COPD excluding bronchitis

Metadata

Name	COPD excluding bronchitis (COPD_excl_bronchitis_NOS)
Category	Respiratory
Sex
Adult	Yes
UUID	c4899d93-0a72-4132-8fc3-b75ab6ac9396
Definition	A disease of chronic diffuse irreversible airflow obstruction. As per COPD, however “J40 Bronchitis, not specified as acute or chronic” removed.

Ontologies

Disease Ontology (DOID)	DOID_3083
GWAS Catalogue	EFO_0000341
MeSH	D029424
SNOMED-CT	13645005
FinnGen	J10_COPD

Key Summary Statistics

Cases from any source

Total	25577
Female (%)	11669 (46%)
Male (%)	13908 (54%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	139.92 (132.02,147.82)
Male	211.95 (201.39,222.51)

Incidence stratified by sex

Female	26.19 (24.84,27.53)
Male	37.15 (35.39,38.91)

Incidence stratified by age

Ages 40-44	8.79 (6.94,10.64)
Ages 45-49	9.7 (8.04,11.37)
Ages 50-54	19.83 (17.62,22.04)
Ages 55-59	29.45 (27.0,31.91)
Ages 60-64	40.56 (38.07,43.05)
Ages 65-69	56.48 (53.09,59.86)

Period prevalence

Methods

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	83 (74,92)	240 (228,252)	523 (508,538)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	25(15,40)	104(87,124)	288(264,313)
Low	38(25,56)	126(108,148)	361(334,388)
Medium	52(37,72)	164(142,187)	439(409,470)
High	73(56,93)	264(237,293)	595(558,633)
Most deprived	186(160,214)	524(486,564)	1036(986,1087)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	86(77,97)	243(229,257)	522(505,539)
Scotland	63(42,89)	248(216,283)	495(454,540)
Wales	78(50,116)	196(159,238)	576(520,636)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153513, Events=116

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.85 (1.14, 2.99)	0.0128
BMI	obese	1.9 (1.12, 3.22)	0.0174
BMI	underweight	0 (0, Inf)	0.993
smoking	previous	0.82 (0.53, 1.27)	0.367
smoking	current	1.79 (1.09, 2.95)	0.0215
hypertension	yes	1.55 (1.01, 2.37)	0.0432

Definition

UK Biobank field id	Description	Code	Value
22170	Recent medication for COPD	1	Yes
22130	Doctor diagnosed COPD (chronic obstructive pulmonary disease)	1	COPD
20002	Non-cancer illness code, self-reported	1112	chronic obstructive airways disease/copd
20002	Non-cancer illness code, self-reported	1472	emphysema
41202	Diagnoses - main ICD10	J41	Simple and mucopurulent chronic bronchitis
41202	Diagnoses - main ICD10	J42	Unspecified chronic bronchitis
41202	Diagnoses - main ICD10	J43	Emphysema
41202	Diagnoses - main ICD10	J44	Other chronic obstructive pulmonary disease
41204	Diagnoses - secondary ICD10	J41	Simple and mucopurulent chronic bronchitis
41204	Diagnoses - secondary ICD10	J42	Unspecified chronic bronchitis
41204	Diagnoses - secondary ICD10	J43	Emphysema
41204	Diagnoses - secondary ICD10	J44	Other chronic obstructive pulmonary disease
40001	Underlying (primary) cause of death: ICD10	J41	Simple and mucopurulent chronic bronchitis
40001	Underlying (primary) cause of death: ICD10	J42	Unspecified chronic bronchitis
40001	Underlying (primary) cause of death: ICD10	J43	Emphysema
40001	Underlying (primary) cause of death: ICD10	J44	Other chronic obstructive pulmonary disease
40002	Contributory (secondary) causes of death: ICD10	J41	Simple and mucopurulent chronic bronchitis
40002	Contributory (secondary) causes of death: ICD10	J42	Unspecified chronic bronchitis
40002	Contributory (secondary) causes of death: ICD10	J43	Emphysema
40002	Contributory (secondary) causes of death: ICD10	J44	Other chronic obstructive pulmonary disease
42040	GP clinical event records	14B3.12	History of chronic obstructive pulmonary disease
42040	GP clinical event records	H310000	Chronic catarrhal bronchitis
42040	GP clinical event records	H310.00	Simple chronic bronchitis
42040	GP clinical event records	H310z00	Simple chronic bronchitis NOS
42040	GP clinical event records	H311000	Purulent chronic bronchitis
42040	GP clinical event records	H311100	Fetid chronic bronchitis
42040	GP clinical event records	H311.00	Mucopurulent chronic bronchitis
42040	GP clinical event records	H311z00	Mucopurulent chronic bronchitis NOS
42040	GP clinical event records	H312000	Chronic asthmatic bronchitis
42040	GP clinical event records	H312011	Chronic wheezy bronchitis
42040	GP clinical event records	H312100	Emphysematous bronchitis
42040	GP clinical event records	H312200	Acute exacerbation of chronic obstructive airways disease
42040	GP clinical event records	H312300	Bronchiolitis obliterans
42040	GP clinical event records	H312.00	Obstructive chronic bronchitis
42040	GP clinical event records	H312z00	Obstructive chronic bronchitis NOS
42040	GP clinical event records	H313.00	Mixed simple and mucopurulent chronic bronchitis
42040	GP clinical event records	H31..00	Chronic bronchitis
42040	GP clinical event records	H31y100	Chronic tracheobronchitis
42040	GP clinical event records	H31y.00	Other chronic bronchitis
42040	GP clinical event records	H31yz00	Other chronic bronchitis NOS
42040	GP clinical event records	H31z.00	Chronic bronchitis NOS
42040	GP clinical event records	H320000	Segmental bullous emphysema
42040	GP clinical event records	H320100	Zonal bullous emphysema
42040	GP clinical event records	H320200	Giant bullous emphysema
42040	GP clinical event records	H320300	Bullous emphysema with collapse
42040	GP clinical event records	H320.00	Chronic bullous emphysema
42040	GP clinical event records	H320z00	Chronic bullous emphysema NOS
42040	GP clinical event records	H321.00	Panlobular emphysema
42040	GP clinical event records	H322.00	Centrilobular emphysema
42040	GP clinical event records	H32..00	Emphysema
42040	GP clinical event records	H32y000	Acute vesicular emphysema
42040	GP clinical event records	H32y100	Atrophic (senile) emphysema
42040	GP clinical event records	H32y111	Acute interstitial emphysema
42040	GP clinical event records	H32y200	MacLeod’s unilateral emphysema
42040	GP clinical event records	H32y.00	Other emphysema
42040	GP clinical event records	H32yz00	Other emphysema NOS
42040	GP clinical event records	H32z.00	Emphysema NOS
42040	GP clinical event records	H36..00	Mild chronic obstructive pulmonary disease
42040	GP clinical event records	H37..00	Moderate chronic obstructive pulmonary disease
42040	GP clinical event records	H38..00	Severe chronic obstructive pulmonary disease
42040	GP clinical event records	H39..00	Very severe chronic obstructive pulmonary disease
42040	GP clinical event records	H3A..00	End stage chronic obstructive airways disease
42040	GP clinical event records	H3…00	Chronic obstructive pulmonary disease
42040	GP clinical event records	H3…11	Chronic obstructive airways disease
42040	GP clinical event records	H3y0.00	Chronic obstruct pulmonary dis with acute lower resp infectn
42040	GP clinical event records	H3y1.00	Chron obstruct pulmonary dis wth acute exacerbation, unspec
42040	GP clinical event records	H3y..00	Other specified chronic obstructive airways disease
42040	GP clinical event records	H3y..11	Other specified chronic obstructive pulmonary disease
42040	GP clinical event records	H3z..00	Chronic obstructive airways disease NOS
42040	GP clinical event records	H3z..11	Chronic obstructive pulmonary disease NOS
42040	GP clinical event records	H464000	Chronic emphysema due to chemical fumes
42040	GP clinical event records	H464100	Obliterative bronchiolitis due to chemical fumes
42040	GP clinical event records	H583200	Eosinophilic bronchitis
42040	GP clinical event records	Hyu3000	[X]Other emphysema
42040	GP clinical event records	Hyu3100	[X]Other specified chronic obstructive pulmonary disease
42040	GP clinical event records	XE0YP	Other emphysema NOS
42040	GP clinical event records	XE0YM	Purulent chronic bronchitis
42040	GP clinical event records	XaEIY	Severe chronic obstructive pulmonary disease
42040	GP clinical event records	XaEIW	Moderate chronic obstructive pulmonary disease
42040	GP clinical event records	XaIND	End stage chronic obstructive airways disease
42040	GP clinical event records	XaEIV	Mild chronic obstructive pulmonary disease
42040	GP clinical event records	XE0YN	Bullous emphysema with collapse
42040	GP clinical event records	X101l	Bronchiolitis obliterans
42040	GP clinical event records	Xaa7C	Eosinophilic bronchitis
42040	GP clinical event records	X101i	Chronic obstructive pulmonary disease with acute exacerbation, unspecified
42040	GP clinical event records	XE0YO	Atrophic (senile) emphysema
42040	GP clinical event records	XaN4a	Very severe chronic obstructive pulmonary disease