Cervical carcinoma in situ

Metadata

Name	Cervical carcinoma in situ (cin_cervical)
Category	Benign neoplasm or Carcinoma in situ
Sex
Adult	Yes
UUID	265d93e9-f187-4da3-b7ee-21ea562cff7b
Definition	A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.

Ontologies

Disease Ontology (DOID)	DOID_8991
GWAS Catalogue	EFO_0001061
MeSH	D018290
SNOMED-CT	92564006

Key Summary Statistics

Cases from any source

Total	34606
Female (%)	34606 (100%)
Male (%)	0 (0%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	2226.47 (2198.47,2254.46)
Male	0.0 (0.0,0.0)

Incidence stratified by sex

Female	55.17 (52.96,57.38)
Male	0.0 (0.0,0.0)

Incidence stratified by age

Ages 40-44	52.85 (47.98,57.72)
Ages 45-49	47.47 (43.48,51.46)
Ages 50-54	38.68 (35.36,42.0)
Ages 55-59	32.63 (29.89,35.37)
Ages 60-64	13.1 (11.61,14.58)
Ages 65-69	1.95 (1.3,2.59)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1406 (1371,1441)	1290 (1264,1316)	1075 (1055,1096)
CALIBER	444 (436,452)	315 (308,323)	189 (183,195)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	1504(1419,1591)	1294(1237,1353)	1050(1006,1095)
Low	1515(1431,1603)	1371(1312,1431)	1114(1069,1160)
Medium	1357(1280,1437)	1284(1228,1342)	1048(1004,1093)
High	1410(1338,1486)	1273(1218,1331)	1116(1069,1164)
Most deprived	1289(1222,1359)	1234(1179,1292)	1050(1002,1100)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	1631(1590,1673)	1523(1492,1555)	1260(1235,1285)
Scotland	285(243,332)	220(192,251)	178(155,203)
Wales	891(792,999)	775(706,849)	581(527,638)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1554	cervical intra-epithelial neoplasia (cin) / precancerous cells cervix
41202	Diagnoses - main ICD10	D06	Carcinoma in situ of cervix uteri
41202	Diagnoses - main ICD10	N87	Dysplasia of cervix uteri
41204	Diagnoses - secondary ICD10	D06	Carcinoma in situ of cervix uteri
41204	Diagnoses - secondary ICD10	N87	Dysplasia of cervix uteri
40001	Underlying (primary) cause of death: ICD10	D06	Carcinoma in situ of cervix uteri
40001	Underlying (primary) cause of death: ICD10	N87	Dysplasia of cervix uteri
40002	Contributory (secondary) causes of death: ICD10	D06	Carcinoma in situ of cervix uteri
40002	Contributory (secondary) causes of death: ICD10	N87	Dysplasia of cervix uteri
42040	GP clinical event records	4K2..11	Dyskaryosis on cervical smear
42040	GP clinical event records	4K2J.00	Cervical smear - low grade dyskaryosis
42040	GP clinical event records	4K2K.00	Cervical smear - high grade dyskaryosis (moderate)
42040	GP clinical event records	4K2L.00	Cervical smear - high grade dyskaryosis (severe)
42040	GP clinical event records	4K2N.00	Cervical smear - ?endocervical type glandular neoplasia
42040	GP clinical event records	4K2P.00	Cervical smear - ?non-cervical type glandular neoplasia
42040	GP clinical event records	B831000	Carcinoma in situ of endocervix
42040	GP clinical event records	B831100	Carcinoma in situ of exocervix
42040	GP clinical event records	B831.00	Carcinoma in situ of cervix uteri
42040	GP clinical event records	B831.11	CIN III - carcinoma in situ of cervix
42040	GP clinical event records	B831.12	Cervical intraepithelial neoplasia
42040	GP clinical event records	B831.13	Cervical intraepithelial neoplasia grade III
42040	GP clinical event records	ByuFA00	[X]Carcinoma in situ of other parts of cervix
42040	GP clinical event records	K551000	Anaplasia of cervix
42040	GP clinical event records	K551100	Epidermidization of cervix
42040	GP clinical event records	K551300	Mild cervical dysplasia
42040	GP clinical event records	K551311	Cervical intraepithelial neoplasia grade I
42040	GP clinical event records	K551400	Moderate cervical dysplasia
42040	GP clinical event records	K551411	Cervical intraepithelial neoplasia grade II
42040	GP clinical event records	K551.00	Dysplasia of cervix uteri
42040	GP clinical event records	K551.12	CIN I - II, cervical dysplasia
42040	GP clinical event records	K551X00	Severe cervical dysplasia, not elsewhere classified
42040	GP clinical event records	K551z00	Dysplasia of cervix NOS
42040	GP clinical event records	R150000	[D]Dyskaryotic cervical smear
42040	GP clinical event records	ZV13B00	[V]Personal history of mild cervical dysplasia
42040	GP clinical event records	ZV13B11	[V]PH of cervical intraepithelial neoplasia, grade I
42040	GP clinical event records	ZV13C00	[V]Personal history of moderate cervical dysplasia
42040	GP clinical event records	ZV13C11	[V]PH of cervical intraepithelial neoplasia grade II
42040	GP clinical event records	ZV13D00	[V]Personal history of severe cervical dysplasia
42040	GP clinical event records	ZV13E00	[V]PH of cervical intraepithelial neoplasia, grade III
42040	GP clinical event records	XaIyL	[V]Personal history of moderate cervical dysplasia
42040	GP clinical event records	Xaafj	Cervical smear - high grade dyskaryosis (severe)
42040	GP clinical event records	Xaafp	Cervical smear - features of non-cervical type glandular neoplasia
42040	GP clinical event records	Xaafo	Cervical smear - features of endocervical type glandular neoplasia
42040	GP clinical event records	XE2QO	Dysplasia of cervix uteri
42040	GP clinical event records	XE2QO	Dysplasia of cervix uteri
42040	GP clinical event records	XaaU7	Cervical smear - low grade dyskaryosis
42040	GP clinical event records	XaIyK	[V]Personal history of mild cervical dysplasia
42040	GP clinical event records	Xaafi	Cervical smear - high grade dyskaryosis (moderate)
42040	GP clinical event records	XaIyM	[V]Personal history of severe cervical dysplasia
42040	GP clinical event records	XaIyN	[V]Personal history of cervical intraepithelial neoplasia, grade III
42040	GP clinical event records	XE277	Cervical smear result
40006	Type of cancer: ICD10	D06	Carcinoma in situ of cervix uteri
40006	Type of cancer: ICD10	N87	Dysplasia of cervix uteri