42040	GP clinical event records	K532100	Theca lutein cyst of the ovary
42040	GP clinical event records	K532300	Simple cystoma of the ovary
42040	GP clinical event records	K532.00	Other ovarian cysts
42040	GP clinical event records	K532z00	Ovarian cyst NOS
42040	GP clinical event records	K53..11	Ovarian cysts
42040	GP clinical event records	Kyu9500	[X]Other and unspecified ovarian cysts
42040	GP clinical event records	PC04.00	Developmental ovarian cyst
42040	GP clinical event records	ZV13G00	[V]Personal history of ovarian cyst
42040	GP clinical event records	X784V	Developmental ovarian cyst
42040	GP clinical event records	XE0eZ	Noninflammatory disorders of the ovary, fallopian tube and broad ligament
42040	GP clinical event records	XaMnS	Transvaginal ultrasound guided aspiration of ovarian cyst
42040	GP clinical event records	X78XE	Benign teratoma of ovary
42040	GP clinical event records	XE1wV	[M]Ovarian cystic, mucinous and serous neoplasms
42040	GP clinical event records	XE1wV	[M]Ovarian cystic, mucinous and serous neoplasms
42040	GP clinical event records	XE1wV	[M]Ovarian cystic, mucinous and serous neoplasms
40006	Type of cancer: ICD10	D27	Benign neoplasm of ovary
40006	Type of cancer: ICD10	N83.0	Follicular cyst of ovary
40006	Type of cancer: ICD10	N83.1	Corpus luteum cyst
40006	Type of cancer: ICD10	N83.2	Other and unspecified ovarian cysts