Cholelithiasis

Metadata

Name	Cholelithiasis (cholelithiasis)
Category	Digestive
Sex
Adult	Yes
UUID	11159edd-ef8a-4037-a004-04c6b8de552b
Definition	Cholelithiasis involves the presence of gallstones (see the image below), which are concretions that form in the biliary tract.

Ontologies

Disease Ontology (DOID)	DOID_10211
GWAS Catalogue	EFO_0004799
MeSH	D002769
SNOMED-CT	266474003
FinnGen	K11_CHOLELITH

Key Summary Statistics

Cases from any source

Total	35015
Female (%)	24083 (69%)
Male (%)	10932 (31%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	496.85 (482.23,511.48)
Male	198.65 (188.42,208.88)

Incidence stratified by sex

Female	36.58 (34.96,38.2)
Male	22.88 (21.5,24.26)

Incidence stratified by age

Ages 40-44	23.69 (20.63,26.75)
Ages 45-49	23.28 (20.67,25.89)
Ages 50-54	26.23 (23.66,28.8)
Ages 55-59	30.82 (28.28,33.36)
Ages 60-64	32.01 (29.78,34.24)
Ages 65-69	38.78 (35.96,41.61)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	304 (288,321)	403 (388,418)	553 (538,568)
CALIBER	323 (318,328)	442 (436,449)	621 (613,628)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	259(224,298)	353(322,386)	485(455,517)
Low	279(242,319)	358(327,391)	511(480,543)
Medium	264(230,303)	386(354,420)	549(516,583)
High	325(290,364)	418(385,454)	583(548,620)
Most deprived	366(330,404)	494(457,532)	662(622,703)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	286(268,304)	375(359,392)	519(503,536)
Scotland	392(341,450)	481(437,528)	716(667,768)
Wales	353(291,425)	541(481,606)	657(598,720)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=154022, Events=131

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.27 (0.78, 2.07)	0.333
BMI	obese	2.62 (1.63, 4.22)	6.84e-05
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	1.3 (0.9, 1.9)	0.166
smoking	current	1.71 (0.99, 2.95)	0.0544
hypertension	yes	1.97 (1.38, 2.82)	0.000171

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1162	cholelithiasis/gall stones
20004	Operation code	1528	gallstones removed
41202	Diagnoses - main ICD10	K80	Cholelithiasis
41204	Diagnoses - secondary ICD10	K80	Cholelithiasis
41200	Operative procedures - main OPCS4	J18	cholecystectomy
41210	Operative procedures - secondary OPCS4	J18	cholecystectomy
40001	Underlying (primary) cause of death: ICD10	K80	Cholelithiasis
40002	Contributory (secondary) causes of death: ICD10	K80	Cholelithiasis
42040	GP clinical event records	14CE.00	H/O: gall stones
42040	GP clinical event records	1965.00	Biliary colic
42040	GP clinical event records	1965.11	Biliary colic symptom
42040	GP clinical event records	4775.00	Faeces: gall stones present
42040	GP clinical event records	4G21.00	O/E: cholesterol gall stone
42040	GP clinical event records	4G22.00	O/E: pigment gall stone
42040	GP clinical event records	4G2..00	O/E: gall stone
42040	GP clinical event records	4G2Z.00	O/E: gall stone NOS
42040	GP clinical event records	7648700.0	Enterotomy and removal of gallstone
42040	GP clinical event records	8CMWD00	On gallstone care pathway
42040	GP clinical event records	J503000	Gallstone ileus
42040	GP clinical event records	J640000	Gallbladder calculus with acute cholecystitis +no obstruct
42040	GP clinical event records	J640100	Gallbladder calculus with acute cholecystitis + obstruction
42040	GP clinical event records	J640.00	Gallbladder calculus with acute cholecystitis
42040	GP clinical event records	J640z00	Gallbladder calculus with acute cholecystitis - obst NOS
42040	GP clinical event records	J641000	Gallbladder calculus with other cholecystitis +no obstruct
42040	GP clinical event records	J641100	Gallbladder calculus with other cholecystitis + obstruct
42040	GP clinical event records	J641.00	Gallbladder calculus with other cholecystitis
42040	GP clinical event records	J641z00	Gallbladder calculus with other cholecystitis - obstruct NOS
42040	GP clinical event records	J642000	Gallbladder calculus without mention cholecystitis +no obstr
42040	GP clinical event records	J642100	Gallbladder calculus without mention cholecystitis + obstruc
42040	GP clinical event records	J642200	Biliary colic
42040	GP clinical event records	J642.00	Gallbladder calculus without mention of cholecystitis
42040	GP clinical event records	J642.11	Gallbladder calculus without mention of cholecystitis
42040	GP clinical event records	J642z00	Gallbladder calculus without cholecystitis and obstruct NOS
42040	GP clinical event records	J643000	Bile duct calculus + acute cholecystitis and no obstruction
42040	GP clinical event records	J643100	Bile duct calculus + acute cholecystitis and obstruction
42040	GP clinical event records	J643.00	Bile duct calculus with acute cholecystitis
42040	GP clinical event records	J643z00	Bile duct calculus + acute cholecystitis - obstruct NOS
42040	GP clinical event records	J644000	Bile duct calculus + other cholecystitis and no obstruction
42040	GP clinical event records	J644100	Bile duct calculus + other cholecystitis and obstruction
42040	GP clinical event records	J644.00	Bile duct calculus with other cholecystitis
42040	GP clinical event records	J644z00	Bile duct calculus + other cholecystitis - obstruction NOS
42040	GP clinical event records	J645000	Bile duct calculus without cholecystitis, no obstruction
42040	GP clinical event records	J645100	Bile duct calculus without cholecystitis with obstruction
42040	GP clinical event records	J645200	Bile duct calculus NOS
42040	GP clinical event records	J645.00	Bile duct calculus without mention of cholecystitis
42040	GP clinical event records	J645.11	Choledocholithiasis
42040	GP clinical event records	J645z00	Bile duct calculus without cholecystitis NOS
42040	GP clinical event records	J646.00	Calculus of bile duct with cholangitis
42040	GP clinical event records	J64..00	Cholelithiasis
42040	GP clinical event records	J64..11	Bile duct calculus
42040	GP clinical event records	J64..12	Calculus - biliary
42040	GP clinical event records	J64..13	Cystic duct calculus
42040	GP clinical event records	J64..14	Gallbladder calculus
42040	GP clinical event records	J64..15	Gallstones
42040	GP clinical event records	J64..16	Stone - biliary
42040	GP clinical event records	J64z000	Cholelithiasis without obstruction NOS
42040	GP clinical event records	J64z100	Cholelithiasis with obstruction NOS
42040	GP clinical event records	J64z.00	Cholelithiasis NOS
42040	GP clinical event records	J64zz00	Cholelithiasis NOS
42040	GP clinical event records	J670500	Gallstone acute pancreatitis
42040	GP clinical event records	J671100	Gallstone chronic pancreatitis
42040	GP clinical event records	Jyu8000	[X]Other cholelithiasis
42040	GP clinical event records	XaaBJ	On gallstone care pathway
42040	GP clinical event records	XaJCM	H/O: gall stones
42040	GP clinical event records	1965.	Biliary colic
42040	GP clinical event records	XE0bE	Bile duct calculus without mention of cholecystitis
42040	GP clinical event records	J64z.	Cholelithiasis NOS
42040	GP clinical event records	XaE6v	Bile duct calculus NOS
42040	GP clinical event records	XaB9c	Enterotomy and removal of gallstone
42040	GP clinical event records	X308i	Gallstone acute pancreatitis
42040	GP clinical event records	X308u	Gallstone chronic pancreatitis