Cholecystitis

Metadata

Name	Cholecystitis (cholecystitis)
Category	Digestive
Sex
Adult	Yes
UUID	6cca4686-7d8d-4471-9200-aebc35c526ab
Definition	A cholangitis that is characterized by an inflammation that is located in the gallbladder.

Ontologies

Disease Ontology (DOID)	DOID_1949
GWAS Catalogue	EFO_1001289
MeSH	D002764
SNOMED-CT	76581006
FinnGen	K11_CHOLECYST

Key Summary Statistics

Cases from any source

Total	16711
Female (%)	11041 (66%)
Male (%)	5670 (34%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	198.27 (188.89,207.65)
Male	89.46 (82.55,96.36)

Incidence stratified by sex

Female	18.5 (17.37,19.63)
Male	13.04 (12.01,14.07)

Incidence stratified by age

Ages 40-44	12.29 (10.1,14.49)
Ages 45-49	12.76 (10.84,14.68)
Ages 50-54	14.66 (12.76,16.57)
Ages 55-59	14.64 (12.91,16.37)
Ages 60-64	16.78 (15.18,18.37)
Ages 65-69	21.46 (19.4,23.53)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	164 (152,176)	209 (199,220)	297 (286,309)
CALIBER	179 (175,182)	234 (230,239)	315 (309,320)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	120(97,148)	190(168,215)	245(224,268)
Low	160(133,192)	198(175,223)	279(256,303)
Medium	149(123,178)	198(175,223)	294(270,319)
High	164(139,192)	225(201,252)	329(303,357)
Most deprived	209(182,238)	234(209,261)	355(326,385)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	162(149,176)	209(197,222)	297(285,310)
Scotland	157(125,195)	187(160,217)	281(251,314)
Wales	194(149,249)	250(210,295)	327(286,372)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=154022, Events=131

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.27 (0.78, 2.07)	0.333
BMI	obese	2.62 (1.63, 4.22)	6.84e-05
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	1.3 (0.9, 1.9)	0.166
smoking	current	1.71 (0.99, 2.95)	0.0544
hypertension	yes	1.97 (1.38, 2.82)	0.000171

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1163	cholecystitis
41202	Diagnoses - main ICD10	K80.0	Calculus of gallbladder with acute cholecystitis
41202	Diagnoses - main ICD10	K80.1	Calculus of gallbladder with other cholecystitis
41202	Diagnoses - main ICD10	K80.4	Calculus of bile duct with cholecystitis
41202	Diagnoses - main ICD10	K81	Cholecystitis
41204	Diagnoses - secondary ICD10	K80.0	Calculus of gallbladder with acute cholecystitis
41204	Diagnoses - secondary ICD10	K80.1	Calculus of gallbladder with other cholecystitis
41204	Diagnoses - secondary ICD10	K80.4	Calculus of bile duct with cholecystitis
41204	Diagnoses - secondary ICD10	K81	Cholecystitis
40001	Underlying (primary) cause of death: ICD10	K80.0	Calculus of gallbladder with acute cholecystitis
40001	Underlying (primary) cause of death: ICD10	K80.1	Calculus of gallbladder with other cholecystitis
40001	Underlying (primary) cause of death: ICD10	K80.4	Calculus of bile duct with cholecystitis
40001	Underlying (primary) cause of death: ICD10	K81	Cholecystitis
40002	Contributory (secondary) causes of death: ICD10	K80.0	Calculus of gallbladder with acute cholecystitis
40002	Contributory (secondary) causes of death: ICD10	K80.1	Calculus of gallbladder with other cholecystitis
40002	Contributory (secondary) causes of death: ICD10	K80.4	Calculus of bile duct with cholecystitis
40002	Contributory (secondary) causes of death: ICD10	K81	Cholecystitis
42040	GP clinical event records	J643000	Bile duct calculus + acute cholecystitis and no obstruction
42040	GP clinical event records	J643100	Bile duct calculus + acute cholecystitis and obstruction
42040	GP clinical event records	J643.00	Bile duct calculus with acute cholecystitis
42040	GP clinical event records	J643z00	Bile duct calculus + acute cholecystitis - obstruct NOS
42040	GP clinical event records	J644000	Bile duct calculus + other cholecystitis and no obstruction
42040	GP clinical event records	J644100	Bile duct calculus + other cholecystitis and obstruction
42040	GP clinical event records	J644.00	Bile duct calculus with other cholecystitis
42040	GP clinical event records	J644z00	Bile duct calculus + other cholecystitis - obstruction NOS
42040	GP clinical event records	J650000	Acute cholecystitis unspecified
42040	GP clinical event records	J650100	Acute angiocholecystitis
42040	GP clinical event records	J650200	Acute emphysematous cholecystitis
42040	GP clinical event records	J650300	Acute suppurative cholecystitis
42040	GP clinical event records	J650400	Acute gangrenous cholecystitis
42040	GP clinical event records	J650.00	Acute cholecystitis
42040	GP clinical event records	J650.11	Abscess of gallbladder
42040	GP clinical event records	J650.12	Empyema of gallbladder
42040	GP clinical event records	J650z00	Acute cholecystitis NOS
42040	GP clinical event records	J651000	Chronic cholecystitis
42040	GP clinical event records	J651.00	Other cholecystitis
42040	GP clinical event records	J651y00	Other cholecystitis OS
42040	GP clinical event records	J651z00	Cholecystitis NOS
42040	GP clinical event records	Jyu8100	[X]Other cholecystitis
42040	GP clinical event records	XE0bF	Acute cholecystitis