Collapsed vertebra

Metadata

Name	Collapsed vertebra (collapsed_vert)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	411001c5-ea09-495a-a570-6f94b5abff6c
Definition	A compression fracture is a collapse of a vertebra. It may be due to trauma or due to a weakening of the vertebra.

Ontologies

GWAS Catalogue	EFO_0003902
MeSH	D016103
SNOMED-CT	84138006
FinnGen	M13_VERTEBCOLLAPSE

Key Summary Statistics

Cases from any source

Total	2601
Female (%)	1449 (56%)
Male (%)	1152 (44%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	16.15 (13.45,18.85)
Male	20.3 (17.0,23.6)

Incidence stratified by sex

Female	2.89 (2.44,3.33)
Male	2.85 (2.37,3.33)

Incidence stratified by age

Ages 40-44	0.3 (-0.04,0.64)
Ages 45-49	1.04 (0.49,1.58)
Ages 50-54	1.58 (0.96,2.21)
Ages 55-59	2.55 (1.84,3.26)
Ages 60-64	3.39 (2.68,4.09)
Ages 65-69	6.04 (4.96,7.12)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	7 (5,10)	14 (12,18)	35 (31,39)
CALIBER	8 (8,9)	19 (18,21)	43 (41,45)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	3(0,10)	11(6,18)	27(21,36)
Low	10(4,20)	10(6,17)	30(23,39)
Medium	10(4,20)	8(4,14)	44(35,55)
High	2(0,8)	16(10,25)	36(27,46)
Most deprived	9(5,17)	26(18,36)	38(29,49)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	7(4,10)	14(11,18)	36(32,41)
Scotland	12(4,26)	17(9,28)	26(17,38)
Wales	6(1,22)	12(4,26)	37(24,54)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153520, Events=195

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.39 (0.98, 1.99)	0.068
BMI	obese	1.63 (1.11, 2.4)	0.0126
BMI	underweight	0 (0, Inf)	0.99
smoking	previous	1.5 (1.1, 2.03)	0.00988
smoking	current	1.45 (0.93, 2.27)	0.0986
hypertension	yes	1.38 (0.98, 1.93)	0.0624

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1646	facture vertebra/crush fracture/vertebral collapse
41202	Diagnoses - main ICD10	M48.5	Collapsed vertebra, not elsewhere classified
41202	Diagnoses - main ICD10	M49.5	Collapsed vertebra in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M48.5	Collapsed vertebra, not elsewhere classified
41204	Diagnoses - secondary ICD10	M49.5	Collapsed vertebra in diseases classified elsewhere
41200	Operative procedures - main OPCS4	V44	Decompression of fracture of spine
41200	Operative procedures - main OPCS4	V44.1	Complex decompression of fracture of spine
41200	Operative procedures - main OPCS4	V44.2	Anterior decompression of fracture of spine
41200	Operative procedures - main OPCS4	V44.3	Posterior decompression of fracture of spine NEC
41200	Operative procedures - main OPCS4	V44.4	Vertebroplasty of fracture of spine
41200	Operative procedures - main OPCS4	V44.5	Balloon kyphoplasty of fracture of spine
41200	Operative procedures - main OPCS4	V44.8	Other specified decompression of fracture of spine
41200	Operative procedures - main OPCS4	V44.9	Unspecified decompression of fracture of spine
41210	Operative procedures - secondary OPCS4	V44	V44
41210	Operative procedures - secondary OPCS4	V44.1	V44.1
41210	Operative procedures - secondary OPCS4	V44.2	V44.2
41210	Operative procedures - secondary OPCS4	V44.3	V44.3
41210	Operative procedures - secondary OPCS4	V44.4	V44.4
41210	Operative procedures - secondary OPCS4	V44.5	V44.5
41210	Operative procedures - secondary OPCS4	V44.8	V44.8
41210	Operative procedures - secondary OPCS4	V44.9	V44.9
40001	Underlying (primary) cause of death: ICD10	M48.5	Collapsed vertebra, not elsewhere classified
40001	Underlying (primary) cause of death: ICD10	M49.5	Collapsed vertebra in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M48.5	Collapsed vertebra, not elsewhere classified
40002	Contributory (secondary) causes of death: ICD10	M49.5	Collapsed vertebra in diseases classified elsewhere
42040	GP clinical event records	7J41300	Vertebroplasty of fracture of spine
42040	GP clinical event records	7J41500	Balloon kyphoplasty of fracture of spine
42040	GP clinical event records	7J48M00	Vertebroplasty
42040	GP clinical event records	N331000	Pathological fracture of thoracic vertebra
42040	GP clinical event records	N331011	Collapse of thoracic vertebra
42040	GP clinical event records	N331100	Pathological fracture of lumbar vertebra
42040	GP clinical event records	N331111	Collapse of lumbar vertebra
42040	GP clinical event records	N331800	Osteoporosis + pathological fracture lumbar vertebrae
42040	GP clinical event records	N331900	Osteoporosis + pathological fracture thoracic vertebrae
42040	GP clinical event records	N331A00	Osteoporosis + pathological fracture cervical vertebrae
42040	GP clinical event records	N331C00	Pathological fracture of cervical vertebra
42040	GP clinical event records	N331D00	Collapsed vertebra NOS
42040	GP clinical event records	N331E00	Collapse of cervical vertebra
42040	GP clinical event records	N331F00	Collapse of thoracic vertebra
42040	GP clinical event records	N331G00	Collapse of lumbar vertebra
42040	GP clinical event records	N331H00	Collapse of cervical vertebra due to osteoporosis
42040	GP clinical event records	N331J00	Collapse of lumbar vertebra due to osteoporosis
42040	GP clinical event records	N331K00	Collapse of thoracic vertebra due to osteoporosis
42040	GP clinical event records	N331L00	Collapse of vertebra due to osteoporosis NOS
42040	GP clinical event records	N331.11	Collapse of spine NOS
42040	GP clinical event records	N331.12	Collapse of vertebra NOS
42040	GP clinical event records	N331.14	Osteoporotic vertebral collapse
42040	GP clinical event records	Nyu6700	[X]Collapsed vertebra in diseases classified elsewhere
42040	GP clinical event records	S100H00	Closed fracture cervical vertebra, wedge
42040	GP clinical event records	S102100	Closed fracture thoracic vertebra, wedge
42040	GP clinical event records	S104100	Closed fracture lumbar vertebra, wedge
42040	GP clinical event records	S106000	Closed compression fracture sacrum
42040	GP clinical event records	XaD4I	Collapse of lumbar vertebra due to osteoporosis
42040	GP clinical event records	XaLxr	Vertebroplasty of fracture of spine
42040	GP clinical event records	XaMpT	Balloon kyphoplasty of fracture of spine
42040	GP clinical event records	XaBZT	Collapse of lumbar vertebra
42040	GP clinical event records	XaBMQ	Pathological fracture of cervical vertebra
42040	GP clinical event records	XaD4J	Collapse of thoracic vertebra due to osteoporosis
42040	GP clinical event records	XaBZS	Collapse of cervical vertebra
42040	GP clinical event records	XaIuu	Vertebroplasty
42040	GP clinical event records	XaD4K	Collapse of vertebra due to osteoporosis NOS
42040	GP clinical event records	XE2Qf	Pathological fracture of lumbar vertebra
42040	GP clinical event records	XE1GB	Pathological fracture
42040	GP clinical event records	XE2Qe	Pathological fracture of thoracic vertebra
42040	GP clinical event records	XaD2s	Collapse of cervical vertebra due to osteoporosis
42040	GP clinical event records	XaBMR	Collapsed vertebra NOS
42040	GP clinical event records	XaBZR	Collapse of thoracic vertebra