Cerebral Palsy

Metadata

Name	Cerebral Palsy (cerebral_palsy)
Category	Neurological
Sex
Adult	Yes
UUID	a1e98833-1470-45f4-b4a6-5adf9fdbd6e0
Definition	A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain.

Ontologies

Disease Ontology (DOID)	DOID_1969
MeSH	D002547
SNOMED-CT	128188000
FinnGen	G6_CP

Key Summary Statistics

Cases from any source

Total	327
Female (%)	136 (42%)
Male (%)	191 (58%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	5.07 (3.55,6.58)
Male	8.96 (6.77,11.15)

Incidence stratified by sex

Female	0.12 (0.03,0.21)
Male	0.08 (0.0,0.17)

Incidence stratified by age

Ages 40-44	0.1 (-0.1,0.3)
Ages 45-49	0.3 (0.01,0.59)
Ages 50-54	0.0 (0.0,0.0)
Ages 55-59	0.05 (-0.05,0.15)
Ages 60-64	0.04 (-0.04,0.11)
Ages 65-69	0.2 (0.0,0.4)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	10 (7,13)	9 (7,12)	5 (4,7)
CALIBER	14 (13,15)	12 (11,13)	10 (9,11)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	5(1,13)	5(2,10)	2(1,5)
Low	5(1,14)	2(0,7)	3(1,7)
Medium	9(4,19)	11(6,18)	6(3,11)
High	6(2,13)	9(4,16)	7(4,12)
Most deprived	20(13,31)	18(12,27)	10(5,16)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	10(7,14)	8(6,11)	5(3,7)
Scotland	11(4,26)	14(7,25)	10(5,17)
Wales	6(1,22)	8(2,20)	4(1,13)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1433	cerebral palsy
41202	Diagnoses - main ICD10	G80	Cerebral palsy
41204	Diagnoses - secondary ICD10	G80	Cerebral palsy
40001	Underlying (primary) cause of death: ICD10	G80	Cerebral palsy
40002	Contributory (secondary) causes of death: ICD10	G80	Cerebral palsy
42040	GP clinical event records	38Gw.00	Gross Motor Function Classification System Cerebral Palsy
42040	GP clinical event records	F137000	Athetoid cerebral palsy
42040	GP clinical event records	F137011	Vogt’s disease
42040	GP clinical event records	F137100	Double athetosis
42040	GP clinical event records	F137111	Congenital athetosis
42040	GP clinical event records	F137.11	Athetoid cerebral palsy
42040	GP clinical event records	F137.12	Athetosis - congenital
42040	GP clinical event records	F230000	Congenital paraplegia
42040	GP clinical event records	F230100	Cerebral palsy with spastic diplegia
42040	GP clinical event records	F230111	Spastic diplegic cerebral palsy
42040	GP clinical event records	F230.00	Congenital diplegia
42040	GP clinical event records	F230.11	Paraplegia - congenital
42040	GP clinical event records	F230z00	Congenital diplegia NOS
42040	GP clinical event records	F231.00	Congenital hemiplegia
42040	GP clinical event records	F232.00	Congenital quadriplegia
42040	GP clinical event records	F232.11	Tetraplegia - congenital
42040	GP clinical event records	F233.00	Congenital monoplegia
42040	GP clinical event records	F233.11	Congenital spastic foot
42040	GP clinical event records	F234.00	Infantile hemiplegia NOS
42040	GP clinical event records	F23..00	Congenital cerebral palsy
42040	GP clinical event records	F23..11	Congenital spastic cerebral palsy
42040	GP clinical event records	F23..12	Infantile cerebral palsy
42040	GP clinical event records	F23..13	Littles disease
42040	GP clinical event records	F23..14	Cerebral atonia
42040	GP clinical event records	F23y000	Ataxic infantile cerebral palsy
42040	GP clinical event records	F23y100	Flaccid infantile cerebral palsy
42040	GP clinical event records	F23y200	Spastic cerebral palsy
42040	GP clinical event records	F23y300	Dyskinetic cerebral palsy
42040	GP clinical event records	F23y400	Ataxic diplegic cerebral palsy
42040	GP clinical event records	F23y500	Worster-Drought syndrome
42040	GP clinical event records	F23y511	Congenital suprabulbar paresis
42040	GP clinical event records	F23y600	Choreoathetoid cerebral palsy
42040	GP clinical event records	F23y.00	Other congenital cerebral palsy
42040	GP clinical event records	F23yz00	Other infantile cerebral palsy NOS
42040	GP clinical event records	F23z.00	Congenital cerebral palsy NOS
42040	GP clinical event records	F2B0.00	Spastic quadriplegic cerebral palsy
42040	GP clinical event records	F2B1.00	Spastic hemiplegic cerebral palsy
42040	GP clinical event records	F2B..00	Cerebral palsy
42040	GP clinical event records	F2By.00	Other cerebral palsy
42040	GP clinical event records	F2Bz.00	Cerebral palsy NOS
42040	GP clinical event records	Fyu9000	[X]Other infantile cerebral palsy
42040	GP clinical event records	Fyu9.00	[X]Cerebral palsy and other paralytic syndromes
42040	GP clinical event records	G669.00	Cerebral palsy, not congenital or infantile, acute
42040	GP clinical event records	XaYgp	Spastic quadriplegic cerebral palsy
42040	GP clinical event records	XE15M	Double athetosis
42040	GP clinical event records	XM1Pw	Congenital quadriplegia
42040	GP clinical event records	XaNWb	Worster-Drought syndrome
42040	GP clinical event records	XE2Q7	Athetoid cerebral palsy
42040	GP clinical event records	XaaVG	Gross Motor Function Classification System for Cerebral Palsy
42040	GP clinical event records	XaadE	Choreoathetoid cerebral palsy
42040	GP clinical event records	XM1Px	Congenital diplegia
42040	GP clinical event records	X00Eu	Dyskinetic cerebral palsy
42040	GP clinical event records	XM1Pu	Congenital cerebral palsy
42040	GP clinical event records	X00En	Spastic cerebral palsy
42040	GP clinical event records	XE2Q8	Cerebral palsy
42040	GP clinical event records	XE2Q9	Cerebral palsy with spastic diplegia
42040	GP clinical event records	XaYfK	Spastic hemiplegic cerebral palsy
42040	GP clinical event records	XE15V	Congenital monoplegia
42040	GP clinical event records	XE15L	Symptomatic torsion dystonia
42040	GP clinical event records	XaBE2	Cerebral palsy, not congenital or infantile, acute