| Name |
Bronchiectasis (bronchiectasis) |
| Category |
Respiratory |
| Sex |
|
| Adult |
Yes |
| UUID |
580daec7-7b1b-4458-af6a-f6ffcb55fe2c |
| Definition |
Bronchiectasis is a long-term condition where the airways of the lungs become abnormally widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
7087 |
| Female (%) |
3993 (56%) |
| Male (%) |
3094 (44%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
69.08 (63.5,74.65) |
| Male |
55.58 (50.13,61.03) |
Incidence stratified by sex
| Female |
7.09 (6.39,7.78) |
| Male |
7.08 (6.32,7.84) |
Incidence stratified by age
| Ages 40-44 |
2.52 (1.53,3.51) |
| Ages 45-49 |
2.45 (1.62,3.29) |
| Ages 50-54 |
3.56 (2.63,4.49) |
| Ages 55-59 |
6.44 (5.3,7.57) |
| Ages 60-64 |
8.73 (7.59,9.87) |
| Ages 65-69 |
13.86 (12.21,15.5) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
26 (21,31) |
55 (49,61) |
134 (126,141) |
| CALIBER |
21 (20,22) |
52 (49,54) |
128 (125,132) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
25(15,39) |
49(38,62) |
115(101,131) |
| Low |
22(13,36) |
49(38,62) |
135(119,152) |
| Medium |
21(12,34) |
55(43,69) |
137(121,155) |
| High |
21(13,34) |
57(45,71) |
122(106,139) |
| Most deprived |
37(26,50) |
65(52,80) |
164(144,185) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
26(21,32) |
58(51,65) |
139(131,148) |
| Scotland |
28(16,47) |
49(35,66) |
109(90,131) |
| Wales |
19(7,41) |
38(23,59) |
117(93,146) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153513, Events=116
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.85 (1.14, 2.99) |
0.0128 |
| BMI |
obese |
1.9 (1.12, 3.22) |
0.0174 |
| BMI |
underweight |
0 (0, Inf) |
0.993 |
| smoking |
previous |
0.82 (0.53, 1.27) |
0.367 |
| smoking |
current |
1.79 (1.09, 2.95) |
0.0215 |
| hypertension |
yes |
1.55 (1.01, 2.37) |
0.0432 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 22174 |
Recent medication for bronchiectasis |
1 |
Yes |
| 22134 |
Doctor diagnosed bronchiectasis |
1 |
Yes |
| 20002 |
Non-cancer illness code, self-reported |
1114 |
bronchiectasis |
| 41202 |
Diagnoses - main ICD10 |
J47 |
Bronchiectasis |
| 41202 |
Diagnoses - main ICD10 |
Q33.4 |
Congenital bronchiectasis |
| 41204 |
Diagnoses - secondary ICD10 |
J47 |
Bronchiectasis |
| 41204 |
Diagnoses - secondary ICD10 |
Q33.4 |
Congenital bronchiectasis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
J47 |
Bronchiectasis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
Q33.4 |
Congenital bronchiectasis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
J47 |
Bronchiectasis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
Q33.4 |
Congenital bronchiectasis |
| 42040 |
GP clinical event records |
A115.00 |
Tuberculous bronchiectasis |
| 42040 |
GP clinical event records |
H340.00 |
Recurrent bronchiectasis |
| 42040 |
GP clinical event records |
H341.00 |
Post-infective bronchiectasis |
| 42040 |
GP clinical event records |
H34..00 |
Bronchiectasis |
| 42040 |
GP clinical event records |
H34z.00 |
Bronchiectasis NOS |
| 42040 |
GP clinical event records |
P861.00 |
Congenital bronchiectasis |