Benign neoplasm and polyp of uterus

Metadata

Name	Benign neoplasm and polyp of uterus (benign_uterus)
Category	Benign neoplasm or Carcinoma in situ
Sex
Adult	Yes
UUID	aa3eded9-123f-44c2-9c98-b1c9661677d9
Definition	A female reproductive organ benign neoplasm that is located in the uterus.

Ontologies

Disease Ontology (DOID)	DOID_0060095
SNOMED-CT	92470003
FinnGen	CD2_BENIGN_UTERUS_OTH

Key Summary Statistics

Cases from any source

Total	13993
Female (%)	13993 (100%)
Male (%)	0 (0%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	334.77 (322.67,346.88)
Male	0.0 (0.0,0.0)

Incidence stratified by sex

Female	21.42 (20.19,22.65)
Male	0.0 (0.0,0.0)

Incidence stratified by age

Ages 40-44	12.5 (10.29,14.71)
Ages 45-49	17.21 (14.97,19.44)
Ages 50-54	14.55 (12.65,16.46)
Ages 55-59	11.02 (9.52,12.52)
Ages 60-64	8.87 (7.71,10.03)
Ages 65-69	8.32 (7.04,9.6)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	168 (157,181)	226 (216,237)	244 (235,254)
CALIBER	249 (243,255)	380 (372,388)	396 (387,405)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	177(149,209)	230(206,255)	234(214,256)
Low	167(140,198)	222(198,247)	247(226,269)
Medium	157(132,186)	234(210,260)	253(232,276)
High	165(141,192)	225(202,250)	240(219,263)
Most deprived	175(151,202)	224(201,249)	249(226,274)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	182(168,196)	234(222,247)	255(244,267)
Scotland	69(49,94)	148(125,174)	165(142,189)
Wales	196(152,250)	283(242,329)	259(223,298)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1352	uterine polyps
41202	Diagnoses - main ICD10	D26.1	Other benign neoplasm: Corpus uteri
41202	Diagnoses - main ICD10	D26.7	Other benign neoplasm: Other parts of uterus
41202	Diagnoses - main ICD10	D26.9	Other benign neoplasm: Uterus, unspecified
41202	Diagnoses - main ICD10	N84.0	Polyp of corpus uteri
41204	Diagnoses - secondary ICD10	D26.1	Other benign neoplasm: Corpus uteri
41204	Diagnoses - secondary ICD10	D26.7	Other benign neoplasm: Other parts of uterus
41204	Diagnoses - secondary ICD10	D26.9	Other benign neoplasm: Uterus, unspecified
41204	Diagnoses - secondary ICD10	N84.0	Polyp of corpus uteri
40001	Underlying (primary) cause of death: ICD10	D26.1	Other benign neoplasm: Corpus uteri
40001	Underlying (primary) cause of death: ICD10	D26.7	Other benign neoplasm: Other parts of uterus
40001	Underlying (primary) cause of death: ICD10	D26.9	Other benign neoplasm: Uterus, unspecified
40001	Underlying (primary) cause of death: ICD10	N84.0	Polyp of corpus uteri
40002	Contributory (secondary) causes of death: ICD10	D26.1	Other benign neoplasm: Corpus uteri
40002	Contributory (secondary) causes of death: ICD10	D26.7	Other benign neoplasm: Other parts of uterus
40002	Contributory (secondary) causes of death: ICD10	D26.9	Other benign neoplasm: Uterus, unspecified
40002	Contributory (secondary) causes of death: ICD10	N84.0	Polyp of corpus uteri
42040	GP clinical event records	7E0D311	Endoscopic endometrial polypectomy
42040	GP clinical event records	7E0D700	Endoscopic endometrial polypectomy
42040	GP clinical event records	B791000	Benign neoplasm of endometrium NEC
42040	GP clinical event records	B791100	Benign neoplasm of myometrium NEC
42040	GP clinical event records	B791200	Benign neoplasm of uterine fundus NEC
42040	GP clinical event records	B791.00	Benign neoplasm corpus uteri NEC
42040	GP clinical event records	B791z00	Benign neoplasm of corpus uteri NOS
42040	GP clinical event records	B79..00	Other benign neoplasm of uterus
42040	GP clinical event records	B79y.00	Benign neoplasm of other specified sites of uterus
42040	GP clinical event records	B79z.00	Benign neoplasm of uterus NOS
42040	GP clinical event records	ByuGB00	[X]Benign neoplasm of other parts of uterus
42040	GP clinical event records	K540.00	Polyp of the corpus uteri
42040	GP clinical event records	K540.11	Endometrial polyp
42040	GP clinical event records	XE06m	Endoscopic destruction of lesion of uterus NEC
42040	GP clinical event records	XM1Ha	Endoscopic endometrial polypectomy
40006	Type of cancer: ICD10	D26.1	Other benign neoplasm: Corpus uteri
40006	Type of cancer: ICD10	D26.7	Other benign neoplasm: Other parts of uterus
40006	Type of cancer: ICD10	D26.9	Other benign neoplasm: Uterus, unspecified
40006	Type of cancer: ICD10	N84.0	Polyp of corpus uteri