| Name |
Dilated cardiomyopathy (dcm) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
fbea7d4c-600e-422f-87d3-03e4a2faefa6 |
| Definition |
Dilated cardiomyopathy (DCM) is a disease of your heart muscle where it becomes stretched and thin. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1569 |
| Female (%) |
457 (29%) |
| Male (%) |
1112 (71%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
2.95 (1.79,4.1) |
| Male |
16.52 (13.54,19.5) |
Incidence stratified by sex
| Female |
0.97 (0.71,1.22) |
| Male |
2.7 (2.23,3.17) |
Incidence stratified by age
| Ages 40-44 |
0.2 (-0.08,0.48) |
| Ages 45-49 |
0.89 (0.39,1.39) |
| Ages 50-54 |
1.46 (0.86,2.05) |
| Ages 55-59 |
1.14 (0.67,1.62) |
| Ages 60-64 |
2.27 (1.69,2.85) |
| Ages 65-69 |
3.27 (2.47,4.06) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
10 (8,14) |
16 (13,20) |
26 (23,30) |
| CALIBER |
11 (10,11) |
21 (19,22) |
35 (33,36) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
6(2,15) |
14(8,23) |
22(15,30) |
| Low |
9(3,20) |
10(5,18) |
26(19,34) |
| Medium |
5(1,13) |
15(9,24) |
30(22,39) |
| High |
9(4,18) |
24(16,34) |
26(19,35) |
| Most deprived |
19(11,29) |
17(11,26) |
30(22,40) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
12(8,16) |
17(14,21) |
26(22,30) |
| Scotland |
4(0,15) |
10(4,19) |
28(18,41) |
| Wales |
6(1,22) |
18(8,34) |
28(17,44) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153996, Events=147
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.93 (0.63, 1.37) |
0.695 |
| BMI |
obese |
1 (0.64, 1.55) |
0.987 |
| BMI |
underweight |
0 (0, Inf) |
0.994 |
| smoking |
previous |
1.24 (0.87, 1.76) |
0.231 |
| smoking |
current |
1.53 (0.9, 2.59) |
0.116 |
| hypertension |
yes |
1.65 (1.18, 2.3) |
0.00322 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
I42.0 |
Dilated cardiomyopathy |
| 41202 |
Diagnoses - main ICD10 |
I42.6 |
Alcoholic cardiomyopathy |
| 41204 |
Diagnoses - secondary ICD10 |
I42.0 |
Dilated cardiomyopathy |
| 41204 |
Diagnoses - secondary ICD10 |
I42.6 |
Alcoholic cardiomyopathy |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I42.0 |
Dilated cardiomyopathy |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I42.6 |
Alcoholic cardiomyopathy |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I42.0 |
Dilated cardiomyopathy |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I42.6 |
Alcoholic cardiomyopathy |
| 42040 |
GP clinical event records |
G554000 |
Congestive cardiomyopathy |
| 42040 |
GP clinical event records |
G554400 |
Primary dilated cardiomyopathy |
| 42040 |
GP clinical event records |
G555.00 |
Alcoholic cardiomyopathy |
| 42040 |
GP clinical event records |
G55y.11 |
Secondary dilated cardiomyopathy |
| 42040 |
GP clinical event records |
XE0V1 |
Secondary cardiomyopathy NOS |
| 42040 |
GP clinical event records |
XE0Uz |
Congestive cardiomyopathy |