Chronic viral hepatitis

Metadata

Name	Chronic viral hepatitis (chr_hep)
Category	Infections
Sex
Adult	Yes
UUID	34103789-944f-4214-8524-5c26393c6a77
Definition	Viral hepatitis is liver inflammation due to a viral infection.

Cases from any source

Total	1361
Female (%)	571 (42%)
Male (%)	790 (58%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	26.17 (22.73,29.61)
Male	31.08 (27.0,35.16)

Incidence stratified by sex

Female	0.55 (0.35,0.74)
Male	1.1 (0.8,1.4)

Incidence stratified by age

Ages 40-44	1.21 (0.53,1.9)
Ages 45-49	0.89 (0.39,1.4)
Ages 50-54	1.14 (0.62,1.67)
Ages 55-59	0.83 (0.43,1.24)
Ages 60-64	0.73 (0.4,1.06)
Ages 65-69	0.3 (0.06,0.54)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	42 (36,49)	40 (35,45)	24 (21,28)
CALIBER	46 (44,48)	40 (38,42)	22 (21,24)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	24(14,38)	28(20,39)	18(13,25)
Low	24(14,38)	27(19,38)	16(11,22)
Medium	33(22,49)	32(23,43)	22(15,29)
High	34(23,48)	41(30,53)	31(23,40)
Most deprived	79(63,99)	71(57,87)	39(30,51)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	43(36,50)	42(36,48)	26(22,30)
Scotland	44(27,68)	43(30,59)	21(13,31)
Wales	30(14,57)	19(9,34)	15(7,27)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1581	hepatitis d
41202	Diagnoses - main ICD10	B18	Chronic viral hepatitis
41204	Diagnoses - secondary ICD10	B18	Chronic viral hepatitis
40001	Underlying (primary) cause of death: ICD10	B18	Chronic viral hepatitis
40002	Contributory (secondary) causes of death: ICD10	B18	Chronic viral hepatitis
42040	GP clinical event records	141E.00	History of hepatitis B
42040	GP clinical event records	14i..00	H/O hepatitis C antiviral drug therapy
42040	GP clinical event records	2126700.0	Hepatitis C resolved
42040	GP clinical event records	43B4.00	Hepatitis B surface antig +ve
42040	GP clinical event records	43B5.00	Hepatitis e antigen present
42040	GP clinical event records	43j5.00	Hepatitis C nucleic acid detection
42040	GP clinical event records	43jG.00	Hepatitis B nucleic acid detection
42040	GP clinical event records	43X3.00	Hepatitis C antibody test positive
42040	GP clinical event records	4J3B.00	Hepatitis C viral load
42040	GP clinical event records	4J3D.00	Hepatitis B viral load
42040	GP clinical event records	4JQ3.00	Hepatitis C virus genotype
42040	GP clinical event records	4JQD.00	Hepatitis C viral ribonucleic acid PCR positive
42040	GP clinical event records	4JQD.11	Hepatitis C PCR positive
42040	GP clinical event records	4JQF.00	Hepatitis C antigen positive
42040	GP clinical event records	7Q05200	Hepatitis B treatment drugs Band 1
42040	GP clinical event records	8BB5.00	12 week virologic response to hepatitis C treatment
42040	GP clinical event records	9kR..00	Chronic hepatitis annual review - enhanced services admin
42040	GP clinical event records	9kV..00	Hepatitis C screening positive - enhanced services admin
42040	GP clinical event records	9kV..11	Hepatitis C screening positive
42040	GP clinical event records	9kX..00	Hepatitis status 6 months post treatment - enhanced serv adm
42040	GP clinical event records	9kZ..00	Hepatitis B screening positive - enhanced services admin
42040	GP clinical event records	9kZ..11	Hepatitis B screening positive
42040	GP clinical event records	9NgR.00	On hepatitis C treatment plan
42040	GP clinical event records	A703.00	Viral (serum) hepatitis B
42040	GP clinical event records	A705000	Viral hepatitis C without mention of hepatic coma
42040	GP clinical event records	A705100	Acute delta-(super)infection of hepatitis B carrier
42040	GP clinical event records	A707000	Chronic viral hepatitis B with delta-agent
42040	GP clinical event records	A707100	Chronic viral hepatitis B without delta-agent
42040	GP clinical event records	A707200	Chronic viral hepatitis C
42040	GP clinical event records	A707300	Chronic viral hepatitis B
42040	GP clinical event records	A707.00	Chronic viral hepatitis
42040	GP clinical event records	A707X00	Chronic viral hepatitis, unspecified
42040	GP clinical event records	A70A.00	Hepatitis C genotype 1
42040	GP clinical event records	A70B.00	Hepatitis C genotype 2
42040	GP clinical event records	A70C.00	Hepatitis C genotype 3
42040	GP clinical event records	A70D.00	Hepatitis C genotype 4
42040	GP clinical event records	A70z000	Hepatitis C
42040	GP clinical event records	AyuB100	[X]Other chronic viral hepatitis
42040	GP clinical event records	AyuB200	[X]Chronic viral hepatitis, unspecified
42040	GP clinical event records	Q409100	Congenital hepatitis B infection
42040	GP clinical event records	XaIrZ	Hepatitis C virus genotype
42040	GP clinical event records	X306k	Chronic viral hepatitis C
42040	GP clinical event records	XaXBp	Hepatitis C viral ribonucleic acid polymerase chain reaction positive
42040	GP clinical event records	XaZDB	H/O hepatitis C antiviral drug therapy
42040	GP clinical event records	XaLow	History of hepatitis B
42040	GP clinical event records	XaILY	Hepatitis C nucleic acid detection
42040	GP clinical event records	XaZ5S	Hepatitis C genotype 3
42040	GP clinical event records	XaIrP	Hepatitis B nucleic acid detection
42040	GP clinical event records	X306i	Chronic viral hepatitis B
42040	GP clinical event records	XaZDE	On hepatitis C treatment plan
42040	GP clinical event records	XaZ5T	Hepatitis C genotype 4
42040	GP clinical event records	XaIrY	Hepatitis C viral load
42040	GP clinical event records	XaZ5Q	Hepatitis C genotype 2
42040	GP clinical event records	XaFDz	Hepatitis C antibody test positive
42040	GP clinical event records	XaZ5P	Hepatitis C genotype 1
42040	GP clinical event records	X306h	Chronic viral hepatitis
42040	GP clinical event records	XaYbh	Hepatitis C antigen positive
42040	GP clinical event records	XaMEk	Hepatitis B treatment drugs Band 1
42040	GP clinical event records	XaMBL	Hepatitis B viral load
42040	GP clinical event records	XaZBl	12 week virologic response to hepatitis C treatment
42040	GP clinical event records	XaXET	Hepatitis C resolved