Delirium, not induced by alcohol and other psychoactive substances

Metadata

Name	Delirium, not induced by alcohol and other psychoactive substances (delirium)
Category	Psychiatric
Sex
Adult	Yes
UUID	769336a9-83d1-4ac9-9837-2a3b17d1e1a9
Definition	Delirium, not induced by alcohol and other psychoactive substances

Ontologies

Disease Ontology (DOID)	DOID_8645
SNOMED-CT	191507002
FinnGen	F5_DELIRIUM

Key Summary Statistics

Cases from any source

Total	6148
Female (%)	2635 (43%)
Male (%)	3513 (57%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	1.89 (0.96,2.81)
Male	3.78 (2.35,5.21)

Incidence stratified by sex

Female	1.88 (1.52,2.24)
Male	3.22 (2.71,3.73)

Incidence stratified by age

Ages 40-44	0.3 (-0.04,0.64)
Ages 45-49	0.67 (0.23,1.1)
Ages 50-54	0.82 (0.38,1.27)
Ages 55-59	1.61 (1.04,2.18)
Ages 60-64	2.8 (2.16,3.45)
Ages 65-69	6.58 (5.45,7.71)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	5 (3,7)	10 (7,12)	25 (22,28)
CALIBER	8 (7,8)	17 (16,18)	47 (45,49)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	3(0,10)	10(5,18)	19(13,26)
Low	3(0,10)	7(3,14)	17(12,24)
Medium	1(0,8)	7(3,13)	23(17,32)
High	6(2,13)	7(3,14)	21(15,29)
Most deprived	8(3,16)	16(10,24)	48(37,60)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	4(2,7)	10(8,14)	25(21,29)
Scotland	6(1,19)	6(2,14)	23(15,35)
Wales	4(0,21)	9(2,22)	27(17,43)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=152960, Events=163

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.3 (0.88, 1.92)	0.185
BMI	obese	1.75 (1.16, 2.63)	0.00738
BMI	underweight	0 (0, Inf)	0.991
smoking	previous	1.02 (0.7, 1.49)	0.904
smoking	current	3.45 (2.37, 5.02)	8.66e-11
hypertension	yes	1.36 (0.94, 1.95)	0.101

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	F05	Delirium, not induced by alcohol and other psychoactive substances
41204	Diagnoses - secondary ICD10	F05	Delirium, not induced by alcohol and other psychoactive substances
40001	Underlying (primary) cause of death: ICD10	F05	Delirium, not induced by alcohol and other psychoactive substances
40002	Contributory (secondary) causes of death: ICD10	F05	Delirium, not induced by alcohol and other psychoactive substances
42040	GP clinical event records	2233.00	O/E - delirious
42040	GP clinical event records	E001100	Presenile dementia with delirium
42040	GP clinical event records	E003.00	Senile dementia with delirium
42040	GP clinical event records	E004100	Arteriosclerotic dementia with delirium
42040	GP clinical event records	E030000	Acute confusional state, post traumatic
42040	GP clinical event records	E030100	Acute confusional state, of infective origin
42040	GP clinical event records	E030200	Acute confusional state, of endocrine origin
42040	GP clinical event records	E030300	Acute confusional state, of metabolic origin
42040	GP clinical event records	E030400	Acute confusional state, of cerebrovascular origin
42040	GP clinical event records	E030.00	Acute confusional state
42040	GP clinical event records	E030.11	Delirium - acute organic
42040	GP clinical event records	E031000	Subacute confusional state, post traumatic
42040	GP clinical event records	E031100	Subacute confusional state, of infective origin
42040	GP clinical event records	E031300	Subacute confusional state, of metabolic origin
42040	GP clinical event records	E031400	Subacute confusional state, of cerebrovascular origin
42040	GP clinical event records	E031.00	Subacute confusional state
42040	GP clinical event records	E031.11	Delirium - subacute organic
42040	GP clinical event records	E031z00	Subacute confusional state NOS
42040	GP clinical event records	Eu04000	[X]Delirium not superimposed on dementia, so described
42040	GP clinical event records	Eu04100	[X]Delirium superimposed on dementia
42040	GP clinical event records	Eu04.00	[X]Delirium, not induced by alcohol+other psychoactive subs
42040	GP clinical event records	Eu04.11	[X]Acute / subacute brain syndrome
42040	GP clinical event records	Eu04.12	[X]Acute / subacute confusional state, nonalcoholic
42040	GP clinical event records	Eu04.13	[X]Acute / subacute infective psychosis
42040	GP clinical event records	Eu04.14	[X]Acute / subacute organic reaction
42040	GP clinical event records	Eu04.15	[X]Acute / subacute psycho-organic reaction
42040	GP clinical event records	Eu04y00	[X]Other delirium
42040	GP clinical event records	Eu04z00	[X]Delirium, unspecified
42040	GP clinical event records	XE1Z7	[X]Delirium, not induced by alcohol and other psychoactive subs
42040	GP clinical event records	XE1Z7	[X]Delirium, not induced by alcohol and other psychoactive subs
42040	GP clinical event records	XE1Z8	[X]Other delirium