| Name |
Coeliac disease (coeliac) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
59726ac7-30b5-4da9-924e-adf2c515322c |
| Definition |
An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
6078 |
| Female (%) |
4169 (69%) |
| Male (%) |
1909 (31%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
128.96 (121.37,136.55) |
| Male |
64.4 (58.53,70.26) |
Incidence stratified by sex
| Female |
2.49 (2.08,2.91) |
| Male |
2.2 (1.78,2.63) |
Incidence stratified by age
| Ages 40-44 |
1.01 (0.39,1.64) |
| Ages 45-49 |
2.1 (1.32,2.88) |
| Ages 50-54 |
2.24 (1.5,2.98) |
| Ages 55-59 |
2.21 (1.54,2.87) |
| Ages 60-64 |
2.56 (1.94,3.17) |
| Ages 65-69 |
3.19 (2.4,3.98) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
62 (54,70) |
71 (64,77) |
73 (67,79) |
| CALIBER |
37 (35,38) |
43 (41,45) |
53 (50,55) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
62(45,83) |
74(60,90) |
72(61,85) |
| Low |
77(58,100) |
69(56,85) |
74(63,87) |
| Medium |
50(36,69) |
66(53,81) |
71(60,84) |
| High |
61(46,80) |
79(65,96) |
68(56,82) |
| Most deprived |
60(46,77) |
66(53,81) |
79(66,94) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
63(55,72) |
71(64,79) |
71(65,77) |
| Scotland |
56(37,82) |
80(63,100) |
79(64,98) |
| Wales |
52(29,84) |
49(33,71) |
87(66,111) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.07 (0.82, 1.39) |
0.637 |
| BMI |
obese |
2.13 (1.65, 2.77) |
1.06e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.48 (1.19, 1.85) |
0.000498 |
| smoking |
current |
2.47 (1.87, 3.26) |
1.43e-10 |
| hypertension |
yes |
2.21 (1.8, 2.72) |
5.76e-14 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 21068 |
Diagnosed with coeliac disease or gluten sensitivity |
1 |
yes |
| 20002 |
Non-cancer illness code, self-reported |
1456 |
malabsorption/coeliac disease |
| 41202 |
Diagnoses - main ICD10 |
K90.0 |
Coeliac disease |
| 41204 |
Diagnoses - secondary ICD10 |
K90.0 |
Coeliac disease |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K90.0 |
Coeliac disease |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K90.0 |
Coeliac disease |
| 42040 |
GP clinical event records |
6648000.0 |
Coeliac disease annual review |
| 42040 |
GP clinical event records |
6648.00 |
Coeliac disease monitoring |
| 42040 |
GP clinical event records |
8IAp.00 |
Coeliac disease annual review declined |
| 42040 |
GP clinical event records |
9mB1.00 |
Coeliac disease monitoring invitation first letter |
| 42040 |
GP clinical event records |
9mB..00 |
Coeliac disease monitoring invitation |
| 42040 |
GP clinical event records |
J690000 |
Congenital coeliac disease |
| 42040 |
GP clinical event records |
J690100 |
Acquired coeliac disease |
| 42040 |
GP clinical event records |
J690.00 |
Coeliac disease |
| 42040 |
GP clinical event records |
J690.11 |
Coeliac rickets |
| 42040 |
GP clinical event records |
J690.12 |
Gee - Herter disease |
| 42040 |
GP clinical event records |
J690.13 |
Gluten enteropathy |
| 42040 |
GP clinical event records |
J690.14 |
Sprue - nontropical |
| 42040 |
GP clinical event records |
J690.15 |
Steatorrhea - idiopathic |
| 42040 |
GP clinical event records |
J690z00 |
Coeliac disease NOS |
| 42040 |
GP clinical event records |
ZC2C200 |
Dietary advice for coeliac disease |
| 42040 |
GP clinical event records |
XaXGm |
Coeliac disease annual review |
| 42040 |
GP clinical event records |
XE0bK |
Coeliac disease |
| 42040 |
GP clinical event records |
XE0bK |
Coeliac disease |
| 42040 |
GP clinical event records |
XaX0T |
Coeliac disease annual review declined |
| 42040 |
GP clinical event records |
XaX1x |
Coeliac disease monitoring invitation first letter |
| 42040 |
GP clinical event records |
XaX0R |
Coeliac disease monitoring invitation |