Metadata
| Name | Crohn’s disease (crohns) |
| Category | Digestive |
| Sex | |
| Adult | Yes |
| UUID | 80a108a4-3c5b-449d-9634-27259d1ceb96 |
| Definition | A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement. |
Ontologies
| Disease Ontology (DOID) | DOID_8778 |
| GWAS Catalogue | EFO_0000384 |
| MeSH | D003424 |
| SNOMED-CT | 7620006 |
| FinnGen | K11_CROHN |
Key Summary Statistics
Cases from any source
| Total | 3214 |
| Female (%) | 1776 (55%) |
| Male (%) | 1438 (45%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 46.21 (41.64,50.77) |
| Male | 44.94 (40.03,49.84) |
Incidence stratified by sex
| Female | 1.64 (1.31,1.97) |
| Male | 1.84 (1.45,2.23) |
Incidence stratified by age
| Ages 40-44 | 1.82 (0.98,2.66) |
| Ages 45-49 | 1.42 (0.78,2.05) |
| Ages 50-54 | 1.65 (1.02,2.29) |
| Ages 55-59 | 1.93 (1.31,2.55) |
| Ages 60-64 | 1.97 (1.43,2.51) |
| Ages 65-69 | 1.46 (0.93,1.99) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 49 (42,56) | 49 (44,54) | 51 (47,56) |
| CALIBER | 52 (50,54) | 54 (52,56) | 56 (54,59) |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 37(24,54) | 40(30,53) | 48(38,58) |
| Low | 35(23,51) | 54(42,69) | 46(37,56) |
| Medium | 44(30,62) | 43(33,56) | 47(37,57) |
| High | 50(36,67) | 53(41,67) | 55(45,68) |
| Most deprived | 69(54,86) | 53(42,67) | 63(51,76) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 45(38,52) | 45(40,52) | 49(44,55) |
| Scotland | 73(51,101) | 61(46,80) | 59(45,76) |
| Wales | 53(30,88) | 61(41,86) | 59(42,80) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.07 (0.82, 1.39) | 0.637 |
| BMI | obese | 2.13 (1.65, 2.77) | 1.06e-08 |
| BMI | underweight | 0 (0, Inf) | 0.986 |
| smoking | previous | 1.48 (1.19, 1.85) | 0.000498 |
| smoking | current | 2.47 (1.87, 3.26) | 1.43e-10 |
| hypertension | yes | 2.21 (1.8, 2.72) | 5.76e-14 |
Genetic correlation
| Genetic correlation (rg) | P value |
| 0.95 | 1.84e-30 |
Published study: de Lange (2017)
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1462 | crohns disease |
| 41202 | Diagnoses - main ICD10 | K50 | Crohn’s disease [regional enteritis] |
| 41204 | Diagnoses - secondary ICD10 | K50 | Crohn’s disease [regional enteritis] |
| 40001 | Underlying (primary) cause of death: ICD10 | K50 | Crohn’s disease [regional enteritis] |
| 40002 | Contributory (secondary) causes of death: ICD10 | K50 | Crohn’s disease [regional enteritis] |
| 42040 | GP clinical event records | J08z900 | Orofacial Crohn’s disease |
| 42040 | GP clinical event records | J400000 | Regional enteritis of the duodenum |
| 42040 | GP clinical event records | J400100 | Regional enteritis of the jejunum |
| 42040 | GP clinical event records | J400200 | Crohn’s disease of the terminal ileum |
| 42040 | GP clinical event records | J400300 | Crohn’s disease of the ileum unspecified |
| 42040 | GP clinical event records | J400400 | Crohn’s disease of the ileum NOS |
| 42040 | GP clinical event records | J400500 | Exacerbation of Crohn’s disease of small intestine |
| 42040 | GP clinical event records | J400.00 | Regional enteritis of the small bowel |
| 42040 | GP clinical event records | J400z00 | Crohn’s disease of the small bowel NOS |
| 42040 | GP clinical event records | J401000 | Regional enteritis of the colon |
| 42040 | GP clinical event records | J401100 | Regional enteritis of the rectum |
| 42040 | GP clinical event records | J401200 | Exacerbation of Crohn’s disease of large intestine |
| 42040 | GP clinical event records | J401.00 | Regional enteritis of the large bowel |
| 42040 | GP clinical event records | J401z00 | Crohn’s disease of the large bowel NOS |
| 42040 | GP clinical event records | J401z11 | Crohn’s colitis |
| 42040 | GP clinical event records | J402.00 | Regional ileocolitis |
| 42040 | GP clinical event records | J40..00 | Regional enteritis - Crohn’s disease |
| 42040 | GP clinical event records | J40..11 | Crohn’s disease |
| 42040 | GP clinical event records | J40..12 | Granulomatous enteritis |
| 42040 | GP clinical event records | J40z.00 | Regional enteritis NOS |
| 42040 | GP clinical event records | J40z.11 | Crohn’s disease NOS |
| 42040 | GP clinical event records | Jyu4000 | [X]Other Crohn’s disease |
| 42040 | GP clinical event records | N031100 | Arthropathy in Crohn’s disease |
| 42040 | GP clinical event records | N045300 | Juvenile arthritis in Crohn’s disease |
| 42040 | GP clinical event records | ZR3S.00 | Crohn’s disease activity index |
| 42040 | GP clinical event records | ZR3S.11 | CDAI - Crohn’s disease activity index |
| 42040 | GP clinical event records | XaK6D | Exacerbation of Crohn’s disease of large intestine |
| 42040 | GP clinical event records | XE0af | Crohn’s disease of the large bowel NOS |
| 42040 | GP clinical event records | XaK6C | Exacerbation of Crohn’s disease of small intestine |