Metadata

Name Liver fibrosis, sclerosis and cirrhosis (cirrhosis)
Category Digestive
Sex
Adult Yes
UUID b347e65d-768e-4d9a-8452-b783c80b525c
Definition Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, is a condition in which the liver does not function properly due to long-term damage. This damage is characterized by the replacement of normal liver tissue by scar tissue.

Ontologies

Disease Ontology (DOID) DOID_5082
GWAS Catalogue EFO_0001422
MeSH D008103
SNOMED-CT 19943007
FinnGen CIRRHOSIS_BROAD

Key Summary Statistics

Cases from any source

Total 3512
Female (%) 1258 (36%)
Male (%) 2254 (64%)

Year first recorded

cirrhosis year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced cirrhosis cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of cirrhosis

Baseline prevalence stratified by sex

Female 18.39 (15.51,21.27)
Male 38.64 (34.09,43.19)

Incidence stratified by sex

Female 2.64 (2.22,3.06)
Male 5.33 (4.67,5.98)

Incidence stratified by age

Ages 40-44 1.91 (1.05,2.77)
Ages 45-49 2.38 (1.55,3.2)
Ages 50-54 4.0 (3.01,4.99)
Ages 55-59 4.28 (3.35,5.2)
Ages 60-64 4.47 (3.66,5.28)
Ages 65-69 4.53 (3.6,5.47)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB cirrhosis prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 29 (24,35) 51 (46,57) 62 (57,67)
CALIBER 40 (38,42) 66 (64,68) 73 (70,76)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 19(10,32) 27(18,37) 49(39,60)
Low 21(11,34) 32(23,44) 44(35,54)
Medium 28(17,43) 40(30,53) 54(44,66)
High 26(17,40) 57(44,72) 70(57,84)
Most deprived 44(32,58) 98(82,117) 102(87,120)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 26(21,32) 46(40,53) 57(52,63)
Scotland 37(22,59) 77(59,98) 89(71,109)
Wales 48(26,81) 58(39,84) 73(54,97)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor Level Hazard Ratio P value
BMI overweight 1.07 (0.82, 1.39) 0.637
BMI obese 2.13 (1.65, 2.77) 1.06e-08
BMI underweight 0 (0, Inf) 0.986
smoking previous 1.48 (1.19, 1.85) 0.000498
smoking current 2.47 (1.87, 3.26) 1.43e-10
hypertension yes 2.21 (1.8, 2.72) 5.76e-14

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1158 liver failure/cirrhosis
20002 Non-cancer illness code, self-reported 1604 alcoholic liver disease / alcoholic cirrhosis
41202 Diagnoses - main ICD10 K70.1 Alcoholic hepatitis
41202 Diagnoses - main ICD10 K70.2 Alcoholic fibrosis and sclerosis of liver
41202 Diagnoses - main ICD10 K70.3 Alcoholic cirrhosis of liver
41202 Diagnoses - main ICD10 K71.7 Toxic liver disease with fibrosis and cirrhosis of liver
41202 Diagnoses - main ICD10 K74.0 Hepatic fibrosis
41202 Diagnoses - main ICD10 K74.1 Hepatic sclerosis
41202 Diagnoses - main ICD10 K74.2 Hepatic fibrosis with hepatic sclerosis
41202 Diagnoses - main ICD10 K74.4 Secondary biliary cirrhosis
41202 Diagnoses - main ICD10 K74.5 Biliary cirrhosis, unspecified
41202 Diagnoses - main ICD10 K74.6 Other and unspecified cirrhosis of liver
41204 Diagnoses - secondary ICD10 K70.1 Alcoholic hepatitis
41204 Diagnoses - secondary ICD10 K70.2 Alcoholic fibrosis and sclerosis of liver
41204 Diagnoses - secondary ICD10 K70.3 Alcoholic cirrhosis of liver
41204 Diagnoses - secondary ICD10 K71.7 Toxic liver disease with fibrosis and cirrhosis of liver
41204 Diagnoses - secondary ICD10 K74.0 Hepatic fibrosis
41204 Diagnoses - secondary ICD10 K74.1 Hepatic sclerosis
41204 Diagnoses - secondary ICD10 K74.2 Hepatic fibrosis with hepatic sclerosis
41204 Diagnoses - secondary ICD10 K74.4 Secondary biliary cirrhosis
41204 Diagnoses - secondary ICD10 K74.5 Biliary cirrhosis, unspecified
41204 Diagnoses - secondary ICD10 K74.6 Other and unspecified cirrhosis of liver
40001 Underlying (primary) cause of death: ICD10 K70.1 Alcoholic hepatitis
40001 Underlying (primary) cause of death: ICD10 K70.2 Alcoholic fibrosis and sclerosis of liver
40001 Underlying (primary) cause of death: ICD10 K70.3 Alcoholic cirrhosis of liver
40001 Underlying (primary) cause of death: ICD10 K71.7 Toxic liver disease with fibrosis and cirrhosis of liver
40001 Underlying (primary) cause of death: ICD10 K74.0 Hepatic fibrosis
40001 Underlying (primary) cause of death: ICD10 K74.1 Hepatic sclerosis
40001 Underlying (primary) cause of death: ICD10 K74.2 Hepatic fibrosis with hepatic sclerosis
40001 Underlying (primary) cause of death: ICD10 K74.4 Secondary biliary cirrhosis
40001 Underlying (primary) cause of death: ICD10 K74.5 Biliary cirrhosis, unspecified
40001 Underlying (primary) cause of death: ICD10 K74.6 Other and unspecified cirrhosis of liver
40002 Contributory (secondary) causes of death: ICD10 K70.1 Alcoholic hepatitis
40002 Contributory (secondary) causes of death: ICD10 K70.2 Alcoholic fibrosis and sclerosis of liver
40002 Contributory (secondary) causes of death: ICD10 K70.3 Alcoholic cirrhosis of liver
40002 Contributory (secondary) causes of death: ICD10 K71.7 Toxic liver disease with fibrosis and cirrhosis of liver
40002 Contributory (secondary) causes of death: ICD10 K74.0 Hepatic fibrosis
40002 Contributory (secondary) causes of death: ICD10 K74.1 Hepatic sclerosis
40002 Contributory (secondary) causes of death: ICD10 K74.2 Hepatic fibrosis with hepatic sclerosis
40002 Contributory (secondary) causes of death: ICD10 K74.4 Secondary biliary cirrhosis
40002 Contributory (secondary) causes of death: ICD10 K74.5 Biliary cirrhosis, unspecified
40002 Contributory (secondary) causes of death: ICD10 K74.6 Other and unspecified cirrhosis of liver
42040 GP clinical event records C310400 Glycogenosis with hepatic cirrhosis
42040 GP clinical event records C350012 Pigmentary cirrhosis of liver
42040 GP clinical event records C370800 Cystic fibrosis related cirrhosis
42040 GP clinical event records G852200 Oesophageal varices in cirrhosis of the liver
42040 GP clinical event records G852300 Oesophageal varices in alcoholic cirrhosis of the liver
42040 GP clinical event records J612000 Alcoholic fibrosis and sclerosis of liver
42040 GP clinical event records J612.00 Alcoholic cirrhosis of liver
42040 GP clinical event records J612.11 Florid cirrhosis
42040 GP clinical event records J612.12 Laennec’s cirrhosis
42040 GP clinical event records J613000 Alcoholic hepatic failure
42040 GP clinical event records J613.00 Alcoholic liver damage unspecified
42040 GP clinical event records J615100 Multilobular portal cirrhosis
42040 GP clinical event records J615300 Diffuse nodular cirrhosis
42040 GP clinical event records J615400 Fatty portal cirrhosis
42040 GP clinical event records J615500 Hypertrophic portal cirrhosis
42040 GP clinical event records J615600 Capsular portal cirrhosis
42040 GP clinical event records J615700 Cardiac portal cirrhosis
42040 GP clinical event records J615711 Congestive cirrhosis
42040 GP clinical event records J615800 Juvenile portal cirrhosis
42040 GP clinical event records J615812 Indian childhood cirrhosis
42040 GP clinical event records J615C00 Xanthomatous portal cirrhosis
42040 GP clinical event records J615D00 Bacterial portal cirrhosis
42040 GP clinical event records J615G00 Zooparasitic portal cirrhosis
42040 GP clinical event records J615H00 Infectious cirrhosis NOS
42040 GP clinical event records J615.00 Cirrhosis - non alcoholic
42040 GP clinical event records J615.11 Portal cirrhosis
42040 GP clinical event records J615y00 Portal cirrhosis unspecified
42040 GP clinical event records J615z00 Non-alcoholic cirrhosis NOS
42040 GP clinical event records J615z11 Macronodular cirrhosis of liver
42040 GP clinical event records J615z12 Cryptogenic cirrhosis of liver
42040 GP clinical event records J615z13 Cirrhosis of liver NOS
42040 GP clinical event records J615z15 Hepatic fibrosis
42040 GP clinical event records J616100 Secondary biliary cirrhosis
42040 GP clinical event records J616200 Biliary cirrhosis of children
42040 GP clinical event records J616.00 Biliary cirrhosis
42040 GP clinical event records J616z00 Biliary cirrhosis NOS
42040 GP clinical event records J617000 Chronic alcoholic hepatitis
42040 GP clinical event records J617.00 Alcoholic hepatitis
42040 GP clinical event records J61..00 Cirrhosis and chronic liver disease
42040 GP clinical event records J61y300 Portal fibrosis without cirrhosis
42040 GP clinical event records J61y400 Hepatic fibrosis
42040 GP clinical event records J61y500 Hepatic sclerosis
42040 GP clinical event records J61y600 Hepatic fibrosis with hepatic sclerosis
42040 GP clinical event records J635600 Toxic liver disease with fibrosis and cirrhosis of liver
42040 GP clinical event records Jyu7100 [X]Other and unspecified cirrhosis of liver
42040 GP clinical event records XaBE3 Chronic alcoholic hepatitis
42040 GP clinical event records XaXi9 Cystic fibrosis related cirrhosis
42040 GP clinical event records XE0b4 Alcoholic cirrhosis of liver
42040 GP clinical event records X3073 Alcoholic hepatic failure
42040 GP clinical event records X307Z Hepatic sclerosis
42040 GP clinical event records X307b Hepatic fibrosis with hepatic sclerosis
42040 GP clinical event records X3072 Alcoholic fibrosis and sclerosis of liver
42040 GP clinical event records XE0bA Non-alcoholic cirrhosis NOS
42040 GP clinical event records XE0b7 Cardiac portal cirrhosis
42040 GP clinical event records X306r Alcoholic hepatitis
42040 GP clinical event records XE0b8 Juvenile portal cirrhosis
42040 GP clinical event records XaC1d Oesophageal varices in alcoholic cirrhosis of the liver
42040 GP clinical event records XE0b6 Multilobular portal cirrhosis
42040 GP clinical event records XaBM6 Oesophageal varices in cirrhosis of the liver