Dementia

Metadata

Name	Dementia (dementia)
Category	Psychiatric
Sex
Adult	Yes
UUID	43a6b12f-72ea-46f3-a025-3c82247cc707
Definition	A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.

Ontologies

Disease Ontology (DOID)	DOID_1307
GWAS Catalogue	EFO_0004718
MeSH	D003704
SNOMED-CT	52448006
FinnGen	F5_DEMENTIA

Key Summary Statistics

Cases from any source

Total	7046
Female (%)	3366 (48%)
Male (%)	3680 (52%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	50.81 (46.02,55.59)
Male	61.32 (55.59,67.04)

Incidence stratified by sex

Female	1.85 (1.5,2.21)
Male	2.6 (2.14,3.06)

Incidence stratified by age

Ages 40-44	0.0 (0.0,0.0)
Ages 45-49	0.15 (-0.06,0.35)
Ages 50-54	0.57 (0.2,0.94)
Ages 55-59	1.1 (0.63,1.56)
Ages 60-64	2.24 (1.66,2.82)
Ages 65-69	7.02 (5.85,8.2)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	7 (5,11)	25 (21,29)	99 (93,106)
CALIBER	6 (5,7)	27 (25,28)	130 (126,134)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	4(1,11)	18(11,27)	79(67,92)
Low	2(0,9)	14(8,22)	78(66,91)
Medium	4(1,12)	22(15,32)	97(84,113)
High	7(2,15)	22(15,32)	105(90,121)
Most deprived	16(9,25)	47(36,60)	148(130,169)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	8(5,12)	26(22,31)	94(87,101)
Scotland	2(0,13)	21(13,34)	131(110,154)
Wales	6(1,22)	17(8,32)	111(88,139)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=152960, Events=163

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.3 (0.88, 1.92)	0.185
BMI	obese	1.75 (1.16, 2.63)	0.00738
BMI	underweight	0 (0, Inf)	0.991
smoking	previous	1.02 (0.7, 1.49)	0.904
smoking	current	3.45 (2.37, 5.02)	8.66e-11
hypertension	yes	1.36 (0.94, 1.95)	0.101

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1263	dementia/alzheimers/cognitive impairment
41202	Diagnoses - main ICD10	F00	Dementia in Alzheimer’s disease
41202	Diagnoses - main ICD10	F01	Vascular dementia
41202	Diagnoses - main ICD10	F03	Unspecified dementia
41202	Diagnoses - main ICD10	F05.1	Delirium superimposed on dementia
41202	Diagnoses - main ICD10	G30	Alzheimer’s disease
41204	Diagnoses - secondary ICD10	F00	Dementia in Alzheimer’s disease
41204	Diagnoses - secondary ICD10	F01	Vascular dementia
41204	Diagnoses - secondary ICD10	F03	Unspecified dementia
41204	Diagnoses - secondary ICD10	F05.1	Delirium superimposed on dementia
41204	Diagnoses - secondary ICD10	G30	Alzheimer’s disease
40001	Underlying (primary) cause of death: ICD10	F00	Dementia in Alzheimer’s disease
40001	Underlying (primary) cause of death: ICD10	F01	Vascular dementia
40001	Underlying (primary) cause of death: ICD10	F03	Unspecified dementia
40001	Underlying (primary) cause of death: ICD10	F05.1	Delirium superimposed on dementia
40001	Underlying (primary) cause of death: ICD10	G30	Alzheimer’s disease
40002	Contributory (secondary) causes of death: ICD10	F00	Dementia in Alzheimer’s disease
40002	Contributory (secondary) causes of death: ICD10	F01	Vascular dementia
40002	Contributory (secondary) causes of death: ICD10	F03	Unspecified dementia
40002	Contributory (secondary) causes of death: ICD10	F05.1	Delirium superimposed on dementia
40002	Contributory (secondary) causes of death: ICD10	G30	Alzheimer’s disease
42040	GP clinical event records	1461.00	H/O: dementia
42040	GP clinical event records	66h..00	Dementia monitoring
42040	GP clinical event records	6AB..00	Dementia annual review
42040	GP clinical event records	8CMZ.00	Dementia care plan
42040	GP clinical event records	9hD0.00	Excepted from dementia quality indicators: Patient unsuitabl
42040	GP clinical event records	9hD1.00	Excepted from dementia quality indicators: Informed dissent
42040	GP clinical event records	9hD..00	Exception reporting: dementia quality indicators
42040	GP clinical event records	9Ou1.00	Dementia monitoring first letter
42040	GP clinical event records	9Ou2.00	Dementia monitoring second letter
42040	GP clinical event records	9Ou3.00	Dementia monitoring third letter
42040	GP clinical event records	9Ou4.00	Dementia monitoring verbal invite
42040	GP clinical event records	9Ou5.00	Dementia monitoring telephone invite
42040	GP clinical event records	9Ou..00	Dementia monitoring administration
42040	GP clinical event records	E000.00	Uncomplicated senile dementia
42040	GP clinical event records	E001000	Uncomplicated presenile dementia
42040	GP clinical event records	E001100	Presenile dementia with delirium
42040	GP clinical event records	E001200	Presenile dementia with paranoia
42040	GP clinical event records	E001300	Presenile dementia with depression
42040	GP clinical event records	E001.00	Presenile dementia
42040	GP clinical event records	E001z00	Presenile dementia NOS
42040	GP clinical event records	E002000	Senile dementia with paranoia
42040	GP clinical event records	E002100	Senile dementia with depression
42040	GP clinical event records	E002.00	Senile dementia with depressive or paranoid features
42040	GP clinical event records	E002z00	Senile dementia with depressive or paranoid features NOS
42040	GP clinical event records	E003.00	Senile dementia with delirium
42040	GP clinical event records	E004000	Uncomplicated arteriosclerotic dementia
42040	GP clinical event records	E004100	Arteriosclerotic dementia with delirium
42040	GP clinical event records	E004200	Arteriosclerotic dementia with paranoia
42040	GP clinical event records	E004300	Arteriosclerotic dementia with depression
42040	GP clinical event records	E004.00	Arteriosclerotic dementia
42040	GP clinical event records	E004.11	Multi infarct dementia
42040	GP clinical event records	E004z00	Arteriosclerotic dementia NOS
42040	GP clinical event records	E00..00	Senile and presenile organic psychotic conditions
42040	GP clinical event records	E00..11	Senile dementia
42040	GP clinical event records	E00..12	Senile/presenile dementia
42040	GP clinical event records	E00y.00	Other senile and presenile organic psychoses
42040	GP clinical event records	E00y.11	Presbyophrenic psychosis
42040	GP clinical event records	E00z.00	Senile or presenile psychoses NOS
42040	GP clinical event records	E041.00	Dementia in conditions EC
42040	GP clinical event records	Eu00000	[X]Dementia in Alzheimer’s disease with early onset
42040	GP clinical event records	Eu00011	[X]Presenile dementia,Alzheimer’s type
42040	GP clinical event records	Eu00012	[X]Primary degen dementia, Alzheimer’s type, presenile onset
42040	GP clinical event records	Eu00013	[X]Alzheimer’s disease type 2
42040	GP clinical event records	Eu00100	[X]Dementia in Alzheimer’s disease with late onset
42040	GP clinical event records	Eu00111	[X]Alzheimer’s disease type 1
42040	GP clinical event records	Eu00112	[X]Senile dementia,Alzheimer’s type
42040	GP clinical event records	Eu00113	[X]Primary degen dementia of Alzheimer’s type, senile onset
42040	GP clinical event records	Eu00200	[X]Dementia in Alzheimer’s dis, atypical or mixed type
42040	GP clinical event records	Eu00.00	[X]Dementia in Alzheimer’s disease
42040	GP clinical event records	Eu00z00	[X]Dementia in Alzheimer’s disease, unspecified
42040	GP clinical event records	Eu00z11	[X]Alzheimer’s dementia unspec
42040	GP clinical event records	Eu01000	[X]Vascular dementia of acute onset
42040	GP clinical event records	Eu01100	[X]Multi-infarct dementia
42040	GP clinical event records	Eu01111	[X]Predominantly cortical dementia
42040	GP clinical event records	Eu01200	[X]Subcortical vascular dementia
42040	GP clinical event records	Eu01300	[X]Mixed cortical and subcortical vascular dementia
42040	GP clinical event records	Eu01.00	[X]Vascular dementia
42040	GP clinical event records	Eu01.11	[X]Arteriosclerotic dementia
42040	GP clinical event records	Eu01y00	[X]Other vascular dementia
42040	GP clinical event records	Eu01z00	[X]Vascular dementia, unspecified
42040	GP clinical event records	Eu02z00	[X] Unspecified dementia
42040	GP clinical event records	Eu02z11	[X] Presenile dementia NOS
42040	GP clinical event records	Eu02z12	[X] Presenile psychosis NOS
42040	GP clinical event records	Eu02z13	[X] Primary degenerative dementia NOS
42040	GP clinical event records	Eu02z14	[X] Senile dementia NOS
42040	GP clinical event records	Eu02z15	[X] Senile psychosis NOS
42040	GP clinical event records	Eu02z16	[X] Senile dementia, depressed or paranoid type
42040	GP clinical event records	Eu04100	[X]Delirium superimposed on dementia
42040	GP clinical event records	F110000	Alzheimer’s disease with early onset
42040	GP clinical event records	F110100	Alzheimer’s disease with late onset
42040	GP clinical event records	F110.00	Alzheimer’s disease
42040	GP clinical event records	Fyu3000	[X]Other Alzheimer’s disease
42040	GP clinical event records	ZS7C500	Language disorder of dementia
42040	GP clinical event records	XaMG0	Dementia monitoring first letter
42040	GP clinical event records	XaIKB	Alzheimer’s disease with early onset
42040	GP clinical event records	XaLFp	Excepted from dementia quality indicators: Informed dissent
42040	GP clinical event records	XaIKC	Alzheimer’s disease with late onset
42040	GP clinical event records	XE1Xt	Other senile and presenile organic psychoses
42040	GP clinical event records	XaMGF	Dementia annual review
42040	GP clinical event records	XaMGJ	Dementia monitoring verbal invite
42040	GP clinical event records	XE1Xr	Senile and presenile organic psychotic conditions
42040	GP clinical event records	XaMFy	Dementia monitoring administration
42040	GP clinical event records	XaMGG	Dementia monitoring second letter
42040	GP clinical event records	XaaBZ	Dementia care plan
42040	GP clinical event records	XaMJC	Dementia monitoring
42040	GP clinical event records	XaLFf	Exception reporting: dementia quality indicators
42040	GP clinical event records	XaMGK	Dementia monitoring telephone invite
42040	GP clinical event records	XaLFo	Excepted from dementia quality indicators: Patient unsuitable
42040	GP clinical event records	XaMGI	Dementia monitoring third letter