| Name |
Non-acute cystitis (chr_cystitis) |
| Category |
Genitourinary |
| Sex |
|
| Adult |
Yes |
| UUID |
de62641c-1acf-4415-8a1b-20d06154baf3 |
| Definition |
Interstitial cystitis is a poorly understood bladder condition that causes long-term pelvic pain and problems peeing. It’s also known as painful bladder syndrome. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1840 |
| Female (%) |
1200 (65%) |
| Male (%) |
640 (35%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
25.93 (22.51,29.36) |
| Male |
9.1 (6.89,11.31) |
Incidence stratified by sex
| Female |
2.33 (1.93,2.72) |
| Male |
1.79 (1.41,2.17) |
Incidence stratified by age
| Ages 40-44 |
0.91 (0.31,1.5) |
| Ages 45-49 |
0.89 (0.39,1.39) |
| Ages 50-54 |
1.46 (0.86,2.05) |
| Ages 55-59 |
1.77 (1.17,2.36) |
| Ages 60-64 |
2.73 (2.1,3.37) |
| Ages 65-69 |
3.43 (2.61,4.24) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
16 (12,20) |
24 (21,28) |
39 (35,44) |
| CALIBER |
14 (13,15) |
22 (21,23) |
39 (37,40) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
10(4,20) |
16(10,24) |
38(30,47) |
| Low |
10(4,20) |
13(7,20) |
40(32,50) |
| Medium |
20(12,33) |
27(19,38) |
38(30,48) |
| High |
17(10,28) |
34(26,46) |
35(27,45) |
| Most deprived |
19(11,29) |
30(22,40) |
46(36,58) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
17(13,21) |
25(21,29) |
41(37,46) |
| Scotland |
12(5,25) |
21(12,33) |
30(21,42) |
| Wales |
10(2,29) |
25(13,42) |
33(21,49) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
N30.1 |
Interstitial cystitis (chronic) |
| 41202 |
Diagnoses - main ICD10 |
N30.2 |
Other chronic cystitis |
| 41204 |
Diagnoses - secondary ICD10 |
N30.1 |
Interstitial cystitis (chronic) |
| 41204 |
Diagnoses - secondary ICD10 |
N30.2 |
Other chronic cystitis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N30.1 |
Interstitial cystitis (chronic) |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N30.2 |
Other chronic cystitis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N30.1 |
Interstitial cystitis (chronic) |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N30.2 |
Other chronic cystitis |
| 42040 |
GP clinical event records |
K151000 |
Hunner’s ulcer |
| 42040 |
GP clinical event records |
K151200 |
Submucous cystitis |
| 42040 |
GP clinical event records |
K151.00 |
Chronic interstitial cystitis |
| 42040 |
GP clinical event records |
K151z00 |
Chronic interstitial cystitis NOS |
| 42040 |
GP clinical event records |
K152000 |
Subacute cystitis |
| 42040 |
GP clinical event records |
K152.00 |
Other chronic cystitis |
| 42040 |
GP clinical event records |
K152y00 |
Chronic cystitis unspecified |
| 42040 |
GP clinical event records |
K152z00 |
Other chronic cystitis NOS |
| 42040 |
GP clinical event records |
K153.11 |
Follicular cystitis |
| 42040 |
GP clinical event records |
K15y000 |
Cystitis cystica |
| 42040 |
GP clinical event records |
Kyu5000 |
[X]Other chronic cystitis |
| 42040 |
GP clinical event records |
XE0dq |
Trigonitis |