| Name |
Cholangitis (cholangitis) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
5209adeb-a352-4fdb-aca6-3a7541a8cb95 |
| Definition |
Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2155 |
| Female (%) |
949 (44%) |
| Male (%) |
1206 (56%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
7.31 (5.49,9.13) |
| Male |
8.4 (6.28,10.52) |
Incidence stratified by sex
| Female |
1.79 (1.45,2.14) |
| Male |
2.55 (2.09,3.0) |
Incidence stratified by age
| Ages 40-44 |
0.6 (0.12,1.09) |
| Ages 45-49 |
0.82 (0.33,1.3) |
| Ages 50-54 |
1.52 (0.91,2.13) |
| Ages 55-59 |
1.87 (1.26,2.48) |
| Ages 60-64 |
2.69 (2.06,3.32) |
| Ages 65-69 |
3.82 (2.96,4.68) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
6 (4,9) |
16 (13,20) |
27 (23,30) |
| CALIBER |
8 (7,9) |
15 (14,17) |
31 (29,33) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
5(1,14) |
4(1,10) |
23(17,31) |
| Low |
6(2,16) |
13(7,21) |
22(16,29) |
| Medium |
4(1,12) |
17(10,25) |
27(20,36) |
| High |
6(2,14) |
27(18,37) |
29(22,39) |
| Most deprived |
8(3,16) |
21(14,30) |
34(25,44) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
6(4,10) |
16(13,20) |
27(23,31) |
| Scotland |
6(1,19) |
17(10,28) |
23(15,34) |
| Wales |
4(0,21) |
19(9,34) |
31(19,48) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=154022, Events=131
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.27 (0.78, 2.07) |
0.333 |
| BMI |
obese |
2.62 (1.63, 4.22) |
6.84e-05 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.3 (0.9, 1.9) |
0.166 |
| smoking |
current |
1.71 (0.99, 2.95) |
0.0544 |
| hypertension |
yes |
1.97 (1.38, 2.82) |
0.000171 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1475 |
sclerosing cholangitis |
| 41202 |
Diagnoses - main ICD10 |
K80.3 |
Calculus of bile duct with cholangitis |
| 41202 |
Diagnoses - main ICD10 |
K83.0 |
Cholangitis |
| 41204 |
Diagnoses - secondary ICD10 |
K80.3 |
Calculus of bile duct with cholangitis |
| 41204 |
Diagnoses - secondary ICD10 |
K83.0 |
Cholangitis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K80.3 |
Calculus of bile duct with cholangitis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K83.0 |
Cholangitis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K80.3 |
Calculus of bile duct with cholangitis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K83.0 |
Cholangitis |
| 42040 |
GP clinical event records |
J620100 |
Liver abscess due to cholangitis |
| 42040 |
GP clinical event records |
J646.00 |
Calculus of bile duct with cholangitis |
| 42040 |
GP clinical event records |
J661000 |
Acute cholangitis |
| 42040 |
GP clinical event records |
J661100 |
Chronic cholangitis |
| 42040 |
GP clinical event records |
J661200 |
Recurrent cholangitis |
| 42040 |
GP clinical event records |
J661300 |
Suppurative cholangitis |
| 42040 |
GP clinical event records |
J661400 |
Ascending cholangitis |
| 42040 |
GP clinical event records |
J661500 |
Cholangitis lenta |
| 42040 |
GP clinical event records |
J661600 |
Obliterative cholangitis |
| 42040 |
GP clinical event records |
J661700 |
Primary sclerosing cholangitis |
| 42040 |
GP clinical event records |
J661800 |
Secondary sclerosing cholangitis |
| 42040 |
GP clinical event records |
J661900 |
Sclerosing cholangitis unspecified |
| 42040 |
GP clinical event records |
J661.00 |
Cholangitis |
| 42040 |
GP clinical event records |
J661y00 |
Other cholangitis |
| 42040 |
GP clinical event records |
J661z00 |
Cholangitis NOS |