Other Cardiomyopathy

Metadata

Name	Other Cardiomyopathy (cardiomyo_oth)
Category	Cardiovascular
Sex
Adult	Yes
UUID	4c74ee14-5ca8-41db-b7c9-b72bb6be621b
Definition	A disease of the heart muscle or myocardium proper.

Ontologies

Disease Ontology (DOID)	DOID_0050700
GWAS Catalogue	EFO_0000318
MeSH	D009202
SNOMED-CT	85898001
FinnGen	I9_CARDMYO

Key Summary Statistics

Cases from any source

Total	2753
Female (%)	921 (33%)
Male (%)	1832 (67%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	7.19 (5.39,8.99)
Male	21.98 (18.54,25.41)

Incidence stratified by sex

Female	1.86 (1.51,2.22)
Male	4.35 (3.75,4.94)

Incidence stratified by age

Ages 40-44	0.7 (0.18,1.23)
Ages 45-49	1.26 (0.66,1.86)
Ages 50-54	2.22 (1.48,2.95)
Ages 55-59	2.65 (1.93,3.38)
Ages 60-64	3.62 (2.89,4.35)
Ages 65-69	5.44 (4.41,6.46)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	16 (12,20)	26 (22,30)	44 (40,48)
CALIBER	16 (15,17)	31 (30,33)	59 (57,61)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	10(4,21)	20(13,30)	34(26,43)
Low	11(5,22)	15(9,23)	42(33,53)
Medium	7(3,16)	24(16,34)	48(39,60)
High	17(9,28)	31(22,42)	46(36,57)
Most deprived	27(18,40)	37(28,49)	51(40,63)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	16(12,21)	26(22,31)	44(39,49)
Scotland	11(4,26)	22(13,35)	39(28,53)
Wales	20(7,44)	27(15,45)	52(36,72)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153996, Events=147

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.93 (0.63, 1.37)	0.695
BMI	obese	1 (0.64, 1.55)	0.987
BMI	underweight	0 (0, Inf)	0.994
smoking	previous	1.24 (0.87, 1.76)	0.231
smoking	current	1.53 (0.9, 2.59)	0.116
hypertension	yes	1.65 (1.18, 2.3)	0.00322

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	I25.5	Ischaemic cardiomyopathy
41202	Diagnoses - main ICD10	I42.3	Endomyocardial (eosinophilic) disease
41202	Diagnoses - main ICD10	I42.5	Other restrictive cardiomyopathy
41202	Diagnoses - main ICD10	I42.7	Cardiomyopathy due to drugs and other external agents
41202	Diagnoses - main ICD10	I42.8	Other cardiomyopathies
41202	Diagnoses - main ICD10	I42.9	Cardiomyopathy, unspecified
41202	Diagnoses - main ICD10	I43	Cardiomyopathy in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	I25.5	Ischaemic cardiomyopathy
41204	Diagnoses - secondary ICD10	I42.3	Endomyocardial (eosinophilic) disease
41204	Diagnoses - secondary ICD10	I42.5	Other restrictive cardiomyopathy
41204	Diagnoses - secondary ICD10	I42.7	Cardiomyopathy due to drugs and other external agents
41204	Diagnoses - secondary ICD10	I42.8	Other cardiomyopathies
41204	Diagnoses - secondary ICD10	I42.9	Cardiomyopathy, unspecified
41204	Diagnoses - secondary ICD10	I43	Cardiomyopathy in diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	I25.5	Ischaemic cardiomyopathy
40001	Underlying (primary) cause of death: ICD10	I42.3	Endomyocardial (eosinophilic) disease
40001	Underlying (primary) cause of death: ICD10	I42.5	Other restrictive cardiomyopathy
40001	Underlying (primary) cause of death: ICD10	I42.7	Cardiomyopathy due to drugs and other external agents
40001	Underlying (primary) cause of death: ICD10	I42.8	Other cardiomyopathies
40001	Underlying (primary) cause of death: ICD10	I42.9	Cardiomyopathy, unspecified
40001	Underlying (primary) cause of death: ICD10	I43	Cardiomyopathy in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	I25.5	Ischaemic cardiomyopathy
40002	Contributory (secondary) causes of death: ICD10	I42.3	Endomyocardial (eosinophilic) disease
40002	Contributory (secondary) causes of death: ICD10	I42.5	Other restrictive cardiomyopathy
40002	Contributory (secondary) causes of death: ICD10	I42.7	Cardiomyopathy due to drugs and other external agents
40002	Contributory (secondary) causes of death: ICD10	I42.8	Other cardiomyopathies
40002	Contributory (secondary) causes of death: ICD10	I42.9	Cardiomyopathy, unspecified
40002	Contributory (secondary) causes of death: ICD10	I43	Cardiomyopathy in diseases classified elsewhere
42040	GP clinical event records	C373300	Familial cardiac amyloid
42040	GP clinical event records	C373G00	Senile cardiac amyloidosis
42040	GP clinical event records	F391B00	Cardiomyopathy in Duchenne muscular dystrophy
42040	GP clinical event records	G343.00	Ischaemic cardiomyopathy
42040	GP clinical event records	G550.00	Endomyocardial fibrosis
42040	GP clinical event records	G552.00	Obscure African cardiomyopathy
42040	GP clinical event records	G554100	Constrictive cardiomyopathy
42040	GP clinical event records	G554200	Familial cardiomyopathy
42040	GP clinical event records	G554500	Takotsubo cardiomyopathy
42040	GP clinical event records	G554511	Stress cardiomyopathy
42040	GP clinical event records	G554.00	Other primary cardiomyopathies
42040	GP clinical event records	G554z00	Other primary cardiomyopathy NOS
42040	GP clinical event records	G557000	Amyloid heart disease
42040	GP clinical event records	G557011	Cardiac amyloidosis
42040	GP clinical event records	G557100	Beriberi heart disease
42040	GP clinical event records	G557500	Thyrotoxic heart disease
42040	GP clinical event records	G557.00	Nutritional and metabolic cardiomyopathies
42040	GP clinical event records	G557z00	Nutritional and metabolic cardiomyopathy NOS
42040	GP clinical event records	G558000	Cardiomyopathy in Friedreich’s ataxia
42040	GP clinical event records	G558100	Cardiomyopathy in myotonic dystrophy
42040	GP clinical event records	G558200	Dystrophic cardiomyopathy
42040	GP clinical event records	G558400	Amyloid cardiomyopathy
42040	GP clinical event records	G558.00	Cardiomyopathy in disease EC
42040	GP clinical event records	G558z00	Cardiomyopathy in diseases EC, NOS
42040	GP clinical event records	G559.00	Arrhythmogenic right ventricular cardiomyopathy
42040	GP clinical event records	G55A.00	Tachycardiomyopathy
42040	GP clinical event records	G55A.11	Tachycardia-induced cardiomyopathy
42040	GP clinical event records	G55..00	Cardiomyopathy
42040	GP clinical event records	G55y000	Cardiomyopathy due to drugs and other external agents
42040	GP clinical event records	G55y.00	Secondary cardiomyopathy NOS
42040	GP clinical event records	G55z.00	Cardiomyopathy NOS
42040	GP clinical event records	Gyu5N00	[X]Other restrictive cardiomyopathy
42040	GP clinical event records	Gyu5P00	[X]Other cardiomyopathies
42040	GP clinical event records	Gyu5R00	[X]Cardiomyopathy in metabolic diseases CE
42040	GP clinical event records	XE0V1	Secondary cardiomyopathy NOS
42040	GP clinical event records	Xa1fq	Arrhythmogenic right ventricular cardiomyopathy
42040	GP clinical event records	XaZSw	Senile cardiac amyloidosis
42040	GP clinical event records	XaZcx	Amyloid cardiomyopathy
42040	GP clinical event records	XaI9b	Cardiomyopathy in Duchenne muscular dystrophy
42040	GP clinical event records	XE0V0	Nutritional and metabolic cardiomyopathy NOS
42040	GP clinical event records	XaWye	Takotsubo cardiomyopathy
42040	GP clinical event records	XE0Uy	Obscure African cardiomyopathy