Coronary heart disease not otherwise specified

Metadata

Name	Coronary heart disease not otherwise specified (CHD_NOS)
Category	Cardiovascular
Sex
Adult	Yes
UUID	9afda18f-4c1b-4613-b4af-119bec29ff1a
Definition	An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.

Ontologies

Disease Ontology (DOID)	DOID_3393
GWAS Catalogue	EFO_0001645
MeSH	D003324
SNOMED-CT	53741008
FinnGen	I9_CHD

Key Summary Statistics

Cases from any source

Total	52194
Female (%)	16601 (32%)
Male (%)	35593 (68%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	330.06 (318.03,342.08)
Male	915.0 (893.85,936.14)

Incidence stratified by sex

Female	22.72 (21.46,23.98)
Male	59.66 (57.34,61.98)

Incidence stratified by age

Ages 40-44	8.42 (6.61,10.23)
Ages 45-49	15.69 (13.55,17.82)
Ages 50-54	24.94 (22.43,27.45)
Ages 55-59	34.86 (32.14,37.58)
Ages 60-64	50.08 (47.22,52.93)
Ages 65-69	75.52 (71.4,79.64)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	183 (170,197)	539 (520,557)	1237 (1214,1261)
CALIBER	34 (32,35)	94 (91,97)	211 (207,216)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	123(98,153)	388(353,425)	1005(961,1052)
Low	136(109,167)	445(408,484)	1096(1049,1144)
Medium	147(120,178)	505(466,547)	1190(1140,1241)
High	164(138,193)	548(507,590)	1281(1227,1337)
Most deprived	299(266,334)	791(744,841)	1704(1640,1771)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	180(166,196)	537(517,558)	1239(1213,1265)
Scotland	215(174,261)	578(527,632)	1289(1220,1361)
Wales	165(121,220)	487(427,553)	1136(1057,1220)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=154060, Events=218

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.65, 1.23)	0.488
BMI	obese	1.16 (0.82, 1.63)	0.404
BMI	underweight	0 (0, Inf)	0.989
smoking	previous	1.75 (1.31, 2.35)	0.000182
smoking	current	2.37 (1.58, 3.55)	3.07e-05
hypertension	yes	1 (0.74, 1.36)	0.997

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1066	heart/cardiac problem
41202	Diagnoses - main ICD10	I25.0	Atherosclerotic cardiovascular disease, so described
41202	Diagnoses - main ICD10	I25.1	Atherosclerotic heart disease
41202	Diagnoses - main ICD10	I25.3	Aneurysm of heart
41202	Diagnoses - main ICD10	I25.4	Coronary artery aneurysm
41202	Diagnoses - main ICD10	I25.5	Ischaemic cardiomyopathy
41202	Diagnoses - main ICD10	I25.6	Silent myocardial ischaemia
41202	Diagnoses - main ICD10	I25.8	Other forms of chronic ischaemic heart disease
41202	Diagnoses - main ICD10	I25.9	Chronic ischaemic heart disease, unspecified
41204	Diagnoses - secondary ICD10	I25.0	Atherosclerotic cardiovascular disease, so described
41204	Diagnoses - secondary ICD10	I25.1	Atherosclerotic heart disease
41204	Diagnoses - secondary ICD10	I25.3	Aneurysm of heart
41204	Diagnoses - secondary ICD10	I25.4	Coronary artery aneurysm
41204	Diagnoses - secondary ICD10	I25.5	Ischaemic cardiomyopathy
41204	Diagnoses - secondary ICD10	I25.6	Silent myocardial ischaemia
41204	Diagnoses - secondary ICD10	I25.8	Other forms of chronic ischaemic heart disease
41204	Diagnoses - secondary ICD10	I25.9	Chronic ischaemic heart disease, unspecified
40001	Underlying (primary) cause of death: ICD10	I25.0	Atherosclerotic cardiovascular disease, so described
40001	Underlying (primary) cause of death: ICD10	I25.1	Atherosclerotic heart disease
40001	Underlying (primary) cause of death: ICD10	I25.3	Aneurysm of heart
40001	Underlying (primary) cause of death: ICD10	I25.4	Coronary artery aneurysm
40001	Underlying (primary) cause of death: ICD10	I25.5	Ischaemic cardiomyopathy
40001	Underlying (primary) cause of death: ICD10	I25.6	Silent myocardial ischaemia
40001	Underlying (primary) cause of death: ICD10	I25.8	Other forms of chronic ischaemic heart disease
40001	Underlying (primary) cause of death: ICD10	I25.9	Chronic ischaemic heart disease, unspecified
40002	Contributory (secondary) causes of death: ICD10	I25.0	Atherosclerotic cardiovascular disease, so described
40002	Contributory (secondary) causes of death: ICD10	I25.1	Atherosclerotic heart disease
40002	Contributory (secondary) causes of death: ICD10	I25.3	Aneurysm of heart
40002	Contributory (secondary) causes of death: ICD10	I25.4	Coronary artery aneurysm
40002	Contributory (secondary) causes of death: ICD10	I25.5	Ischaemic cardiomyopathy
40002	Contributory (secondary) causes of death: ICD10	I25.6	Silent myocardial ischaemia
40002	Contributory (secondary) causes of death: ICD10	I25.8	Other forms of chronic ischaemic heart disease
40002	Contributory (secondary) causes of death: ICD10	I25.9	Chronic ischaemic heart disease, unspecified
42040	GP clinical event records	14AL.00	H/O: Treatment for ischaemic heart disease
42040	GP clinical event records	6A2..00	Coronary heart disease annual review
42040	GP clinical event records	6A4..00	Coronary heart disease review
42040	GP clinical event records	8B3k.00	Coronary heart disease medication review
42040	GP clinical event records	8H2V.00	Admit ischaemic heart disease emergency
42040	GP clinical event records	G3…00	Ischaemic heart disease
42040	GP clinical event records	G3…11	Arteriosclerotic heart disease
42040	GP clinical event records	G3…12	Atherosclerotic heart disease
42040	GP clinical event records	G3…13	IHD - Ischaemic heart disease
42040	GP clinical event records	G31..00	Other acute and subacute ischaemic heart disease
42040	GP clinical event records	G311000	Myocardial infarction aborted
42040	GP clinical event records	G311011	MI - myocardial infarction aborted
42040	GP clinical event records	G31y.00	Other acute and subacute ischaemic heart disease
42040	GP clinical event records	G31y200	Subendocardial ischaemia
42040	GP clinical event records	G31y300	Transient myocardial ischaemia
42040	GP clinical event records	G31yz00	Other acute and subacute ischaemic heart disease NOS
42040	GP clinical event records	G34..00	Other chronic ischaemic heart disease
42040	GP clinical event records	G340.00	Coronary atherosclerosis
42040	GP clinical event records	G340.12	Coronary artery disease
42040	GP clinical event records	G343.00	Ischaemic cardiomyopathy
42040	GP clinical event records	G344.00	Silent myocardial ischaemia
42040	GP clinical event records	G34y.00	Other specified chronic ischaemic heart disease
42040	GP clinical event records	G34y100	Chronic myocardial ischaemia
42040	GP clinical event records	G34yz00	Other specified chronic ischaemic heart disease NOS
42040	GP clinical event records	G34z.00	Other chronic ischaemic heart disease NOS
42040	GP clinical event records	G34z000	Asymptomatic coronary heart disease
42040	GP clinical event records	G3y..00	Other specified ischaemic heart disease
42040	GP clinical event records	G3z..00	Ischaemic heart disease NOS
42040	GP clinical event records	Gyu3.00	[X]Ischaemic heart diseases
42040	GP clinical event records	Gyu3200	[X]Other forms of acute ischaemic heart disease
42040	GP clinical event records	Gyu3300	[X]Other forms of chronic ischaemic heart disease
42040	GP clinical event records	XaIfL	Coronary heart disease medication review
42040	GP clinical event records	XaFsH	Transient myocardial ischaemia
42040	GP clinical event records	XE2uV	Ischaemic heart disease
42040	GP clinical event records	XaIOW	Coronary heart disease review
42040	GP clinical event records	X200D	Silent myocardial ischaemia
42040	GP clinical event records	XM0rN	Coronary atherosclerosis
42040	GP clinical event records	XaBL4	H/O: Treatment for ischaemic heart disease
42040	GP clinical event records	XaNxN	Admit ischaemic heart disease emergency
42040	GP clinical event records	G31..	Other acute and subacute ischaemic heart disease
42040	GP clinical event records	XaG1Q	Asymptomatic coronary heart disease
42040	GP clinical event records	XaI9h	Coronary heart disease annual review