| Name |
Carpal tunnel syndrome (carpal_tunnel) |
| Category |
Musculoskeletal |
| Sex |
|
| Adult |
Yes |
| UUID |
0a386c75-c2ae-468e-b1a0-93230d178b40 |
| Definition |
Carpal tunnel syndrome (CTS) occurs when the median nerve, which runs from the forearm into the palm of the hand, becomes pressed or squeezed at the wrist. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
25353 |
| Female (%) |
17475 (69%) |
| Male (%) |
7878 (31%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
532.45 (517.34,547.56) |
| Male |
239.67 (228.45,250.88) |
Incidence stratified by sex
| Female |
35.05 (33.46,36.64) |
| Male |
21.42 (20.09,22.76) |
Incidence stratified by age
| Ages 40-44 |
21.67 (18.74,24.6) |
| Ages 45-49 |
30.45 (27.44,33.45) |
| Ages 50-54 |
34.15 (31.2,37.1) |
| Ages 55-59 |
29.67 (27.17,32.17) |
| Ages 60-64 |
26.55 (24.51,28.59) |
| Ages 65-69 |
28.77 (26.35,31.19) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
391 (373,411) |
555 (538,573) |
625 (609,641) |
| CALIBER |
427 (421,432) |
619 (612,627) |
719 (710,727) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
323(283,367) |
473(437,511) |
556(524,590) |
| Low |
384(341,432) |
519(481,560) |
601(568,636) |
| Medium |
401(358,448) |
535(497,575) |
631(596,667) |
| High |
380(341,422) |
572(533,613) |
645(608,683) |
| Most deprived |
451(411,493) |
674(632,719) |
710(670,753) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
417(396,440) |
588(567,608) |
656(638,675) |
| Scotland |
215(177,260) |
335(299,375) |
398(362,437) |
| Wales |
406(339,483) |
604(541,673) |
647(589,709) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153520, Events=195
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.39 (0.98, 1.99) |
0.068 |
| BMI |
obese |
1.63 (1.11, 2.4) |
0.0126 |
| BMI |
underweight |
0 (0, Inf) |
0.99 |
| smoking |
previous |
1.5 (1.1, 2.03) |
0.00988 |
| smoking |
current |
1.45 (0.93, 2.27) |
0.0986 |
| hypertension |
yes |
1.38 (0.98, 1.93) |
0.0624 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1541 |
carpal tunnel syndrome |
| 20004 |
Operation code |
1501 |
carpal tunnel surgery |
| 41202 |
Diagnoses - main ICD10 |
G56.0 |
Carpal tunnel syndrome |
| 41204 |
Diagnoses - secondary ICD10 |
G56.0 |
Carpal tunnel syndrome |
| 41200 |
Operative procedures - main OPCS4 |
A65.1 |
Carpal tunnel release |
| 41200 |
Operative procedures - main OPCS4 |
A69.2 |
Revision of carpal tunnel release |
| 41210 |
Operative procedures - secondary OPCS4 |
A65.1 |
A65.1 |
| 41210 |
Operative procedures - secondary OPCS4 |
A69.2 |
A69.2 |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G56.0 |
Carpal tunnel syndrome |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G56.0 |
Carpal tunnel syndrome |
| 42040 |
GP clinical event records |
7056000.0 |
Carpal tunnel release |
| 42040 |
GP clinical event records |
7056011.0 |
Carpal tunnel decompression |
| 42040 |
GP clinical event records |
7056200.0 |
Re-release of carpal tunnel |
| 42040 |
GP clinical event records |
7056400.0 |
Endoscopic carpal tunnel release |
| 42040 |
GP clinical event records |
705A100 |
Revision of carpal tunnel release |
| 42040 |
GP clinical event records |
85BE.00 |
Injection of carpal tunnel |
| 42040 |
GP clinical event records |
8Hlr.00 |
Referral for carpal tunnel injection |
| 42040 |
GP clinical event records |
9Nu3000 |
Consent given for carpal tunnel injection |
| 42040 |
GP clinical event records |
F340.00 |
Carpal tunnel syndrome |
| 42040 |
GP clinical event records |
F340.12 |
CTS - Carpal tunnel syndrome |
| 42040 |
GP clinical event records |
XaZbY |
Consent given for carpal tunnel injection |
| 42040 |
GP clinical event records |
XE15g |
Carpal tunnel syndrome |
| 42040 |
GP clinical event records |
XaZhO |
Referral for carpal tunnel injection |
| 120003 |
Ever had carpal tunnel syndrome |
1 |
yes |