Infection of bones and joints

Metadata

Name	Infection of bones and joints (bone)
Category	Infections
Sex
Adult	Yes
UUID	3181fd9c-fdd9-4024-9013-f5f3c6337a35
Definition	Infection of bones and joints

Ontologies

MeSH	D001850
SNOMED-CT	312154004

Key Summary Statistics

Cases from any source

Total	3204
Female (%)	1239 (39%)
Male (%)	1965 (61%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	19.21 (16.27,22.16)
Male	35.0 (30.67,39.33)

Incidence stratified by sex

Female	1.27 (0.97,1.56)
Male	3.44 (2.91,3.97)

Incidence stratified by age

Ages 40-44	1.01 (0.38,1.63)
Ages 45-49	1.26 (0.66,1.86)
Ages 50-54	2.29 (1.54,3.03)
Ages 55-59	1.98 (1.35,2.61)
Ages 60-64	2.46 (1.86,3.07)
Ages 65-69	3.53 (2.7,4.35)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	19 (15,24)	27 (23,32)	32 (28,36)
CALIBER	22 (21,23)	32 (31,34)	43 (41,45)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	6(2,15)	14(8,22)	25(18,33)
Low	16(8,28)	24(16,34)	29(22,38)
Medium	22(12,35)	25(17,35)	21(15,28)
High	16(9,28)	27(18,37)	30(22,40)
Most deprived	31(21,43)	46(35,60)	57(46,70)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	21(16,26)	28(23,33)	31(27,35)
Scotland	6(1,17)	26(16,39)	31(21,44)
Wales	19(7,42)	26(14,45)	44(30,63)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.18 (0.74, 1.86)	0.489
BMI	obese	1.91 (1.2, 3.06)	0.00685
BMI	underweight	0 (0, Inf)	0.995
smoking	previous	1.29 (0.88, 1.87)	0.189
smoking	current	1.41 (0.81, 2.45)	0.23
hypertension	yes	1.93 (1.34, 2.77)	0.000403

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1308	osteomyelitis
41202	Diagnoses - main ICD10	A18.0	Tuberculosis of bones and joints
41202	Diagnoses - main ICD10	A54.4	Gonococcal infection of musculoskeletal system
41202	Diagnoses - main ICD10	B45.3	Osseous cryptococcosis
41202	Diagnoses - main ICD10	B67.2	Echinococcus granulosus infection of bone
41202	Diagnoses - main ICD10	B90.2	Sequelae of tuberculosis of bones and joints
41202	Diagnoses - main ICD10	M00	Pyogenic arthritis
41202	Diagnoses - main ICD10	M01	Direct infections of joint in infectious and parasitic diseases classified elsewhere
41202	Diagnoses - main ICD10	M46.2	Osteomyelitis of vertebra
41202	Diagnoses - main ICD10	M46.3	Infection of intervertebral disc (pyogenic)
41202	Diagnoses - main ICD10	M46.4	Discitis, unspecified
41202	Diagnoses - main ICD10	M46.5	Other infective spondylopathies
41202	Diagnoses - main ICD10	M49.0	Tuberculosis of spine
41202	Diagnoses - main ICD10	M49.1	Brucella spondylitis
41202	Diagnoses - main ICD10	M49.2	Enterobacterial spondylitis
41202	Diagnoses - main ICD10	M49.3	Spondylopathy in other infectious and parasitic diseases classified elsewhere
41202	Diagnoses - main ICD10	M86	Osteomyelitis
41202	Diagnoses - main ICD10	M90.0	Tuberculosis of bone
41202	Diagnoses - main ICD10	M90.1	Periostitis in other infectious diseases classified elsewhere
41202	Diagnoses - main ICD10	M90.2	Osteopathy in other infectious diseases classified elsewhere
41204	Diagnoses - secondary ICD10	A18.0	Tuberculosis of bones and joints
41204	Diagnoses - secondary ICD10	A54.4	Gonococcal infection of musculoskeletal system
41204	Diagnoses - secondary ICD10	B45.3	Osseous cryptococcosis
41204	Diagnoses - secondary ICD10	B67.2	Echinococcus granulosus infection of bone
41204	Diagnoses - secondary ICD10	B90.2	Sequelae of tuberculosis of bones and joints
41204	Diagnoses - secondary ICD10	M00	Pyogenic arthritis
41204	Diagnoses - secondary ICD10	M01	Direct infections of joint in infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M46.2	Osteomyelitis of vertebra
41204	Diagnoses - secondary ICD10	M46.3	Infection of intervertebral disc (pyogenic)
41204	Diagnoses - secondary ICD10	M46.4	Discitis, unspecified
41204	Diagnoses - secondary ICD10	M46.5	Other infective spondylopathies
41204	Diagnoses - secondary ICD10	M49.0	Tuberculosis of spine
41204	Diagnoses - secondary ICD10	M49.1	Brucella spondylitis
41204	Diagnoses - secondary ICD10	M49.2	Enterobacterial spondylitis
41204	Diagnoses - secondary ICD10	M49.3	Spondylopathy in other infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M86	Osteomyelitis
41204	Diagnoses - secondary ICD10	M90.0	Tuberculosis of bone
41204	Diagnoses - secondary ICD10	M90.1	Periostitis in other infectious diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M90.2	Osteopathy in other infectious diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	A18.0	Tuberculosis of bones and joints
40001	Underlying (primary) cause of death: ICD10	A54.4	Gonococcal infection of musculoskeletal system
40001	Underlying (primary) cause of death: ICD10	B45.3	Osseous cryptococcosis
40001	Underlying (primary) cause of death: ICD10	B67.2	Echinococcus granulosus infection of bone
40001	Underlying (primary) cause of death: ICD10	B90.2	Sequelae of tuberculosis of bones and joints
40001	Underlying (primary) cause of death: ICD10	M00	Pyogenic arthritis
40001	Underlying (primary) cause of death: ICD10	M01	Direct infections of joint in infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	M46.2	Osteomyelitis of vertebra
40001	Underlying (primary) cause of death: ICD10	M46.3	Infection of intervertebral disc (pyogenic)
40001	Underlying (primary) cause of death: ICD10	M46.4	Discitis, unspecified
40001	Underlying (primary) cause of death: ICD10	M46.5	Other infective spondylopathies
40001	Underlying (primary) cause of death: ICD10	M49.0	Tuberculosis of spine
40001	Underlying (primary) cause of death: ICD10	M49.1	Brucella spondylitis
40001	Underlying (primary) cause of death: ICD10	M49.2	Enterobacterial spondylitis
40001	Underlying (primary) cause of death: ICD10	M49.3	Spondylopathy in other infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	M86	Osteomyelitis
40001	Underlying (primary) cause of death: ICD10	M90.0	Tuberculosis of bone
40001	Underlying (primary) cause of death: ICD10	M90.1	Periostitis in other infectious diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	M90.2	Osteopathy in other infectious diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	A18.0	Tuberculosis of bones and joints
40002	Contributory (secondary) causes of death: ICD10	A54.4	Gonococcal infection of musculoskeletal system
40002	Contributory (secondary) causes of death: ICD10	B45.3	Osseous cryptococcosis
40002	Contributory (secondary) causes of death: ICD10	B67.2	Echinococcus granulosus infection of bone
40002	Contributory (secondary) causes of death: ICD10	B90.2	Sequelae of tuberculosis of bones and joints
40002	Contributory (secondary) causes of death: ICD10	M00	Pyogenic arthritis
40002	Contributory (secondary) causes of death: ICD10	M01	Direct infections of joint in infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M46.2	Osteomyelitis of vertebra
40002	Contributory (secondary) causes of death: ICD10	M46.3	Infection of intervertebral disc (pyogenic)
40002	Contributory (secondary) causes of death: ICD10	M46.4	Discitis, unspecified
40002	Contributory (secondary) causes of death: ICD10	M46.5	Other infective spondylopathies
40002	Contributory (secondary) causes of death: ICD10	M49.0	Tuberculosis of spine
40002	Contributory (secondary) causes of death: ICD10	M49.1	Brucella spondylitis
40002	Contributory (secondary) causes of death: ICD10	M49.2	Enterobacterial spondylitis
40002	Contributory (secondary) causes of death: ICD10	M49.3	Spondylopathy in other infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M86	Osteomyelitis
40002	Contributory (secondary) causes of death: ICD10	M90.0	Tuberculosis of bone
40002	Contributory (secondary) causes of death: ICD10	M90.1	Periostitis in other infectious diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M90.2	Osteopathy in other infectious diseases classified elsewhere