| Name |
Hyperplasia of prostate (BPH) |
| Category |
Genitourinary |
| Sex |
|
| Adult |
Yes |
| UUID |
9a8d5653-c944-46c8-af1f-1fcc4c260b29 |
| Definition |
A disease caused by hyperplastic process of non-transformed prostatic cells. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
30410 |
| Female (%) |
0 (0%) |
| Male (%) |
30410 (100%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
0.0 (0.0,0.0) |
| Male |
603.09 (585.63,620.55) |
Incidence stratified by sex
| Female |
0.0 (0.0,0.0) |
| Male |
90.31 (87.48,93.14) |
Incidence stratified by age
| Ages 40-44 |
5.34 (3.9,6.78) |
| Ages 45-49 |
12.31 (10.43,14.19) |
| Ages 50-54 |
21.54 (19.23,23.84) |
| Ages 55-59 |
37.6 (34.82,40.39) |
| Ages 60-64 |
53.81 (50.91,56.71) |
| Ages 65-69 |
73.49 (69.54,77.43) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
79 (70,89) |
316 (301,330) |
851 (831,871) |
| CALIBER |
112 (108,116) |
546 (537,556) |
1636 (1618, |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
78(58,103) |
330(297,365) |
834(793,877) |
| Low |
65(47,88) |
311(279,345) |
885(842,929) |
| Medium |
78(59,102) |
315(283,350) |
865(821,910) |
| High |
91(71,114) |
310(279,344) |
834(789,881) |
| Most deprived |
80(64,100) |
313(282,346) |
832(786,880) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
77(67,87) |
305(290,322) |
833(811,855) |
| Scotland |
71(48,101) |
315(277,357) |
862(804,922) |
| Wales |
115(78,163) |
417(360,480) |
1025(949,1106) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1516 |
bph / benign prostatic hypertrophy |
| 41202 |
Diagnoses - main ICD10 |
N40 |
Hyperplasia of prostate |
| 41204 |
Diagnoses - secondary ICD10 |
N40 |
Hyperplasia of prostate |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N40 |
Hyperplasia of prostate |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N40 |
Hyperplasia of prostate |
| 42040 |
GP clinical event records |
14E1.00 |
H/O: prostatism |
| 42040 |
GP clinical event records |
1AA..00 |
Prostatism |
| 42040 |
GP clinical event records |
K200.00 |
Prostatic hyperplasia unspecified |
| 42040 |
GP clinical event records |
K201.00 |
Prostatic hyperplasia of the lateral lobe |
| 42040 |
GP clinical event records |
K202.00 |
Prostatic hyperplasia of the medial lobe |
| 42040 |
GP clinical event records |
K20..00 |
Benign prostatic hypertrophy |
| 42040 |
GP clinical event records |
K20..14 |
Enlarged prostate - benign |
| 42040 |
GP clinical event records |
K20..15 |
BPH - benign prostatic hypertrophy |
| 42040 |
GP clinical event records |
K20..16 |
Prostatism |
| 42040 |
GP clinical event records |
K20z.00 |
Prostatic hyperplasia NOS |