Metadata

Name Dermatitis (atopc/contact/other/unspecified) (dermatitis)
Category Skin
Sex
Adult Yes
UUID 1048f788-6727-4a07-8a7c-71df6eb9d84b
Definition A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin.

Ontologies

Disease Ontology (DOID) DOID_2723
GWAS Catalogue MONDO_0002406
MeSH D003872
SNOMED-CT 703938007
FinnGen L12_DERMATITISNAS

Key Summary Statistics

Cases from any source

Total 60208
Female (%) 34115 (57%)
Male (%) 26093 (43%)

Year first recorded

dermatitis year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced dermatitis cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of dermatitis

Baseline prevalence stratified by sex

Female 1555.51 (1531.12,1579.9)
Male 1364.37 (1339.2,1389.55)

Incidence stratified by sex

Female 84.37 (81.73,87.01)
Male 80.87 (78.07,83.66)

Incidence stratified by age

Ages 40-44 67.98 (62.35,73.6)
Ages 45-49 72.46 (67.48,77.45)
Ages 50-54 75.64 (70.93,80.34)
Ages 55-59 82.29 (77.86,86.73)
Ages 60-64 89.26 (85.27,93.26)
Ages 65-69 94.9 (90.17,99.63)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB dermatitis prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 1737 (1697,1777) 1757 (1726,1790) 1903 (1874,1931)
CALIBER 2136 (2124,2148) 2290 (2276,2305) 2480 (2464,2496)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 1788(1692,1888) 1761(1690,1834) 1919(1858,1981)
Low 1712(1618,1811) 1779(1707,1853) 1908(1847,1970)
Medium 1829(1734,1927) 1779(1707,1852) 1925(1863,1989)
High 1698(1614,1785) 1732(1662,1804) 1903(1838,1969)
Most deprived 1684(1606,1764) 1740(1670,1812) 1849(1783,1917)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 1696(1652,1740) 1738(1702,1774) 1881(1849,1912)
Scotland 1403(1301,1511) 1284(1210,1360) 1319(1251,1390)
Wales 2768(2584,2962) 2751(2612,2896) 3049(2920,3182)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153595, Events=126

Factor Level Hazard Ratio P value
BMI overweight 0.75 (0.51, 1.1) 0.143
BMI obese 0.53 (0.31, 0.88) 0.014
BMI underweight 0 (0, Inf) 0.992
smoking previous 1.05 (0.71, 1.56) 0.804
smoking current 1.31 (0.76, 2.25) 0.339
hypertension yes 1.64 (1.09, 2.47) 0.0186

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1669 contact dermatitis
20002 Non-cancer illness code, self-reported 1452 eczema/dermatitis
41202 Diagnoses - main ICD10 L20 Atopic dermatitis
41202 Diagnoses - main ICD10 L23 Allergic contact dermatitis
41202 Diagnoses - main ICD10 L24 Irritant contact dermatitis
41202 Diagnoses - main ICD10 L25 Unspecified contact dermatitis
41202 Diagnoses - main ICD10 L27 Dermatitis due to substances taken internally
41202 Diagnoses - main ICD10 L26 Exfoliative dermatitis
41202 Diagnoses - main ICD10 L28 Lichen simplex chronicus and prurigo
41202 Diagnoses - main ICD10 L30.0 Nummular dermatitis
41202 Diagnoses - main ICD10 L30.1 Dyshidrosis [pompholyx]
41202 Diagnoses - main ICD10 L30.2 Cutaneous autosensitization
41202 Diagnoses - main ICD10 L30.5 Pityriasis alba
41202 Diagnoses - main ICD10 L30.8 Other specified dermatitis
41202 Diagnoses - main ICD10 L30.9 Dermatitis, unspecified
41204 Diagnoses - secondary ICD10 L20 Atopic dermatitis
41204 Diagnoses - secondary ICD10 L23 Allergic contact dermatitis
41204 Diagnoses - secondary ICD10 L24 Irritant contact dermatitis
41204 Diagnoses - secondary ICD10 L25 Unspecified contact dermatitis
41204 Diagnoses - secondary ICD10 L27 Dermatitis due to substances taken internally
41204 Diagnoses - secondary ICD10 L26 Exfoliative dermatitis
41204 Diagnoses - secondary ICD10 L28 Lichen simplex chronicus and prurigo
41204 Diagnoses - secondary ICD10 L30.0 Nummular dermatitis
41204 Diagnoses - secondary ICD10 L30.1 Dyshidrosis [pompholyx]
41204 Diagnoses - secondary ICD10 L30.2 Cutaneous autosensitization
41204 Diagnoses - secondary ICD10 L30.5 Pityriasis alba
41204 Diagnoses - secondary ICD10 L30.8 Other specified dermatitis
41204 Diagnoses - secondary ICD10 L30.9 Dermatitis, unspecified
40001 Underlying (primary) cause of death: ICD10 L20 Atopic dermatitis
40001 Underlying (primary) cause of death: ICD10 L23 Allergic contact dermatitis
40001 Underlying (primary) cause of death: ICD10 L24 Irritant contact dermatitis
40001 Underlying (primary) cause of death: ICD10 L25 Unspecified contact dermatitis
40001 Underlying (primary) cause of death: ICD10 L27 Dermatitis due to substances taken internally
40001 Underlying (primary) cause of death: ICD10 L26 Exfoliative dermatitis
40001 Underlying (primary) cause of death: ICD10 L28 Lichen simplex chronicus and prurigo
40001 Underlying (primary) cause of death: ICD10 L30.0 Nummular dermatitis
40001 Underlying (primary) cause of death: ICD10 L30.1 Dyshidrosis [pompholyx]
40001 Underlying (primary) cause of death: ICD10 L30.2 Cutaneous autosensitization
40001 Underlying (primary) cause of death: ICD10 L30.5 Pityriasis alba
40001 Underlying (primary) cause of death: ICD10 L30.8 Other specified dermatitis
40001 Underlying (primary) cause of death: ICD10 L30.9 Dermatitis, unspecified
40002 Contributory (secondary) causes of death: ICD10 L20 Atopic dermatitis
40002 Contributory (secondary) causes of death: ICD10 L23 Allergic contact dermatitis
40002 Contributory (secondary) causes of death: ICD10 L24 Irritant contact dermatitis
40002 Contributory (secondary) causes of death: ICD10 L25 Unspecified contact dermatitis
40002 Contributory (secondary) causes of death: ICD10 L27 Dermatitis due to substances taken internally
40002 Contributory (secondary) causes of death: ICD10 L26 Exfoliative dermatitis
40002 Contributory (secondary) causes of death: ICD10 L28 Lichen simplex chronicus and prurigo
40002 Contributory (secondary) causes of death: ICD10 L30.0 Nummular dermatitis
40002 Contributory (secondary) causes of death: ICD10 L30.1 Dyshidrosis [pompholyx]
40002 Contributory (secondary) causes of death: ICD10 L30.2 Cutaneous autosensitization
40002 Contributory (secondary) causes of death: ICD10 L30.5 Pityriasis alba
40002 Contributory (secondary) causes of death: ICD10 L30.8 Other specified dermatitis
40002 Contributory (secondary) causes of death: ICD10 L30.9 Dermatitis, unspecified
42040 GP clinical event records 14F1.00 H/O: eczema
42040 GP clinical event records 26C4.00 Nipple eczema
42040 GP clinical event records 3355.00 Skin:type 1 immediate reaction
42040 GP clinical event records C391211 Thrombocytopenic eczema with immunodeficiency
42040 GP clinical event records F4D3000 Eczematous eyelid dermatitis
42040 GP clinical event records F4D3100 Contact or allergic eyelid dermatitis
42040 GP clinical event records F4D3111 Allergic dermatitis - eyelid
42040 GP clinical event records F4D3112 Contact eczema - eyelids
42040 GP clinical event records F4D4.00 Infective eyelid dermatitis of types resulting in deformity
42040 GP clinical event records F4D5.00 Other eyelid infective dermatitis
42040 GP clinical event records F502400 Acute eczematoid otitis extern
42040 GP clinical event records F502411 Eczema of external ear
42040 GP clinical event records H330.00 Extrinsic (atopic) asthma
42040 GP clinical event records M07y.11 Pustular eczema
42040 GP clinical event records M07z.14 Infected dermatitis
42040 GP clinical event records M102.00 Infectious eczematoid dermatitis
42040 GP clinical event records M102.11 Pustular eczema
42040 GP clinical event records M104.00 Pityriasis simplex
42040 GP clinical event records M11..00 Atopic dermatitis and related conditions
42040 GP clinical event records M111.00 Atopic dermatitis/eczema
42040 GP clinical event records M1…11 Dermatitis/dermatoses
42040 GP clinical event records M112.00 Infantile eczema
42040 GP clinical event records M113.00 Flexural eczema
42040 GP clinical event records M114.00 Allergic (intrinsic) eczema
42040 GP clinical event records M115.00 Besnier’s prurigo
42040 GP clinical event records M116.00 Neurodermatitis - diffuse
42040 GP clinical event records M116.11 Brocq’s neurodermatitis
42040 GP clinical event records M117.00 Neurodermatitis - atopic
42040 GP clinical event records M119.00 Discoid eczema
42040 GP clinical event records M11A.00 Asteatotic eczema
42040 GP clinical event records M11z.00 Atopic dermatitis NOS
42040 GP clinical event records M120.00 Contact dermatitis due to detergents
42040 GP clinical event records M12..00 Contact dermatitis and other eczemas
42040 GP clinical event records M121.00 Contact dermatitis due to oils and greases
42040 GP clinical event records M12..11 Contact dermatitis
42040 GP clinical event records M121.11 Grease contact dermatitis
42040 GP clinical event records M121.12 Oil contact dermatitis
42040 GP clinical event records M12..12 Contact eczema
42040 GP clinical event records M12..13 Occupational dermatitis
42040 GP clinical event records M122000 Contact dermatitis due to chlorocompound
42040 GP clinical event records M122.00 Contact dermatitis due to solvents
42040 GP clinical event records M122100 Contact dermatitis due to cyclohexane
42040 GP clinical event records M122300 Contact dermatitis due to glycol
42040 GP clinical event records M122z00 Contact dermatitis due to solvent NOS
42040 GP clinical event records M123000 Contact dermatitis due to arnica
42040 GP clinical event records M123.00 Contact dermatitis due to drugs and medicaments
42040 GP clinical event records M123100 Contact dermatitis due to fungicides
42040 GP clinical event records M123200 Contact dermatitis due to iodine
42040 GP clinical event records M123300 Contact dermatitis due to keratolytics
42040 GP clinical event records M123400 Contact dermatitis due to mercurials
42040 GP clinical event records M123500 Contact dermatitis due to neomycin
42040 GP clinical event records M123600 Contact dermatitis due to pediculocides
42040 GP clinical event records M123700 Contact dermatitis due to phenols
42040 GP clinical event records M123800 Contact dermatitis due to scabicides
42040 GP clinical event records M123z00 Contact dermatitis due to medicament NOS
42040 GP clinical event records M124000 Contact dermatitis due to acids
42040 GP clinical event records M124.00 Contact dermatitis due to other chemical products
42040 GP clinical event records M124100 Contact dermatitis due to adhesive plaster
42040 GP clinical event records M124111 Elastoplast contact dermatitis
42040 GP clinical event records M124200 Contact dermatitis due to alkalis
42040 GP clinical event records M124300 Contact dermatitis due to caustics
42040 GP clinical event records M124400 Contact dermatitis due to dichromate
42040 GP clinical event records M124500 Contact dermatitis due to insecticide
42040 GP clinical event records M124600 Contact dermatitis due to nylon
42040 GP clinical event records M124700 Contact dermatitis due to plastic
42040 GP clinical event records M124800 Contact dermatitis due to rubber
42040 GP clinical event records M124z00 Contact dermatitis: other chemicals NOS
42040 GP clinical event records M125000 Contact dermatitis due to cereals
42040 GP clinical event records M125.00 Contact dermatitis due to food in contact with skin
42040 GP clinical event records M125100 Contact dermatitis due to fish
42040 GP clinical event records M125200 Contact dermatitis due to flour
42040 GP clinical event records M125300 Contact dermatitis due to fruit
42040 GP clinical event records M125400 Contact dermatitis due to meat
42040 GP clinical event records M125500 Contact dermatitis due to milk
42040 GP clinical event records M125z00 Contact dermatitis due to food NOS
42040 GP clinical event records M125z11 Egg contact dermatitis
42040 GP clinical event records M126000 Contact dermatitis due to lacquer tree
42040 GP clinical event records M126.00 Contact dermatitis due to plants
42040 GP clinical event records M126100 Contact dermatitis due to poison-ivy
42040 GP clinical event records M126200 Contact dermatitis due to poison-oak
42040 GP clinical event records M126300 Contact dermatitis due to poison-sumac
42040 GP clinical event records M126500 Contact dermatitis due to primrose
42040 GP clinical event records M126600 Contact dermatitis due to ragweed
42040 GP clinical event records M126z00 Contact dermatitis due to plants NOS
42040 GP clinical event records M128000 Allergic contact dermatitis due to adhesives
42040 GP clinical event records M128.00 Allergic contact dermatitis
42040 GP clinical event records M128100 Allergic contact dermatitis due to cosmetics
42040 GP clinical event records M128200 Allergic contact dermatitis due drugs in contact with skin
42040 GP clinical event records M128300 Allergic contact dermatitis due to dyes
42040 GP clinical event records M128400 Allergic contact dermatitis due to other chemical products
42040 GP clinical event records M128500 Allergic contact dermatitis due to food in contact with skin
42040 GP clinical event records M128600 Allergic contact dermatitis due to plants, except food
42040 GP clinical event records M129000 Irritant contact dermatitis due to cosmetics
42040 GP clinical event records M129.00 Irritant contact dermatitis
42040 GP clinical event records M129100 Irritant contact dermatitis due drugs in contact with skin
42040 GP clinical event records M129200 Irritant contact dermatitis due to other chemical products
42040 GP clinical event records M129300 Irritant contact dermatitis due to food in contact with skin
42040 GP clinical event records M129400 Irritant contact dermatitis due to plants, except food
42040 GP clinical event records M12y000 Contact dermatitis due to cosmetics
42040 GP clinical event records M12y.00 Contact dermatitis due to other specified agents
42040 GP clinical event records M12y011 Lanolin contact dermatitis
42040 GP clinical event records M12y012 Perfume contact dermatitis
42040 GP clinical event records M12y100 Contact dermatitis due to cold weather
42040 GP clinical event records M12y200 Contact dermatitis due to dyes
42040 GP clinical event records M12y300 Contact dermatitis due to furs
42040 GP clinical event records M12y400 Contact dermatitis due to hot weather
42040 GP clinical event records M12y500 Contact dermatitis due to infra-red rays
42040 GP clinical event records M12y600 Contact dermatitis due to jewellery
42040 GP clinical event records M12y700 Contact dermatitis due to light (excluding sunlight)
42040 GP clinical event records M12y800 Contact dermatitis due to metals
42040 GP clinical event records M12y811 Nickel sensitivity
42040 GP clinical event records M12y900 Contact dermatitis due to preservatives
42040 GP clinical event records M12yA00 Contact dermatitis due to radiation NOS
42040 GP clinical event records M12yB00 Contact dermatitis due to ultra-violet rays (excluding sun)
42040 GP clinical event records M12yC00 Contact dermatitis due to x-rays
42040 GP clinical event records M12yD00 Contact dermatitis due to casting materials
42040 GP clinical event records M12yz00 Contact dermatitis: specified agent NOS
42040 GP clinical event records M12z000 Dermatitis NOS
42040 GP clinical event records M12z.00 Contact dermatitis NOS
42040 GP clinical event records M12z100 Eczema NOS
42040 GP clinical event records M12z111 Discoid eczema
42040 GP clinical event records M12z200 Infected eczema
42040 GP clinical event records M12z300 Hand eczema
42040 GP clinical event records M12z400 Erythrodermic eczema
42040 GP clinical event records M12zz00 Contact dermatitis NOS
42040 GP clinical event records M130000 Generalized skin eruption due to drugs and medicaments
42040 GP clinical event records M130.00 Ingestion dermatitis due to drugs
42040 GP clinical event records M13..00 Ingestion dermatitis
42040 GP clinical event records M130100 Localized skin eruption due to drugs and medicaments
42040 GP clinical event records M130.11 Drug induced rash
42040 GP clinical event records M130200 Drug-induced erythroderma
42040 GP clinical event records M131.00 Ingestion dermatitis due to food
42040 GP clinical event records M13y.00 Ingestion dermatitis due to other specified substance
42040 GP clinical event records M13z.00 Ingestion dermatitis NOS
42040 GP clinical event records M15y200 Pityriasis rubra (Hebra)
42040 GP clinical event records M165000 Pityriasis alba
42040 GP clinical event records M173.00 Lichen simplex
42040 GP clinical event records M182000 Prurigo aestivalis
42040 GP clinical event records M182.00 Prurigo
42040 GP clinical event records M182200 Prurigo mitis
42040 GP clinical event records M182300 Prurigo simplex
42040 GP clinical event records M182z00 Prurigo NOS
42040 GP clinical event records M183000 Prurigo nodularis (Hyde’s disease)
42040 GP clinical event records M183.00 Lichenification and lichen simplex chronicus
42040 GP clinical event records M183100 Neurodermatitis circumscripta
42040 GP clinical event records M183200 Lichen simplex
42040 GP clinical event records M183z00 Lichenification NOS
42040 GP clinical event records M1B..11 Juvenile plantar dermatitis
42040 GP clinical event records M1y0.00 Nummular dermatitis
42040 GP clinical event records M1y1.00 Cutaneous autosensitization
42040 GP clinical event records M252000 Dyshidrosis unspecified
42040 GP clinical event records M252.00 Dyshidrosis
42040 GP clinical event records M252100 Pompholyx unspecified
42040 GP clinical event records M252200 Cheiropompholyx
42040 GP clinical event records M252300 Podopompholyx
42040 GP clinical event records M252z00 Dyshidrosis NOS
42040 GP clinical event records M2y4100 Menstrual dermatosis
42040 GP clinical event records M2y4811 Juvenile plantar dermatitis
42040 GP clinical event records Myu2.00 [X]Dermatitis and eczema
42040 GP clinical event records Myu2100 [X]Allergic contact dermatitis due to oth chemical products
42040 GP clinical event records Myu2200 [X]Exacerbation of eczema
42040 GP clinical event records Myu2300 [X]Allergic contact dermatitis due to other agents
42040 GP clinical event records Myu2400 [X]Irritant contact dermatitis due to oth chemical products
42040 GP clinical event records Myu2500 [X]Irritant contact dermatitis due to other agents
42040 GP clinical event records Myu2600 [X]Unspcfd contact dermatitis due to other chemical products
42040 GP clinical event records Myu2700 [X]Unspecified contact dermatitis due to other agents
42040 GP clinical event records Myu2A00 [X]Other prurigo
42040 GP clinical event records Myu2C00 [X]Other specified dermatitis
42040 GP clinical event records M1831 Lichen simplex
42040 GP clinical event records XE17A Acute eczematoid otitis extern
42040 GP clinical event records X40Fx Nipple eczema
42040 GP clinical event records X506Q Asteatotic eczema
42040 GP clinical event records X505j Discoid eczema
42040 GP clinical event records XE1Av Eczema NOS
42040 GP clinical event records X5063 Irritant contact dermatitis
42040 GP clinical event records X505L Hand eczema
42040 GP clinical event records XE1Aw Ingestion dermatitis due to drugs
42040 GP clinical event records XE16i Contact or allergic eyelid dermatitis
42040 GP clinical event records XE16i Contact or allergic eyelid dermatitis
42040 GP clinical event records XE1At Contact dermatitis due to cosmetics
42040 GP clinical event records X505x Allergic contact dermatitis
42040 GP clinical event records XE1Aj Local infection skin/subcut tissue NOS
42040 GP clinical event records XE1Am Other skin and subcutaneous tissue inflammatory conditions
42040 GP clinical event records XE1Aq Contact dermatitis due to oils and greases
42040 GP clinical event records X506I Juvenile plantar dermatosis
42040 GP clinical event records XE1Au Contact dermatitis due to metals
42040 GP clinical event records X506I Juvenile plantar dermatosis
42040 GP clinical event records X506I Juvenile plantar dermatosis
42040 GP clinical event records M1831 Lichen simplex
42040 GP clinical event records M12z. Contact dermatitis NOS
42040 GP clinical event records X50Gm Drug-induced erythroderma
42040 GP clinical event records XE1As Contact dermatitis due to food NOS
42040 GP clinical event records XE1Ap Contact dermatitis and other eczemas
42040 GP clinical event records XE1Ag Other specified local infection of skin or subcutaneous tissue
42040 GP clinical event records XaY4o Infected eczema
42040 GP clinical event records XE1Ar Contact dermatitis due to adhesive plaster