Benign neoplasm of stomach and duodenum

Metadata

Name	Benign neoplasm of stomach and duodenum (benign_stomach)
Category	Benign neoplasm or Carcinoma in situ
Sex
Adult	Yes
UUID	c5e928ed-6c0a-486e-9371-e3b27ba66eb9
Definition	Benign neoplasm of stomach and duodenum

Ontologies

GWAS Catalogue	MONDO_0021449
SNOMED-CT	92411005

Key Summary Statistics

Cases from any source

Total	12650
Female (%)	7826 (62%)
Male (%)	4824 (38%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	50.1 (45.35,54.85)
Male	38.64 (34.09,43.19)

Incidence stratified by sex

Female	16.47 (15.41,17.53)
Male	11.16 (10.21,12.11)

Incidence stratified by age

Ages 40-44	4.03 (2.78,5.28)
Ages 45-49	6.18 (4.85,7.5)
Ages 50-54	10.94 (9.31,12.58)
Ages 55-59	14.45 (12.75,16.16)
Ages 60-64	16.87 (15.29,18.46)
Ages 65-69	22.9 (20.78,25.01)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	43 (37,49)	100 (92,108)	178 (169,187)
CALIBER	28 (27,30)	69 (67,72)	129 (126,133)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	27(16,41)	92(76,110)	161(144,180)
Low	41(27,58)	101(84,119)	179(161,199)
Medium	28(17,42)	97(81,115)	182(164,203)
High	59(44,77)	99(83,117)	179(159,200)
Most deprived	52(39,68)	109(92,128)	192(171,215)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	46(39,54)	108(99,117)	190(180,200)
Scotland	28(15,48)	65(50,85)	109(91,131)
Wales	29(13,56)	77(56,105)	155(127,187)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	K31.7	Polyp of stomach and duodenum
41202	Diagnoses - main ICD10	D13.1	Benign neoplasm: Stomach
41202	Diagnoses - main ICD10	D13.2	Benign neoplasm: Duodenum
41202	Diagnoses - main ICD10	D13.3	Benign neoplasm: Other and unspecified parts of small intestine
41204	Diagnoses - secondary ICD10	K31.7	Polyp of stomach and duodenum
41204	Diagnoses - secondary ICD10	D13.1	Benign neoplasm: Stomach
41204	Diagnoses - secondary ICD10	D13.2	Benign neoplasm: Duodenum
41204	Diagnoses - secondary ICD10	D13.3	Benign neoplasm: Other and unspecified parts of small intestine
40001	Underlying (primary) cause of death: ICD10	K31.7	Polyp of stomach and duodenum
40001	Underlying (primary) cause of death: ICD10	D13.1	Benign neoplasm: Stomach
40001	Underlying (primary) cause of death: ICD10	D13.2	Benign neoplasm: Duodenum
40001	Underlying (primary) cause of death: ICD10	D13.3	Benign neoplasm: Other and unspecified parts of small intestine
40002	Contributory (secondary) causes of death: ICD10	K31.7	Polyp of stomach and duodenum
40002	Contributory (secondary) causes of death: ICD10	D13.1	Benign neoplasm: Stomach
40002	Contributory (secondary) causes of death: ICD10	D13.2	Benign neoplasm: Duodenum
40002	Contributory (secondary) causes of death: ICD10	D13.3	Benign neoplasm: Other and unspecified parts of small intestine
42040	GP clinical event records	7612000.0	Open excision of polyp of stomach
42040	GP clinical event records	B711000	Benign neoplasm of stomach cardia
42040	GP clinical event records	B711100	Benign neoplasm of pylorus of stomach
42040	GP clinical event records	B711200	Benign neoplasm of fundus of stomach
42040	GP clinical event records	B711300	Benign neoplasm of body of stomach
42040	GP clinical event records	B711400	Benign neoplasm of pyloric antrum
42040	GP clinical event records	B711.00	Benign neoplasm of stomach
42040	GP clinical event records	B711.11	Gastric polyp
42040	GP clinical event records	B711z00	Benign neoplasm of stomach NOS
42040	GP clinical event records	B712000	Benign neoplasm of duodenum
42040	GP clinical event records	B712011	Duodenal polyp
42040	GP clinical event records	B712100	Benign neoplasm of jejunum
42040	GP clinical event records	B712111	Jejunal polyp
42040	GP clinical event records	B712200	Benign neoplasm of ileum
42040	GP clinical event records	B712.00	Benign neoplasm of small intestine and duodenum
42040	GP clinical event records	B712z00	Benign neoplasm of small intestine or duodenum NOS
42040	GP clinical event records	J177.00	Gastric polyp
42040	GP clinical event records	J177.11	Polyp of stomach
42040	GP clinical event records	J178.00	Duodenal polyp
42040	GP clinical event records	J178.11	Polyp of duodenum
42040	GP clinical event records	X3025	Gastric polyp
42040	GP clinical event records	X78o1	Duodenal polyp
40006	Type of cancer: ICD10	K31.7	Polyp of stomach and duodenum
40006	Type of cancer: ICD10	D13.1	Benign neoplasm: Stomach
40006	Type of cancer: ICD10	D13.2	Benign neoplasm: Duodenum
40006	Type of cancer: ICD10	D13.3	Benign neoplasm: Other and unspecified parts of small intestine